Clinicopathological Study of Spectrum of Muscle Disorders in a Tertiary Care Hospital
Introduction: The diagnostic approach to muscle disorders is often challenging due to paucity of literature, unavailability of ancillary facilities, affordability and improper sample collection. The role of pathologist in terms of categorising the muscle biopsy interpretation with limited resour...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2021-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/15765/52645_CE(Ra1)_F(SS)_PF1(AKA_SS)_PFA(AKA_KM)_PN(KM).pdf |
| Summary: | Introduction: The diagnostic approach to muscle disorders is
often challenging due to paucity of literature, unavailability of
ancillary facilities, affordability and improper sample collection.
The role of pathologist in terms of categorising the muscle
biopsy interpretation with limited resources plays an imminent
role in guiding clinicians for further therapeutic approach.
Aim: To analyse spectrum of various muscle disorders and to
relate their clinical and histopathological findings.
Materials and Methods: This was observational retrospective as
well as prospective study of 63 muscle biopsies received during
10 years period from June 2009 to June 2019, at Department
of Pathology in Grant Government Medical College, Mumbai,
India. Slides of muscle biopsies received prior to June 2017
were restained and reviewed while muscle biopsies after this
period were studied prospectively. Various histomorphological
and histopathological (fascicular architecture, variation in size
and shape of fibers, necrosis and degenerative/regenerative
changes, nuclear characteristics, type and distribution of
inflammatory cells along with interstitial changes) features were
studied in detail and the findings were compared with similar
previous studies. These findings when clubbed together with
clinical, biochemical and Electromyography (EMG) findings, to
guide the path towards appropriate diagnosis.
Results: The present study evaluated and analysed 63 muscle
biopsies, clinically, histopathologically and histomorphologically.
Mean age was 30.6 years, 43 (68.25%) patients were males
and 20 (31.75%) patients were females. A number of 12
(19.04%) patients were clinically diagnosed as having limbgirdle muscular dystrophy, followed by 9 (14.28%) patients as
inflammatory myositis. Eight patients (12.69%) were diagnosed
as Polymyositis (PM), five (7.93%) as Dermatomyositis (DM),
one (1.58%) patient each of juvenile DM and inclusion body
myositis. Histopathologically, the cases diagnosed were PM14 cases (22.22%) followed by muscular dystrophy (excluding
limb-girdle muscular dystrophy)- 12 cases (19.04%) and limbgirdle muscular dystrophy- 9 cases (14.28%).
Conclusion: Although molecular and genetic studies are need of
hour, histomorphological features helps in proper categorisation of
cases, however close liaison between pathologist and clinicians is
essential and histopathological findings should only be interpreted
in light of clinical manifestations and laboratory findings. |
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| ISSN: | 2249-782X 0973-709X |