The Study of Nutraceutical Effects of the Whey Zonar and of Lyophilized Concentrate Obtained from Zonar in C26 Colon Carcinoma Grafted Subcutaneously in Balb/C Mice
This paper investigates the nutraceutical properties of the whey Zonar and of lyophilized concentrate obtained from Zonar in C26 tumor bearing BALB/C mice. The experiment was conducted on 30 female mice, divided into 6 groups (n=5). Groups 4, 5 and 6 were injected subcutaneously with 1*106 C26 carci...
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| Format: | Article |
| Language: | English |
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AcademicPres
2022-11-01
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| Series: | Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Food Science and Technology |
| Online Access: | https://journals.usamvcluj.ro/index.php/fst/article/view/14382 |
| _version_ | 1797299890455314432 |
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| author | Alexandra DREANCA Orsolya SARPATAKI Andra POPESCU Alexandra Gabriela TOMA Marioara MOLDOVAN Doina PRODAN Andras NAGY Bogdan SEVASTRE Ioan MARCUS |
| author_facet | Alexandra DREANCA Orsolya SARPATAKI Andra POPESCU Alexandra Gabriela TOMA Marioara MOLDOVAN Doina PRODAN Andras NAGY Bogdan SEVASTRE Ioan MARCUS |
| author_sort | Alexandra DREANCA |
| collection | DOAJ |
| description | This paper investigates the nutraceutical properties of the whey Zonar and of lyophilized concentrate obtained from Zonar in C26 tumor bearing BALB/C mice. The experiment was conducted on 30 female mice, divided into 6 groups (n=5). Groups 4, 5 and 6 were injected subcutaneously with 1*106 C26 carcinoma cells. Groups 2,3, 5 and 6 received a diet based on Zonar products. The evolution of body mass and tumor volume was assessed weekly. At the end of the 21-day study, blood samples for hematological, biochemical and oxidative stress analysis were drawn and tumor tissue samples were collected for histopathological examination. After 21 days, a significant in vivo reduction of the tumor volume in groups 5 and 6 was recorded. The biochemical analysis showed Zonar's protective muscular effects, due to decreases of the creatine-kinase level in groups 5 and 6. Further investigations revealed an increased level of glutathione in all groups which received Zonar, eliciting its antioxidant potential. Histopathologically, increased necrotic areas highlighted the anti-tumoral effect of the synergism between Zonar and the lyophilized concentrate. The results of this experiment implies that whey Zonar & the lyophilized whey prevents tumor cachexia, as well as other cancer associated adverse effects. |
| first_indexed | 2024-03-07T22:58:14Z |
| format | Article |
| id | doaj.art-63c52eae05e049b59584e803795a429f |
| institution | Directory Open Access Journal |
| issn | 2344-2344 2344-5300 |
| language | English |
| last_indexed | 2024-03-07T22:58:14Z |
| publishDate | 2022-11-01 |
| publisher | AcademicPres |
| record_format | Article |
| series | Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Food Science and Technology |
| spelling | doaj.art-63c52eae05e049b59584e803795a429f2024-02-22T22:13:53ZengAcademicPresBulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Food Science and Technology2344-23442344-53002022-11-0179211110.15835/buasvmcn-fst:2022.000214382The Study of Nutraceutical Effects of the Whey Zonar and of Lyophilized Concentrate Obtained from Zonar in C26 Colon Carcinoma Grafted Subcutaneously in Balb/C MiceAlexandra DREANCA0Orsolya SARPATAKI1Andra POPESCU2Alexandra Gabriela TOMA3Marioara MOLDOVAN4Doina PRODAN5Andras NAGY6Bogdan SEVASTRE7Ioan MARCUS8University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Mănăștur St. no 3-5, 400372, Cluj-Napoca, ClujUniversity of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Mănăștur St. no 3-5, 400372, Cluj-Napoca, ClujUniversity of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Mănăștur St. no 3-5, 400372, Cluj-Napoca, ClujUniversity of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Mănăștur St. no 3-5, 400372, Cluj-Napoca, Cluj2Babes Bolyai University - Institute for Research in Chemistry “Raluca Ripan”, Cluj-Napoca2Babes Bolyai University - Institute for Research in Chemistry “Raluca Ripan”, Cluj-NapocaUniversity of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Mănăștur St. no 3-5, 400372, Cluj-Napoca, ClujUniversity of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Mănăștur St. no 3-5, 400372, Cluj-Napoca, ClujUniversity of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Mănăștur St. no 3-5, 400372, Cluj-Napoca, ClujThis paper investigates the nutraceutical properties of the whey Zonar and of lyophilized concentrate obtained from Zonar in C26 tumor bearing BALB/C mice. The experiment was conducted on 30 female mice, divided into 6 groups (n=5). Groups 4, 5 and 6 were injected subcutaneously with 1*106 C26 carcinoma cells. Groups 2,3, 5 and 6 received a diet based on Zonar products. The evolution of body mass and tumor volume was assessed weekly. At the end of the 21-day study, blood samples for hematological, biochemical and oxidative stress analysis were drawn and tumor tissue samples were collected for histopathological examination. After 21 days, a significant in vivo reduction of the tumor volume in groups 5 and 6 was recorded. The biochemical analysis showed Zonar's protective muscular effects, due to decreases of the creatine-kinase level in groups 5 and 6. Further investigations revealed an increased level of glutathione in all groups which received Zonar, eliciting its antioxidant potential. Histopathologically, increased necrotic areas highlighted the anti-tumoral effect of the synergism between Zonar and the lyophilized concentrate. The results of this experiment implies that whey Zonar & the lyophilized whey prevents tumor cachexia, as well as other cancer associated adverse effects.https://journals.usamvcluj.ro/index.php/fst/article/view/14382 |
| spellingShingle | Alexandra DREANCA Orsolya SARPATAKI Andra POPESCU Alexandra Gabriela TOMA Marioara MOLDOVAN Doina PRODAN Andras NAGY Bogdan SEVASTRE Ioan MARCUS The Study of Nutraceutical Effects of the Whey Zonar and of Lyophilized Concentrate Obtained from Zonar in C26 Colon Carcinoma Grafted Subcutaneously in Balb/C Mice Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Food Science and Technology |
| title | The Study of Nutraceutical Effects of the Whey Zonar and of Lyophilized Concentrate Obtained from Zonar in C26 Colon Carcinoma Grafted Subcutaneously in Balb/C Mice |
| title_full | The Study of Nutraceutical Effects of the Whey Zonar and of Lyophilized Concentrate Obtained from Zonar in C26 Colon Carcinoma Grafted Subcutaneously in Balb/C Mice |
| title_fullStr | The Study of Nutraceutical Effects of the Whey Zonar and of Lyophilized Concentrate Obtained from Zonar in C26 Colon Carcinoma Grafted Subcutaneously in Balb/C Mice |
| title_full_unstemmed | The Study of Nutraceutical Effects of the Whey Zonar and of Lyophilized Concentrate Obtained from Zonar in C26 Colon Carcinoma Grafted Subcutaneously in Balb/C Mice |
| title_short | The Study of Nutraceutical Effects of the Whey Zonar and of Lyophilized Concentrate Obtained from Zonar in C26 Colon Carcinoma Grafted Subcutaneously in Balb/C Mice |
| title_sort | study of nutraceutical effects of the whey zonar and of lyophilized concentrate obtained from zonar in c26 colon carcinoma grafted subcutaneously in balb c mice |
| url | https://journals.usamvcluj.ro/index.php/fst/article/view/14382 |
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