Presepsin values and prognostic nutritional index predict mortality in intensive care unit patients with sepsis: a pilot study
Abstract Objective Sepsis is a major cause of mortality for critically ill patients. This study aimed to determine whether presepsin values can predict mortality in patients with sepsis. Results Receiver operating characteristic (ROC) curve analysis, Log-rank test, and multivariate analysis identifi...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-06-01
|
| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13104-021-05659-9 |
| _version_ | 1818656272965173248 |
|---|---|
| author | Yuichiro Shimoyama Osamu Umegaki Noriko Kadono Toshiaki Minami |
| author_facet | Yuichiro Shimoyama Osamu Umegaki Noriko Kadono Toshiaki Minami |
| author_sort | Yuichiro Shimoyama |
| collection | DOAJ |
| description | Abstract Objective Sepsis is a major cause of mortality for critically ill patients. This study aimed to determine whether presepsin values can predict mortality in patients with sepsis. Results Receiver operating characteristic (ROC) curve analysis, Log-rank test, and multivariate analysis identified presepsin values and Prognostic Nutritional Index as predictors of mortality in sepsis patients. Presepsin value on Day 1 was a predictor of early mortality, i.e., death within 7 days of ICU admission; ROC curve analysis revealed an AUC of 0.84, sensitivity of 89%, and specificity of 77%; and multivariate analysis showed an OR of 1.0007, with a 95%CI of 1.0001–1.0013 (p = 0.0320). |
| first_indexed | 2024-12-17T03:22:57Z |
| format | Article |
| id | doaj.art-63cbd817e81645f0b42de3964473a8e5 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-17T03:22:57Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-63cbd817e81645f0b42de3964473a8e52022-12-21T22:05:28ZengBMCBMC Research Notes1756-05002021-06-011411610.1186/s13104-021-05659-9Presepsin values and prognostic nutritional index predict mortality in intensive care unit patients with sepsis: a pilot studyYuichiro Shimoyama0Osamu Umegaki1Noriko Kadono2Toshiaki Minami3Department of Anesthesiology, Osaka Medical College, Intensive Care Unit, Osaka Medical College HospitalDepartment of Anesthesiology, Osaka Medical College, Intensive Care Unit, Osaka Medical College HospitalDepartment of Anesthesiology, Osaka Medical College, Intensive Care Unit, Osaka Medical College HospitalDepartment of Anesthesiology, Osaka Medical College, Osaka Medical College HospitalAbstract Objective Sepsis is a major cause of mortality for critically ill patients. This study aimed to determine whether presepsin values can predict mortality in patients with sepsis. Results Receiver operating characteristic (ROC) curve analysis, Log-rank test, and multivariate analysis identified presepsin values and Prognostic Nutritional Index as predictors of mortality in sepsis patients. Presepsin value on Day 1 was a predictor of early mortality, i.e., death within 7 days of ICU admission; ROC curve analysis revealed an AUC of 0.84, sensitivity of 89%, and specificity of 77%; and multivariate analysis showed an OR of 1.0007, with a 95%CI of 1.0001–1.0013 (p = 0.0320).https://doi.org/10.1186/s13104-021-05659-9PresepsinSepsisSepsis-3 definitionInflammation-based prognostic scoreMortality |
| spellingShingle | Yuichiro Shimoyama Osamu Umegaki Noriko Kadono Toshiaki Minami Presepsin values and prognostic nutritional index predict mortality in intensive care unit patients with sepsis: a pilot study BMC Research Notes Presepsin Sepsis Sepsis-3 definition Inflammation-based prognostic score Mortality |
| title | Presepsin values and prognostic nutritional index predict mortality in intensive care unit patients with sepsis: a pilot study |
| title_full | Presepsin values and prognostic nutritional index predict mortality in intensive care unit patients with sepsis: a pilot study |
| title_fullStr | Presepsin values and prognostic nutritional index predict mortality in intensive care unit patients with sepsis: a pilot study |
| title_full_unstemmed | Presepsin values and prognostic nutritional index predict mortality in intensive care unit patients with sepsis: a pilot study |
| title_short | Presepsin values and prognostic nutritional index predict mortality in intensive care unit patients with sepsis: a pilot study |
| title_sort | presepsin values and prognostic nutritional index predict mortality in intensive care unit patients with sepsis a pilot study |
| topic | Presepsin Sepsis Sepsis-3 definition Inflammation-based prognostic score Mortality |
| url | https://doi.org/10.1186/s13104-021-05659-9 |
| work_keys_str_mv | AT yuichiroshimoyama presepsinvaluesandprognosticnutritionalindexpredictmortalityinintensivecareunitpatientswithsepsisapilotstudy AT osamuumegaki presepsinvaluesandprognosticnutritionalindexpredictmortalityinintensivecareunitpatientswithsepsisapilotstudy AT norikokadono presepsinvaluesandprognosticnutritionalindexpredictmortalityinintensivecareunitpatientswithsepsisapilotstudy AT toshiakiminami presepsinvaluesandprognosticnutritionalindexpredictmortalityinintensivecareunitpatientswithsepsisapilotstudy |