Enhancing an Oxidative “Trojan Horse” Action of Vitamin C with Arsenic Trioxide for Effective Suppression of KRAS-Mutant Cancers: A Promising Path at the Bedside

Enhancing an Oxidative “Trojan Horse” Action of Vitamin C with Arsenic Trioxide for Effective Suppression of KRAS-Mutant Cancers: A Promising Path at the Bedside

The turn-on mutations of the <i>KRAS</i> gene, coding a small GTPase coupling growth factor signaling, are contributing to nearly 25% of all human cancers, leading to highly malignant tumors with poor outcomes. Targeting of oncogenic KRAS remains a most challenging task in oncology. Rece...

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Bibliographic Details
Main Authors: Agata N. Burska, Bayansulu Ilyassova, Aruzhan Dildabek, Medina Khamijan, Dinara Begimbetova, Ferdinand Molnár, Dos D. Sarbassov
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
Kirsten rat sarcoma (KRAS) mutant ancers
Warburg effect
oxidative stress
arsenic trioxide (ATO)
vitamin C (VC also known as ascorbic acid)
reactive oxygen species (ROS)
Online Access:https://www.mdpi.com/2073-4409/11/21/3454

Internet

https://www.mdpi.com/2073-4409/11/21/3454

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