Myofibroblasts impair myocardial impulse propagation by heterocellular connexin43 gap-junctional coupling through micropores

Myofibroblasts impair myocardial impulse propagation by heterocellular connexin43 gap-junctional coupling through micropores

Aim: Composite population of myofibroblasts (MFs) within myocardial tissue is known to alter impulse propagation, leading to arrhythmias. However, it remains unclear whether and how MFs alter their propagation patterns when contacting cardiomyocytes (CMs) without complex structural insertions in the...

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Bibliographic Details
Main Authors: Yumika Tsuji, Takehiro Ogata, Kentaro Mochizuki, Shoko Tamura, Yuma Morishita, Tetsuro Takamatsu, Satoaki Matoba, Hideo Tanaka
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Physiology
Subjects:
myofibroblast
cardiomyocyte
optical mapping
impulse propagation
electrotonic effect
connexin 43
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2024.1352911/full

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