Functionalization of Nanoparticulate Drug Delivery Systems and Its Influence in Cancer Therapy
Research into the application of nanocarriers in the delivery of cancer-fighting drugs has been a promising research area for decades. On the other hand, their cytotoxic effects on cells, low uptake efficiency, and therapeutic resistance have limited their therapeutic use. However, the urgency of pr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/5/1113 |
| _version_ | 1797496508930588672 |
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| author | Theodora Amanda Seidu Perpetua Takunda Kutoka Dorothy Owusu Asante Muhammad Asim Farooq Raphael N. Alolga Wang Bo |
| author_facet | Theodora Amanda Seidu Perpetua Takunda Kutoka Dorothy Owusu Asante Muhammad Asim Farooq Raphael N. Alolga Wang Bo |
| author_sort | Theodora Amanda Seidu |
| collection | DOAJ |
| description | Research into the application of nanocarriers in the delivery of cancer-fighting drugs has been a promising research area for decades. On the other hand, their cytotoxic effects on cells, low uptake efficiency, and therapeutic resistance have limited their therapeutic use. However, the urgency of pressing healthcare needs has resulted in the functionalization of nanoparticles’ (NPs) physicochemical properties to improve clinical outcomes of new, old, and repurposed drugs. This article reviews recent research on methods for targeting functionalized nanoparticles to the tumor microenvironment (TME). Additionally, the use of relevant engineering techniques for surface functionalization of nanocarriers (liposomes, dendrimers, and mesoporous silica) and their critical roles in overcoming the current limitations in cancer therapy—targeting ligands used for targeted delivery, stimuli strategies, and multifunctional nanoparticles—were all reviewed. The limitations and future perspectives of functionalized nanoparticles were also finally discussed. Using relevant keywords, published scientific literature from all credible sources was retrieved. A quick search of the literature yielded almost 400 publications. The subject matter of this review was addressed adequately using an inclusion/exclusion criterion. The content of this review provides a reasonable basis for further studies to fully exploit the potential of these nanoparticles in cancer therapy. |
| first_indexed | 2024-03-10T03:05:38Z |
| format | Article |
| id | doaj.art-63c57c025e3040c596be2d666abb3af0 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T03:05:38Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-63c57c025e3040c596be2d666abb3af02023-11-23T12:39:50ZengMDPI AGPharmaceutics1999-49232022-05-01145111310.3390/pharmaceutics14051113Functionalization of Nanoparticulate Drug Delivery Systems and Its Influence in Cancer TherapyTheodora Amanda Seidu0Perpetua Takunda Kutoka1Dorothy Owusu Asante2Muhammad Asim Farooq3Raphael N. Alolga4Wang Bo5Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, ChinaDepartment of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, ChinaSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, ChinaDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, AustraliaState Key Laboratory of Natural Medicines, Department of Pharmacognosy, China Pharmaceutical University, No. 639 Longmian Road, Nanjing 211198, ChinaDepartment of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, ChinaResearch into the application of nanocarriers in the delivery of cancer-fighting drugs has been a promising research area for decades. On the other hand, their cytotoxic effects on cells, low uptake efficiency, and therapeutic resistance have limited their therapeutic use. However, the urgency of pressing healthcare needs has resulted in the functionalization of nanoparticles’ (NPs) physicochemical properties to improve clinical outcomes of new, old, and repurposed drugs. This article reviews recent research on methods for targeting functionalized nanoparticles to the tumor microenvironment (TME). Additionally, the use of relevant engineering techniques for surface functionalization of nanocarriers (liposomes, dendrimers, and mesoporous silica) and their critical roles in overcoming the current limitations in cancer therapy—targeting ligands used for targeted delivery, stimuli strategies, and multifunctional nanoparticles—were all reviewed. The limitations and future perspectives of functionalized nanoparticles were also finally discussed. Using relevant keywords, published scientific literature from all credible sources was retrieved. A quick search of the literature yielded almost 400 publications. The subject matter of this review was addressed adequately using an inclusion/exclusion criterion. The content of this review provides a reasonable basis for further studies to fully exploit the potential of these nanoparticles in cancer therapy.https://www.mdpi.com/1999-4923/14/5/1113surface functionalizationmultifunctional nanoparticles (MNPs)cancer therapyliposomesdendrimersmesoporous silica NPs |
| spellingShingle | Theodora Amanda Seidu Perpetua Takunda Kutoka Dorothy Owusu Asante Muhammad Asim Farooq Raphael N. Alolga Wang Bo Functionalization of Nanoparticulate Drug Delivery Systems and Its Influence in Cancer Therapy Pharmaceutics surface functionalization multifunctional nanoparticles (MNPs) cancer therapy liposomes dendrimers mesoporous silica NPs |
| title | Functionalization of Nanoparticulate Drug Delivery Systems and Its Influence in Cancer Therapy |
| title_full | Functionalization of Nanoparticulate Drug Delivery Systems and Its Influence in Cancer Therapy |
| title_fullStr | Functionalization of Nanoparticulate Drug Delivery Systems and Its Influence in Cancer Therapy |
| title_full_unstemmed | Functionalization of Nanoparticulate Drug Delivery Systems and Its Influence in Cancer Therapy |
| title_short | Functionalization of Nanoparticulate Drug Delivery Systems and Its Influence in Cancer Therapy |
| title_sort | functionalization of nanoparticulate drug delivery systems and its influence in cancer therapy |
| topic | surface functionalization multifunctional nanoparticles (MNPs) cancer therapy liposomes dendrimers mesoporous silica NPs |
| url | https://www.mdpi.com/1999-4923/14/5/1113 |
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