Correlation between cognitive impairment and serum phosphorylated tau181 protein in patients with preeclampsia
ObjectiveTo study the cognitive function status, serum phosphorylated tau181 (P-tau181) protein level, and total tau (T-tau) protein level in patients with preeclampsia (PE), pregnant healthy controls (PHCs), and non-pregnant healthy controls (NPHCs), and to research their feasibility as serum bioma...
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| Format: | Article |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1148518/full |
| _version_ | 1797858943904514048 |
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| author | Yuanyuan Wang Bin Guo Ke Zhao Linfeng Yang Tao Chen |
| author_facet | Yuanyuan Wang Bin Guo Ke Zhao Linfeng Yang Tao Chen |
| author_sort | Yuanyuan Wang |
| collection | DOAJ |
| description | ObjectiveTo study the cognitive function status, serum phosphorylated tau181 (P-tau181) protein level, and total tau (T-tau) protein level in patients with preeclampsia (PE), pregnant healthy controls (PHCs), and non-pregnant healthy controls (NPHCs), and to research their feasibility as serum biomarkers for evaluating cognitive functional impairment in PE patients.MethodsSixty-eight patients with PE, 48 NPHCs, and 30 PHCs were included. Cognitive functional status was assessed using standardized Symbol Digit Modalities Test (SDMT) and Montreal Cognitive Assessment (MoCA) scales. Enzyme-linked immunosorbent assay (ELISA) was used to detect the level of serum P-tau181 and T-tau protein. The concentration of serum P-tau181 and T-tau protein were compared by one-way analysis of variance in the three groups of subjects. The correlation between P-tau181, T-tau, and SDMT was explore by multiple linear regression analysis. The areas under the receiver operating characteristic (ROC) curves of serum P-tau181 and SDMT were calculated to predict the cognitive level of subjects.ResultsPE patients significantly had lower scores on SDMT (47.97 ± 7.54) and MoCA (28.00 ± 2.00) than normotensive PHCs (30.00 ± 1.25, 54.73 ± 8.55, respectively). The significant difference was found in serum P-tau181 protein levels among the three groups [H(K) = 19.101, P < 0.001]. Serum P-tau181 was thicker in PE patients than PHCs or NPHCs (both P < 0.05). According to the ROC curve, T-tau had no statistical significance in predicting the ability of cognizance, while P-tau181 and SDMT had. The DeLong test showed that P-tau181 was better than T-tau in predicting the ability of cognizance (P < 0.05).ConclusionThe patients with PE have occurred the decline of cognitive function during pregnancy. The high level of serum P-tau181 can be used as a clinical laboratory indication for non-invasive assessment of cognitive functional impairment in PE patients. |
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| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-09T21:21:33Z |
| publishDate | 2023-03-01 |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-63ccd409890a4a96b2cb85b388a2e3a12023-03-28T05:24:50ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-03-011510.3389/fnagi.2023.11485181148518Correlation between cognitive impairment and serum phosphorylated tau181 protein in patients with preeclampsiaYuanyuan Wang0Bin Guo1Ke Zhao2Linfeng Yang3Tao Chen4Department of Radiology, Binzhou Medical University, Yantai, Shandong, ChinaDepartment of Radiology, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaDepartment of Clinical Laboratory, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaDepartment of Radiology, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaDepartment of Clinical Laboratory, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaObjectiveTo study the cognitive function status, serum phosphorylated tau181 (P-tau181) protein level, and total tau (T-tau) protein level in patients with preeclampsia (PE), pregnant healthy controls (PHCs), and non-pregnant healthy controls (NPHCs), and to research their feasibility as serum biomarkers for evaluating cognitive functional impairment in PE patients.MethodsSixty-eight patients with PE, 48 NPHCs, and 30 PHCs were included. Cognitive functional status was assessed using standardized Symbol Digit Modalities Test (SDMT) and Montreal Cognitive Assessment (MoCA) scales. Enzyme-linked immunosorbent assay (ELISA) was used to detect the level of serum P-tau181 and T-tau protein. The concentration of serum P-tau181 and T-tau protein were compared by one-way analysis of variance in the three groups of subjects. The correlation between P-tau181, T-tau, and SDMT was explore by multiple linear regression analysis. The areas under the receiver operating characteristic (ROC) curves of serum P-tau181 and SDMT were calculated to predict the cognitive level of subjects.ResultsPE patients significantly had lower scores on SDMT (47.97 ± 7.54) and MoCA (28.00 ± 2.00) than normotensive PHCs (30.00 ± 1.25, 54.73 ± 8.55, respectively). The significant difference was found in serum P-tau181 protein levels among the three groups [H(K) = 19.101, P < 0.001]. Serum P-tau181 was thicker in PE patients than PHCs or NPHCs (both P < 0.05). According to the ROC curve, T-tau had no statistical significance in predicting the ability of cognizance, while P-tau181 and SDMT had. The DeLong test showed that P-tau181 was better than T-tau in predicting the ability of cognizance (P < 0.05).ConclusionThe patients with PE have occurred the decline of cognitive function during pregnancy. The high level of serum P-tau181 can be used as a clinical laboratory indication for non-invasive assessment of cognitive functional impairment in PE patients.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1148518/fullpreeclampsiacognitive functiontau proteinserum phosphorylated tau181 protein (P-tau181)Symbol Digit Modalities Test (SDMT) |
| spellingShingle | Yuanyuan Wang Bin Guo Ke Zhao Linfeng Yang Tao Chen Correlation between cognitive impairment and serum phosphorylated tau181 protein in patients with preeclampsia Frontiers in Aging Neuroscience preeclampsia cognitive function tau protein serum phosphorylated tau181 protein (P-tau181) Symbol Digit Modalities Test (SDMT) |
| title | Correlation between cognitive impairment and serum phosphorylated tau181 protein in patients with preeclampsia |
| title_full | Correlation between cognitive impairment and serum phosphorylated tau181 protein in patients with preeclampsia |
| title_fullStr | Correlation between cognitive impairment and serum phosphorylated tau181 protein in patients with preeclampsia |
| title_full_unstemmed | Correlation between cognitive impairment and serum phosphorylated tau181 protein in patients with preeclampsia |
| title_short | Correlation between cognitive impairment and serum phosphorylated tau181 protein in patients with preeclampsia |
| title_sort | correlation between cognitive impairment and serum phosphorylated tau181 protein in patients with preeclampsia |
| topic | preeclampsia cognitive function tau protein serum phosphorylated tau181 protein (P-tau181) Symbol Digit Modalities Test (SDMT) |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1148518/full |
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