Neuroimaging evaluation of deep brain stimulation in the treatment of representative neurodegenerative and neuropsychiatric disorders
Abstract Brain stimulation technology has become a viable modality of reversible interventions in the effective treatment of many neurological and psychiatric disorders. It is aimed to restore brain dysfunction by the targeted delivery of specific electronic signal within or outside the brain to mod...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | Bioelectronic Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42234-021-00065-9 |
| _version_ | 1828937824038027264 |
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| author | Shichun Peng Vijay Dhawan David Eidelberg Yilong Ma |
| author_facet | Shichun Peng Vijay Dhawan David Eidelberg Yilong Ma |
| author_sort | Shichun Peng |
| collection | DOAJ |
| description | Abstract Brain stimulation technology has become a viable modality of reversible interventions in the effective treatment of many neurological and psychiatric disorders. It is aimed to restore brain dysfunction by the targeted delivery of specific electronic signal within or outside the brain to modulate neural activity on local and circuit levels. Development of therapeutic approaches with brain stimulation goes in tandem with the use of neuroimaging methodology in every step of the way. Indeed, multimodality neuroimaging tools have played important roles in target identification, neurosurgical planning, placement of stimulators and post-operative confirmation. They have also been indispensable in pre-treatment screen to identify potential responders and in post-treatment to assess the modulation of brain circuitry in relation to clinical outcome measures. Studies in patients to date have elucidated novel neurobiological mechanisms underlying the neuropathogenesis, action of stimulations, brain responses and therapeutic efficacy. In this article, we review some applications of deep brain stimulation for the treatment of several diseases in the field of neurology and psychiatry. We highlight how the synergistic combination of brain stimulation and neuroimaging technology is posed to accelerate the development of symptomatic therapies and bring revolutionary advances in the domain of bioelectronic medicine. |
| first_indexed | 2024-12-14T02:31:05Z |
| format | Article |
| id | doaj.art-63cc73922dfe438cbfd7ea9b0be7278f |
| institution | Directory Open Access Journal |
| issn | 2332-8886 |
| language | English |
| last_indexed | 2024-12-14T02:31:05Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Bioelectronic Medicine |
| spelling | doaj.art-63cc73922dfe438cbfd7ea9b0be7278f2022-12-21T23:20:15ZengBMCBioelectronic Medicine2332-88862021-03-017111810.1186/s42234-021-00065-9Neuroimaging evaluation of deep brain stimulation in the treatment of representative neurodegenerative and neuropsychiatric disordersShichun Peng0Vijay Dhawan1David Eidelberg2Yilong Ma3Center for Neurosciences, Institute of Molecular Medicine, The Feinstein Institutes for Medical ResearchCenter for Neurosciences, Institute of Molecular Medicine, The Feinstein Institutes for Medical ResearchCenter for Neurosciences, Institute of Molecular Medicine, The Feinstein Institutes for Medical ResearchCenter for Neurosciences, Institute of Molecular Medicine, The Feinstein Institutes for Medical ResearchAbstract Brain stimulation technology has become a viable modality of reversible interventions in the effective treatment of many neurological and psychiatric disorders. It is aimed to restore brain dysfunction by the targeted delivery of specific electronic signal within or outside the brain to modulate neural activity on local and circuit levels. Development of therapeutic approaches with brain stimulation goes in tandem with the use of neuroimaging methodology in every step of the way. Indeed, multimodality neuroimaging tools have played important roles in target identification, neurosurgical planning, placement of stimulators and post-operative confirmation. They have also been indispensable in pre-treatment screen to identify potential responders and in post-treatment to assess the modulation of brain circuitry in relation to clinical outcome measures. Studies in patients to date have elucidated novel neurobiological mechanisms underlying the neuropathogenesis, action of stimulations, brain responses and therapeutic efficacy. In this article, we review some applications of deep brain stimulation for the treatment of several diseases in the field of neurology and psychiatry. We highlight how the synergistic combination of brain stimulation and neuroimaging technology is posed to accelerate the development of symptomatic therapies and bring revolutionary advances in the domain of bioelectronic medicine.https://doi.org/10.1186/s42234-021-00065-9Multimodality neuroimagingPETSPECTMRIDTIDeep brain stimulation |
| spellingShingle | Shichun Peng Vijay Dhawan David Eidelberg Yilong Ma Neuroimaging evaluation of deep brain stimulation in the treatment of representative neurodegenerative and neuropsychiatric disorders Bioelectronic Medicine Multimodality neuroimaging PET SPECT MRI DTI Deep brain stimulation |
| title | Neuroimaging evaluation of deep brain stimulation in the treatment of representative neurodegenerative and neuropsychiatric disorders |
| title_full | Neuroimaging evaluation of deep brain stimulation in the treatment of representative neurodegenerative and neuropsychiatric disorders |
| title_fullStr | Neuroimaging evaluation of deep brain stimulation in the treatment of representative neurodegenerative and neuropsychiatric disorders |
| title_full_unstemmed | Neuroimaging evaluation of deep brain stimulation in the treatment of representative neurodegenerative and neuropsychiatric disorders |
| title_short | Neuroimaging evaluation of deep brain stimulation in the treatment of representative neurodegenerative and neuropsychiatric disorders |
| title_sort | neuroimaging evaluation of deep brain stimulation in the treatment of representative neurodegenerative and neuropsychiatric disorders |
| topic | Multimodality neuroimaging PET SPECT MRI DTI Deep brain stimulation |
| url | https://doi.org/10.1186/s42234-021-00065-9 |
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