Normal reference values for aerobic fitness in cystic fibrosis: a scoping review
Objective The importance of aerobic fitness (VO2peak) in cystic fibrosis (CF) is well established, and regular exercise testing is recommended. To standardise VO2peak, a ‘percentage of predicted’ (%pred) derived from normative reference values (NRV), as promoted by the 2015 European Cystic Fibrosis...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-12-01
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| Series: | BMJ Open Sport & Exercise Medicine |
| Online Access: | https://bmjopensem.bmj.com/content/8/4/e001490.full |
| _version_ | 1797987344256598016 |
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| author | Curtis A Wadey Craig A Williams Owen W Tomlinson |
| author_facet | Curtis A Wadey Craig A Williams Owen W Tomlinson |
| author_sort | Curtis A Wadey |
| collection | DOAJ |
| description | Objective The importance of aerobic fitness (VO2peak) in cystic fibrosis (CF) is well established, and regular exercise testing is recommended. To standardise VO2peak, a ‘percentage of predicted’ (%pred) derived from normative reference values (NRV), as promoted by the 2015 European Cystic Fibrosis Society Exercise Working Group (ECFS EWG), can be reported. However, the NRVs used in CF and their relative frequency is unknown.Method A scoping review was performed via systematic database searches (PubMed, Embase, Web of Science, SciELO, EBSCO) and forward citation searches for studies that include people with CF and report VO2peak as %pred. Studies were screened using Covidence, and data related to patient demographics, testing modality and reference equations were extracted. Additional analyses were performed on studies published in 2016–2021, following the ECFS EWG statement in 2015.Results A total of 170 studies were identified, dating from 1984 to 2022, representing 6831 patients with CF, citing 34 NRV. Most studies (154/170) used cycle ergometry, 15/170 used treadmills, and the remainder used alternative, combination or undeclared modalities. In total, 61/170 failed to declare the NRV used. There were 61 studies published since the ECFS EWG statement, whereby 18/61 used the suggested NRV.Conclusion There is a wide discrepancy in NRV used in the CF literature base to describe VO2peak as %pred, with few studies using NRV from the ECFS EWG statement. This high variance compromises the interpretation and comparison of studies while leaving them susceptible to misinterpretation and limiting replication. Standardisation and alignment of reporting of VO2peak values are urgently needed. |
| first_indexed | 2024-04-11T07:46:08Z |
| format | Article |
| id | doaj.art-63c60014c2f74a22b7c497ea8534095e |
| institution | Directory Open Access Journal |
| issn | 2055-7647 |
| language | English |
| last_indexed | 2024-04-11T07:46:08Z |
| publishDate | 2022-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Sport & Exercise Medicine |
| spelling | doaj.art-63c60014c2f74a22b7c497ea8534095e2022-12-22T04:36:16ZengBMJ Publishing GroupBMJ Open Sport & Exercise Medicine2055-76472022-12-018410.1136/bmjsem-2022-001490Normal reference values for aerobic fitness in cystic fibrosis: a scoping reviewCurtis A Wadey0Craig A Williams1Owen W Tomlinson2Children`s Health and Exercise Research Centre (CHERC), University of Exeter, Exeter, UKChildren’s Health and Exercise Research Centre, University of Exeter, Exeter, UKChildren’s Health and Exercise Research Centre, Department of Public Health and Sport Sciences, Faculty of Health and Life Sceinces, University of Exeter, Exeter, UKObjective The importance of aerobic fitness (VO2peak) in cystic fibrosis (CF) is well established, and regular exercise testing is recommended. To standardise VO2peak, a ‘percentage of predicted’ (%pred) derived from normative reference values (NRV), as promoted by the 2015 European Cystic Fibrosis Society Exercise Working Group (ECFS EWG), can be reported. However, the NRVs used in CF and their relative frequency is unknown.Method A scoping review was performed via systematic database searches (PubMed, Embase, Web of Science, SciELO, EBSCO) and forward citation searches for studies that include people with CF and report VO2peak as %pred. Studies were screened using Covidence, and data related to patient demographics, testing modality and reference equations were extracted. Additional analyses were performed on studies published in 2016–2021, following the ECFS EWG statement in 2015.Results A total of 170 studies were identified, dating from 1984 to 2022, representing 6831 patients with CF, citing 34 NRV. Most studies (154/170) used cycle ergometry, 15/170 used treadmills, and the remainder used alternative, combination or undeclared modalities. In total, 61/170 failed to declare the NRV used. There were 61 studies published since the ECFS EWG statement, whereby 18/61 used the suggested NRV.Conclusion There is a wide discrepancy in NRV used in the CF literature base to describe VO2peak as %pred, with few studies using NRV from the ECFS EWG statement. This high variance compromises the interpretation and comparison of studies while leaving them susceptible to misinterpretation and limiting replication. Standardisation and alignment of reporting of VO2peak values are urgently needed.https://bmjopensem.bmj.com/content/8/4/e001490.full |
| spellingShingle | Curtis A Wadey Craig A Williams Owen W Tomlinson Normal reference values for aerobic fitness in cystic fibrosis: a scoping review BMJ Open Sport & Exercise Medicine |
| title | Normal reference values for aerobic fitness in cystic fibrosis: a scoping review |
| title_full | Normal reference values for aerobic fitness in cystic fibrosis: a scoping review |
| title_fullStr | Normal reference values for aerobic fitness in cystic fibrosis: a scoping review |
| title_full_unstemmed | Normal reference values for aerobic fitness in cystic fibrosis: a scoping review |
| title_short | Normal reference values for aerobic fitness in cystic fibrosis: a scoping review |
| title_sort | normal reference values for aerobic fitness in cystic fibrosis a scoping review |
| url | https://bmjopensem.bmj.com/content/8/4/e001490.full |
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