Inflammation—A Possible Link between Myocarditis and Arrhythmogenic Cardiomyopathy
Arrhythmogenic cardiomyopathy is a primary genetic disease caused by mutations in the desmosome genes. Ever since the introduction of new imaging techniques, like cardiovascular magnetic resonance, the diagnosis of arrhythmogenic cardiomyopathy has become more challenging as left ventricular or bive...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/14/3/248 |
| _version_ | 1797318929567186944 |
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| author | Ioan Radu Lala Adina Pop-Moldovan |
| author_facet | Ioan Radu Lala Adina Pop-Moldovan |
| author_sort | Ioan Radu Lala |
| collection | DOAJ |
| description | Arrhythmogenic cardiomyopathy is a primary genetic disease caused by mutations in the desmosome genes. Ever since the introduction of new imaging techniques, like cardiovascular magnetic resonance, the diagnosis of arrhythmogenic cardiomyopathy has become more challenging as left ventricular or biventricular variants may have resemblance to other cardiomyopathies or myocarditis. Not only this but they may also share an acute phase, which might cause even more confusion and misdiagnoses and influence the prognosis and outcome. In this case report, we present a 31-year-old patient with multiple clinical pictures: his symptoms were acute chest pain, new onset of heart failure and arrhythmia symptoms, which determined a dynamic change in clinical diagnosis and management, ultimately taking into consideration arrhythmogenic cardiomyopathy. Through the article, we try to uncover and explain common pathophysiological pathways shared by arrhythmogenic cardiomyopathy and other clinical entities with a special focus on inflammation. The final question remains: <i>“If there is more than one heart disorder that eventually leads to the same clinical image, one may wonder, is arrhythmogenic cardiomyopathy a syndrome rather than a specific condition?”.</i> |
| first_indexed | 2024-03-08T03:59:34Z |
| format | Article |
| id | doaj.art-63cfae63d9c6496aa4478bf2af0d33af |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-08T03:59:34Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-63cfae63d9c6496aa4478bf2af0d33af2024-02-09T15:09:57ZengMDPI AGDiagnostics2075-44182024-01-0114324810.3390/diagnostics14030248Inflammation—A Possible Link between Myocarditis and Arrhythmogenic CardiomyopathyIoan Radu Lala0Adina Pop-Moldovan1Departement of Cardiology, Arad Emergency Clinical County Hospital, 310037 Arad, RomaniaDepartement of Cardiology, Arad Emergency Clinical County Hospital, 310037 Arad, RomaniaArrhythmogenic cardiomyopathy is a primary genetic disease caused by mutations in the desmosome genes. Ever since the introduction of new imaging techniques, like cardiovascular magnetic resonance, the diagnosis of arrhythmogenic cardiomyopathy has become more challenging as left ventricular or biventricular variants may have resemblance to other cardiomyopathies or myocarditis. Not only this but they may also share an acute phase, which might cause even more confusion and misdiagnoses and influence the prognosis and outcome. In this case report, we present a 31-year-old patient with multiple clinical pictures: his symptoms were acute chest pain, new onset of heart failure and arrhythmia symptoms, which determined a dynamic change in clinical diagnosis and management, ultimately taking into consideration arrhythmogenic cardiomyopathy. Through the article, we try to uncover and explain common pathophysiological pathways shared by arrhythmogenic cardiomyopathy and other clinical entities with a special focus on inflammation. The final question remains: <i>“If there is more than one heart disorder that eventually leads to the same clinical image, one may wonder, is arrhythmogenic cardiomyopathy a syndrome rather than a specific condition?”.</i>https://www.mdpi.com/2075-4418/14/3/248inflammationmyocarditisarrhythmogenic cardiomyopathycardiovascular magnetic resonance |
| spellingShingle | Ioan Radu Lala Adina Pop-Moldovan Inflammation—A Possible Link between Myocarditis and Arrhythmogenic Cardiomyopathy Diagnostics inflammation myocarditis arrhythmogenic cardiomyopathy cardiovascular magnetic resonance |
| title | Inflammation—A Possible Link between Myocarditis and Arrhythmogenic Cardiomyopathy |
| title_full | Inflammation—A Possible Link between Myocarditis and Arrhythmogenic Cardiomyopathy |
| title_fullStr | Inflammation—A Possible Link between Myocarditis and Arrhythmogenic Cardiomyopathy |
| title_full_unstemmed | Inflammation—A Possible Link between Myocarditis and Arrhythmogenic Cardiomyopathy |
| title_short | Inflammation—A Possible Link between Myocarditis and Arrhythmogenic Cardiomyopathy |
| title_sort | inflammation a possible link between myocarditis and arrhythmogenic cardiomyopathy |
| topic | inflammation myocarditis arrhythmogenic cardiomyopathy cardiovascular magnetic resonance |
| url | https://www.mdpi.com/2075-4418/14/3/248 |
| work_keys_str_mv | AT ioanradulala inflammationapossiblelinkbetweenmyocarditisandarrhythmogeniccardiomyopathy AT adinapopmoldovan inflammationapossiblelinkbetweenmyocarditisandarrhythmogeniccardiomyopathy |