STING Contributes to Cancer-Induced Bone Pain by Promoting M1 Polarization of Microglia in the Medial Prefrontal Cortex

STING Contributes to Cancer-Induced Bone Pain by Promoting M1 Polarization of Microglia in the Medial Prefrontal Cortex

The medial prefrontal cortex (mPFC) is the main cortical area for processing both sensory and affective aspects of pain. Recently, mPFC was reported to participate in cancer-induced bone pain (CIBP) via the mechanism of central inflammation. STING is a key component of neuroinflammation in the centr...

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Bibliographic Details
Main Authors: Xiaoxuan Zhang, Xin Li, Wei Wang, Yuxin Zhang, Zhihao Gong, Yuan Peng, Jingxiang Wu, Xingji You
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
medial prefrontal cortex
STING
M1 microglia
cancer-induced bone pain
Online Access:https://www.mdpi.com/2072-6694/14/21/5188

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