Short-Chain Fatty Acids (Except Hexanoic Acid) Lower NF-kB Transactivation, Which Rescues Inflammation-Induced Decreased Apolipoprotein A-I Transcription in HepG2 Cells

Short-Chain Fatty Acids (Except Hexanoic Acid) Lower NF-kB Transactivation, Which Rescues Inflammation-Induced Decreased Apolipoprotein A-I Transcription in HepG2 Cells

Concentrations of apolipoprotein A-I (ApoA-I) decrease during inflammation, which may lead to dysfunctional ApoA-I-poor high-density lipoprotein (HDL) particles, and as such, elevate cardiovascular risk. Therefore, rescuing ApoA-I concentrations, especially during inflammation, seems beneficial. Rec...

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Bibliographic Details
Main Authors: Jehad Z. Tayyeb, Herman E. Popeijus, Ronald P. Mensink, Maurice C. J. M. Konings, Fatma B. A. Mokhtar, Jogchum Plat
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
ApoA-I
inflammation
NF-κB
PPARα
SCFAs
Online Access:https://www.mdpi.com/1422-0067/21/14/5088

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