Plumbagin Alleviates Intracerebroventricular-Quinolinic Acid Induced Depression-like Behavior and Memory Deficits in Wistar Rats
Plumbagin, a hydroxy-1,4-naphthoquinone, confers neuroprotection via antioxidant and anti-inflammatory properties. The present study aimed to assess the effect of plumbagin on behavioral and memory deficits induced by intrahippocampal administration of Quinolinic acid (QA) in male Wistar rats and re...
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MDPI AG
2022-03-01
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| author | Mandeep Kumar Arora Anish Ratra Syed Mohammed Basheeruddin Asdaq Ali A. Alshamrani Abdulkhaliq J. Alsalman Mehnaz Kamal Ritu Tomar Jagannath Sahoo Jangra Ashok Mohd Imran |
| author_facet | Mandeep Kumar Arora Anish Ratra Syed Mohammed Basheeruddin Asdaq Ali A. Alshamrani Abdulkhaliq J. Alsalman Mehnaz Kamal Ritu Tomar Jagannath Sahoo Jangra Ashok Mohd Imran |
| author_sort | Mandeep Kumar Arora |
| collection | DOAJ |
| description | Plumbagin, a hydroxy-1,4-naphthoquinone, confers neuroprotection via antioxidant and anti-inflammatory properties. The present study aimed to assess the effect of plumbagin on behavioral and memory deficits induced by intrahippocampal administration of Quinolinic acid (QA) in male Wistar rats and reveal the associated mechanisms. QA (300 nM/4 μL in Normal saline) was administered i.c.v. in the hippocampus. QA administration caused depression-like behavior (forced swim test and tail suspension tests), anxiety-like behavior (open field test and elevated plus maze), and elevated anhedonia behavior (sucrose preference test). Furthermore, oxidative–nitrosative stress (increased nitrite content and lipid peroxidation with reduction of GSH), inflammation (increased IL-1β), cholinergic dysfunction, and mitochondrial complex (I, II, and IV) dysfunction were observed in the hippocampus region of QA-treated rats as compared to normal controls. Plumbagin (10 and 20 mg/kg; p.o.) treatment for 21 days significantly ameliorated behavioral and memory deficits in QA-administered rats. Moreover, plumbagin treatment restored the GSH level and reduced the MDA and nitrite level in the hippocampus. Furthermore, QA-induced cholinergic dysfunction and mitochondrial impairment were found to be ameliorated by plumbagin treatment. In conclusion, our results suggested that plumbagin offers a neuroprotective potential that could serve as a promising pharmacological approach to mitigate neurobehavioral changes associated with neurodegeneration. |
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| publishDate | 2022-03-01 |
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| series | Molecules |
| spelling | doaj.art-63c4ca44b1b74f819eb2f46a0fdbaced2023-11-30T21:41:55ZengMDPI AGMolecules1420-30492022-03-01276183410.3390/molecules27061834Plumbagin Alleviates Intracerebroventricular-Quinolinic Acid Induced Depression-like Behavior and Memory Deficits in Wistar RatsMandeep Kumar Arora0Anish Ratra1Syed Mohammed Basheeruddin Asdaq2Ali A. Alshamrani3Abdulkhaliq J. Alsalman4Mehnaz Kamal5Ritu Tomar6Jagannath Sahoo7Jangra Ashok8Mohd Imran9Department of Pharmacology, KIET School of Pharmacy, Ghaziabad 201206, IndiaDepartment of Pharmacology, KIET School of Pharmacy, Ghaziabad 201206, IndiaDepartment of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Diriyah, Riyadh 13713, Saudi ArabiaDepartment of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Clinical Pharmacy, Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi ArabiaSchool of Pharmaceutical and Population Health Informatics, DIT University, Dehradun 248171, IndiaSchool of Pharmaceutical and Population Health Informatics, DIT University, Dehradun 248171, IndiaDepartment of Pharmacology, KIET School of Pharmacy, Ghaziabad 201206, IndiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi ArabiaPlumbagin, a hydroxy-1,4-naphthoquinone, confers neuroprotection via antioxidant and anti-inflammatory properties. The present study aimed to assess the effect of plumbagin on behavioral and memory deficits induced by intrahippocampal administration of Quinolinic acid (QA) in male Wistar rats and reveal the associated mechanisms. QA (300 nM/4 μL in Normal saline) was administered i.c.v. in the hippocampus. QA administration caused depression-like behavior (forced swim test and tail suspension tests), anxiety-like behavior (open field test and elevated plus maze), and elevated anhedonia behavior (sucrose preference test). Furthermore, oxidative–nitrosative stress (increased nitrite content and lipid peroxidation with reduction of GSH), inflammation (increased IL-1β), cholinergic dysfunction, and mitochondrial complex (I, II, and IV) dysfunction were observed in the hippocampus region of QA-treated rats as compared to normal controls. Plumbagin (10 and 20 mg/kg; p.o.) treatment for 21 days significantly ameliorated behavioral and memory deficits in QA-administered rats. Moreover, plumbagin treatment restored the GSH level and reduced the MDA and nitrite level in the hippocampus. Furthermore, QA-induced cholinergic dysfunction and mitochondrial impairment were found to be ameliorated by plumbagin treatment. In conclusion, our results suggested that plumbagin offers a neuroprotective potential that could serve as a promising pharmacological approach to mitigate neurobehavioral changes associated with neurodegeneration.https://www.mdpi.com/1420-3049/27/6/1834quinolinic acidhippocampusplumbaginoxidative–nitrosative stress |
| spellingShingle | Mandeep Kumar Arora Anish Ratra Syed Mohammed Basheeruddin Asdaq Ali A. Alshamrani Abdulkhaliq J. Alsalman Mehnaz Kamal Ritu Tomar Jagannath Sahoo Jangra Ashok Mohd Imran Plumbagin Alleviates Intracerebroventricular-Quinolinic Acid Induced Depression-like Behavior and Memory Deficits in Wistar Rats Molecules quinolinic acid hippocampus plumbagin oxidative–nitrosative stress |
| title | Plumbagin Alleviates Intracerebroventricular-Quinolinic Acid Induced Depression-like Behavior and Memory Deficits in Wistar Rats |
| title_full | Plumbagin Alleviates Intracerebroventricular-Quinolinic Acid Induced Depression-like Behavior and Memory Deficits in Wistar Rats |
| title_fullStr | Plumbagin Alleviates Intracerebroventricular-Quinolinic Acid Induced Depression-like Behavior and Memory Deficits in Wistar Rats |
| title_full_unstemmed | Plumbagin Alleviates Intracerebroventricular-Quinolinic Acid Induced Depression-like Behavior and Memory Deficits in Wistar Rats |
| title_short | Plumbagin Alleviates Intracerebroventricular-Quinolinic Acid Induced Depression-like Behavior and Memory Deficits in Wistar Rats |
| title_sort | plumbagin alleviates intracerebroventricular quinolinic acid induced depression like behavior and memory deficits in wistar rats |
| topic | quinolinic acid hippocampus plumbagin oxidative–nitrosative stress |
| url | https://www.mdpi.com/1420-3049/27/6/1834 |
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