The effect of Saccharin on spermatogenes, testiscular tissue and pituitary –gonad hormones axis in rats
Saccharin is an artificial, non-caloric sweetener used to sweeten products such as beverages, confectionary, biscuits, medicines and tooth pastes. This is while our body is not able to metabolized it. In the present study, the effect of saccharin on spermatogenesis, testicular tissue structure and p...
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| Format: | Article |
| Language: | fas |
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Jahrom University of Medical Sciences
2018-12-01
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| Series: | فصلنامه دانشگاه علوم پزشکی جهرم |
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| Online Access: | http://jmj.jums.ac.ir/article-1-1199-en.html |
| _version_ | 1819022809339265024 |
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| author | Reza Paknejad Vahid Hemayatkhah Jahromi |
| author_facet | Reza Paknejad Vahid Hemayatkhah Jahromi |
| author_sort | Reza Paknejad |
| collection | DOAJ |
| description | Saccharin is an artificial, non-caloric sweetener used to sweeten products such as beverages, confectionary, biscuits, medicines and tooth pastes. This is while our body is not able to metabolized it. In the present study, the effect of saccharin on spermatogenesis, testicular tissue structure and pituitary-gonadal hormone axis in rats was investigated.
Material and Methods: 35 adult male Wistar rats were divided into five equal groups. The control group did not receive any solvent or drug. The sham group received 1ml distilled water per day as an intraperitoneal injection. Experimental 1,2 and 3 groups received times daily, respectively 250,500 and 1000 mg/kg body weight saccharin intraperitoneal for 35 days. After about35 days, blood was taken from the animals and testicular tissue was isolated to examine the tissue. Data were analyzed by SPSS version 16 and one wayANOVA and post hoc Duncan test.
Results:The level of glucose in the experimental groups was significantly higher than the control group(p≤0.05).The concentration of testosterone DHEA, LH and FSH hormone in the experimental groups had significant decrease than control group.
Also the numbers of spermatogonia, primary and secondary spermatocyte, Spermatid, Spermatozoide and sperm in the experimental groups had significant decrease than control and sham groups. But Sertoli and Leydig cells indicated no significant difference(p≤0.05).
Conclusions:Saccharin can affect the amounts of hormones and sex cells male devastating effects have and these influences will perhaps amount to less to human generalized. Of course, in this case, how and the amount of the artificial sweetener used is very important |
| first_indexed | 2024-12-21T04:28:54Z |
| format | Article |
| id | doaj.art-63c38ec127854814ae9848ef21c69c71 |
| institution | Directory Open Access Journal |
| issn | 2008-7993 2008-8442 |
| language | fas |
| last_indexed | 2024-12-21T04:28:54Z |
| publishDate | 2018-12-01 |
| publisher | Jahrom University of Medical Sciences |
| record_format | Article |
| series | فصلنامه دانشگاه علوم پزشکی جهرم |
| spelling | doaj.art-63c38ec127854814ae9848ef21c69c712022-12-21T19:16:00ZfasJahrom University of Medical Sciencesفصلنامه دانشگاه علوم پزشکی جهرم2008-79932008-84422018-12-011641929The effect of Saccharin on spermatogenes, testiscular tissue and pituitary –gonad hormones axis in ratsReza Paknejad0Vahid Hemayatkhah Jahromi1 Saccharin is an artificial, non-caloric sweetener used to sweeten products such as beverages, confectionary, biscuits, medicines and tooth pastes. This is while our body is not able to metabolized it. In the present study, the effect of saccharin on spermatogenesis, testicular tissue structure and pituitary-gonadal hormone axis in rats was investigated. Material and Methods: 35 adult male Wistar rats were divided into five equal groups. The control group did not receive any solvent or drug. The sham group received 1ml distilled water per day as an intraperitoneal injection. Experimental 1,2 and 3 groups received times daily, respectively 250,500 and 1000 mg/kg body weight saccharin intraperitoneal for 35 days. After about35 days, blood was taken from the animals and testicular tissue was isolated to examine the tissue. Data were analyzed by SPSS version 16 and one wayANOVA and post hoc Duncan test. Results:The level of glucose in the experimental groups was significantly higher than the control group(p≤0.05).The concentration of testosterone DHEA, LH and FSH hormone in the experimental groups had significant decrease than control group. Also the numbers of spermatogonia, primary and secondary spermatocyte, Spermatid, Spermatozoide and sperm in the experimental groups had significant decrease than control and sham groups. But Sertoli and Leydig cells indicated no significant difference(p≤0.05). Conclusions:Saccharin can affect the amounts of hormones and sex cells male devastating effects have and these influences will perhaps amount to less to human generalized. Of course, in this case, how and the amount of the artificial sweetener used is very importanthttp://jmj.jums.ac.ir/article-1-1199-en.htmlsaccharintestispituitary – gonad hormones axisrat |
| spellingShingle | Reza Paknejad Vahid Hemayatkhah Jahromi The effect of Saccharin on spermatogenes, testiscular tissue and pituitary –gonad hormones axis in rats فصلنامه دانشگاه علوم پزشکی جهرم saccharin testis pituitary – gonad hormones axis rat |
| title | The effect of Saccharin on spermatogenes, testiscular tissue and pituitary –gonad hormones axis in rats |
| title_full | The effect of Saccharin on spermatogenes, testiscular tissue and pituitary –gonad hormones axis in rats |
| title_fullStr | The effect of Saccharin on spermatogenes, testiscular tissue and pituitary –gonad hormones axis in rats |
| title_full_unstemmed | The effect of Saccharin on spermatogenes, testiscular tissue and pituitary –gonad hormones axis in rats |
| title_short | The effect of Saccharin on spermatogenes, testiscular tissue and pituitary –gonad hormones axis in rats |
| title_sort | effect of saccharin on spermatogenes testiscular tissue and pituitary gonad hormones axis in rats |
| topic | saccharin testis pituitary – gonad hormones axis rat |
| url | http://jmj.jums.ac.ir/article-1-1199-en.html |
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