Outer Membrane Vesicles from <i>Acinetobacter baumannii</i>: Biogenesis, Functions, and Vaccine Application
This review focuses on <i>Acinetobacter baumannii</i>, a Gram-negative bacterium that causes various infections and whose multidrug resistance has become a significant challenge in clinical practices. There are multiple bacterial mechanisms in <i>A. baumannii</i> that partici...
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| Format: | Article |
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MDPI AG
2023-12-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/12/1/49 |
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| author | Zheqi Weng Ning Yang Shujun Shi Zining Xu Zixu Chen Chen Liang Xiuwei Zhang Xingran Du |
| author_facet | Zheqi Weng Ning Yang Shujun Shi Zining Xu Zixu Chen Chen Liang Xiuwei Zhang Xingran Du |
| author_sort | Zheqi Weng |
| collection | DOAJ |
| description | This review focuses on <i>Acinetobacter baumannii</i>, a Gram-negative bacterium that causes various infections and whose multidrug resistance has become a significant challenge in clinical practices. There are multiple bacterial mechanisms in <i>A. baumannii</i> that participate in bacterial colonization and immune responses. It is believed that outer membrane vesicles (OMVs) budding from the bacteria play a significant role in mediating bacterial survival and the subsequent attack against the host. Most OMVs originate from the bacterial membranes and molecules are enveloped in them. Elements similar to the pathogen endow OMVs with robust virulence, which provides a new direction for exploring the pathogenicity of <i>A. baumannii</i> and its therapeutic pathways. Although extensive research has been carried out on the feasibility of OMV-based vaccines against pathogens, no study has yet summarized the bioactive elements, biological activity, and vaccine applicability of <i>A. baumannii</i> OMVs. This review summarizes the components, biogenesis, and function of OMVs that contribute to their potential as vaccine candidates and the preparation methods and future directions for their development. |
| first_indexed | 2024-03-08T09:44:38Z |
| format | Article |
| id | doaj.art-63d12b6d73184d8a946983908af160c4 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-08T09:44:38Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-63d12b6d73184d8a946983908af160c42024-01-29T14:25:34ZengMDPI AGVaccines2076-393X2023-12-011214910.3390/vaccines12010049Outer Membrane Vesicles from <i>Acinetobacter baumannii</i>: Biogenesis, Functions, and Vaccine ApplicationZheqi Weng0Ning Yang1Shujun Shi2Zining Xu3Zixu Chen4Chen Liang5Xiuwei Zhang6Xingran Du7The Second Clinical Medical School, Nanjing Medical University, Nanjing 210011, ChinaDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, ChinaThe Second Clinical Medical School, Nanjing Medical University, Nanjing 210011, ChinaThe Second Clinical Medical School, Nanjing Medical University, Nanjing 210011, ChinaThe Second Clinical Medical School, Nanjing Medical University, Nanjing 210011, ChinaThe Second Clinical Medical School, Nanjing Medical University, Nanjing 210011, ChinaDepartment of Respiratory and Critical Care Medicine, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing 211100, ChinaDepartment of Respiratory and Critical Care Medicine, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing 211100, ChinaThis review focuses on <i>Acinetobacter baumannii</i>, a Gram-negative bacterium that causes various infections and whose multidrug resistance has become a significant challenge in clinical practices. There are multiple bacterial mechanisms in <i>A. baumannii</i> that participate in bacterial colonization and immune responses. It is believed that outer membrane vesicles (OMVs) budding from the bacteria play a significant role in mediating bacterial survival and the subsequent attack against the host. Most OMVs originate from the bacterial membranes and molecules are enveloped in them. Elements similar to the pathogen endow OMVs with robust virulence, which provides a new direction for exploring the pathogenicity of <i>A. baumannii</i> and its therapeutic pathways. Although extensive research has been carried out on the feasibility of OMV-based vaccines against pathogens, no study has yet summarized the bioactive elements, biological activity, and vaccine applicability of <i>A. baumannii</i> OMVs. This review summarizes the components, biogenesis, and function of OMVs that contribute to their potential as vaccine candidates and the preparation methods and future directions for their development.https://www.mdpi.com/2076-393X/12/1/49<i>Acinetobacter baumannii</i>outer membrane vesiclesbiogenesisantibiotic resistance |
| spellingShingle | Zheqi Weng Ning Yang Shujun Shi Zining Xu Zixu Chen Chen Liang Xiuwei Zhang Xingran Du Outer Membrane Vesicles from <i>Acinetobacter baumannii</i>: Biogenesis, Functions, and Vaccine Application Vaccines <i>Acinetobacter baumannii</i> outer membrane vesicles biogenesis antibiotic resistance |
| title | Outer Membrane Vesicles from <i>Acinetobacter baumannii</i>: Biogenesis, Functions, and Vaccine Application |
| title_full | Outer Membrane Vesicles from <i>Acinetobacter baumannii</i>: Biogenesis, Functions, and Vaccine Application |
| title_fullStr | Outer Membrane Vesicles from <i>Acinetobacter baumannii</i>: Biogenesis, Functions, and Vaccine Application |
| title_full_unstemmed | Outer Membrane Vesicles from <i>Acinetobacter baumannii</i>: Biogenesis, Functions, and Vaccine Application |
| title_short | Outer Membrane Vesicles from <i>Acinetobacter baumannii</i>: Biogenesis, Functions, and Vaccine Application |
| title_sort | outer membrane vesicles from i acinetobacter baumannii i biogenesis functions and vaccine application |
| topic | <i>Acinetobacter baumannii</i> outer membrane vesicles biogenesis antibiotic resistance |
| url | https://www.mdpi.com/2076-393X/12/1/49 |
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