Stem Cell Therapy for Corneal Regeneration Medicine and Contemporary Nanomedicine for Corneal Disorders
The ocular surface is the outermost part of the visual system that faces many extrinsic or intrinsic threats, such as chemical burn, infectious pathogens, thermal injury, Stevens–Johnson syndrome, ocular pemphegoid, and other autoimmune diseases. The cornea plays an important role in conducting ligh...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2015-10-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.3727/096368914X685744 |
| _version_ | 1818533119486066688 |
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| author | Chih-Chien Hsu Chi-Hsien Peng Kuo-Hsuan Hung Yi-Yen Lee Tai-Chi Lin Shih-Fan Jang Jorn-Hon Liu Yan-Ting Chen Lin-Chung Woung Chien-Ying Wang Ching-Yao Tsa Shih-Hwa Chiou Shih-Jen Chen Yuh-Lih Chang Ph.D. |
| author_facet | Chih-Chien Hsu Chi-Hsien Peng Kuo-Hsuan Hung Yi-Yen Lee Tai-Chi Lin Shih-Fan Jang Jorn-Hon Liu Yan-Ting Chen Lin-Chung Woung Chien-Ying Wang Ching-Yao Tsa Shih-Hwa Chiou Shih-Jen Chen Yuh-Lih Chang Ph.D. |
| author_sort | Chih-Chien Hsu |
| collection | DOAJ |
| description | The ocular surface is the outermost part of the visual system that faces many extrinsic or intrinsic threats, such as chemical burn, infectious pathogens, thermal injury, Stevens–Johnson syndrome, ocular pemphegoid, and other autoimmune diseases. The cornea plays an important role in conducting light into the eyes and protecting intraocular structures. Several ocular surface diseases will lead to the neovascularization or conjunctivalization of corneal epithelium, leaving opacified optical media. It is believed that some corneal limbal cells may present stem cell-like properties and are capable of regenerating corneal epithelium. Therefore, cultivation of limbal cells and reconstruction of the ocular surface with these limbal cell grafts have attracted tremendous interest in the past few years. Currently, stem cells are found to potentiate regenerative medicine by their capability of differentiation into multiple lineage cells. Among these, the most common cell sources for clinical use are embryonic, adult, and induced stem cells. Different stem cells have varied specific advantages and limitations for in vivo and in vitro expansion. Other than ocular surface diseases, culture and transplantation of corneal endothelial cells is another major issue for corneal decompensation and awaits further studies to find out comprehensive solutions dealing with nonregenerative corneal endothelium. Recently, studies of in vitro endothelium culture and ρ-associated kinase (ROCK) inhibitor have gained encouraging results. Some clinical trials have already been finished and achieved remarkable vision recovery. Finally, nanotechnology has shown great improvement in ocular drug delivery systems during the past two decades. Strategies to reconstruct the ocular surface could combine with nanoparticles to facilitate wound healing, drug delivery, and even neovascularization inhibition. In this review article, we summarized the major advances of corneal limbal stem cells, limbal stem cell deficiency, corneal endothelial cell culture/transplantation, and application of nanotechnology on ocular surface reconstruction. We also illustrated potential applications of current knowledge for the future treatment of ocular surface diseases. |
| first_indexed | 2024-12-11T17:54:28Z |
| format | Article |
| id | doaj.art-63cb328275de473d9641749ee8483768 |
| institution | Directory Open Access Journal |
| issn | 0963-6897 1555-3892 |
| language | English |
| last_indexed | 2024-12-11T17:54:28Z |
| publishDate | 2015-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-63cb328275de473d9641749ee84837682022-12-22T00:56:07ZengSAGE PublishingCell Transplantation0963-68971555-38922015-10-012410.3727/096368914X685744Stem Cell Therapy for Corneal Regeneration Medicine and Contemporary Nanomedicine for Corneal DisordersChih-Chien Hsu0Chi-Hsien Peng1Kuo-Hsuan Hung2Yi-Yen Lee3Tai-Chi Lin4Shih-Fan Jang5Jorn-Hon Liu6Yan-Ting Chen7Lin-Chung Woung8Chien-Ying Wang9Ching-Yao Tsa10Shih-Hwa Chiou11Shih-Jen Chen12Yuh-Lih Chang Ph.D.13Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, ROCDepartment of Ophthalmology, Shin Kong Wu Ho-Su Memorial Hospital and Fu-Jen Catholic University, Taipei, Taiwan, ROCSchool of Medicine, National Yang-Ming University, Taipei, Taiwan, ROCDepartment of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, ROCInstitute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, ROCInstitute of Pharmacology, National Yang-Ming University, Taipei, Taiwan, ROCDepartment of Ophthalmology, Cheng-Hsin Hospital, Taipei, Taiwan, ROCDepartment of Optometrics, Central Taiwan University of Science and Technology, Changhua, Taiwan, ROCDepartment of Ophthalmology, Taipei City Hospital, Taipei, Taiwan, ROCInstitute of Pharmacology, National Yang-Ming University, Taipei, Taiwan, ROCDepartment of Ophthalmology, Taipei City Hospital, Taipei, Taiwan, ROCInstitute of Pharmacology, National Yang-Ming University, Taipei, Taiwan, ROCSchool of Medicine, National Yang-Ming University, Taipei, Taiwan, ROCInstitute of Pharmacology, National Yang-Ming University, Taipei, Taiwan, ROCThe ocular surface is the outermost part of the visual system that faces many extrinsic or intrinsic threats, such as chemical burn, infectious pathogens, thermal injury, Stevens–Johnson syndrome, ocular pemphegoid, and other autoimmune diseases. The cornea plays an important role in conducting light into the eyes and protecting intraocular structures. Several ocular surface diseases will lead to the neovascularization or conjunctivalization of corneal epithelium, leaving opacified optical media. It is believed that some corneal limbal cells may present stem cell-like properties and are capable of regenerating corneal epithelium. Therefore, cultivation of limbal cells and reconstruction of the ocular surface with these limbal cell grafts have attracted tremendous interest in the past few years. Currently, stem cells are found to potentiate regenerative medicine by their capability of differentiation into multiple lineage cells. Among these, the most common cell sources for clinical use are embryonic, adult, and induced stem cells. Different stem cells have varied specific advantages and limitations for in vivo and in vitro expansion. Other than ocular surface diseases, culture and transplantation of corneal endothelial cells is another major issue for corneal decompensation and awaits further studies to find out comprehensive solutions dealing with nonregenerative corneal endothelium. Recently, studies of in vitro endothelium culture and ρ-associated kinase (ROCK) inhibitor have gained encouraging results. Some clinical trials have already been finished and achieved remarkable vision recovery. Finally, nanotechnology has shown great improvement in ocular drug delivery systems during the past two decades. Strategies to reconstruct the ocular surface could combine with nanoparticles to facilitate wound healing, drug delivery, and even neovascularization inhibition. In this review article, we summarized the major advances of corneal limbal stem cells, limbal stem cell deficiency, corneal endothelial cell culture/transplantation, and application of nanotechnology on ocular surface reconstruction. We also illustrated potential applications of current knowledge for the future treatment of ocular surface diseases.https://doi.org/10.3727/096368914X685744 |
| spellingShingle | Chih-Chien Hsu Chi-Hsien Peng Kuo-Hsuan Hung Yi-Yen Lee Tai-Chi Lin Shih-Fan Jang Jorn-Hon Liu Yan-Ting Chen Lin-Chung Woung Chien-Ying Wang Ching-Yao Tsa Shih-Hwa Chiou Shih-Jen Chen Yuh-Lih Chang Ph.D. Stem Cell Therapy for Corneal Regeneration Medicine and Contemporary Nanomedicine for Corneal Disorders Cell Transplantation |
| title | Stem Cell Therapy for Corneal Regeneration Medicine and Contemporary Nanomedicine for Corneal Disorders |
| title_full | Stem Cell Therapy for Corneal Regeneration Medicine and Contemporary Nanomedicine for Corneal Disorders |
| title_fullStr | Stem Cell Therapy for Corneal Regeneration Medicine and Contemporary Nanomedicine for Corneal Disorders |
| title_full_unstemmed | Stem Cell Therapy for Corneal Regeneration Medicine and Contemporary Nanomedicine for Corneal Disorders |
| title_short | Stem Cell Therapy for Corneal Regeneration Medicine and Contemporary Nanomedicine for Corneal Disorders |
| title_sort | stem cell therapy for corneal regeneration medicine and contemporary nanomedicine for corneal disorders |
| url | https://doi.org/10.3727/096368914X685744 |
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