Distinct non-clock-like signatures of the basal cell carcinomas from three sisters with a lethal Gorlin-Goltz syndrome

Distinct non-clock-like signatures of the basal cell carcinomas from three sisters with a lethal Gorlin-Goltz syndrome

Abstract Background Gorlin-Goltz syndrome (GS) is an inherited disease characterized by predisposition to basal cell carcinomas (BCCs) and various developmental defects, whose numerous disease-causing PTCH1 mutations have been identified in the hedgehog (Hh) signaling pathway. Methods In this study,...

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Bibliographic Details
Main Authors: Lihua Ye, Li Wang, Kexin Peng, Ou Fang, Zhen Tian, Caihua Li, Xiaopeng Fu, Qingdong Chen, Jia Chen, Jing Luan, Zhenghua Zhang, Qiaoan Zhang
Format: Article
Language:English
Published: BMC 2022-08-01
Series:BMC Medical Genomics
Subjects:
Gorlin-Goltz syndrome
PTCH1
Mutational signatures
Online Access:https://doi.org/10.1186/s12920-022-01324-7

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