Multimerization through Pegylation Improves Pharmacokinetic Properties of scFv Fragments of GD2-Specific Antibodies

Multimerization through Pegylation Improves Pharmacokinetic Properties of scFv Fragments of GD2-Specific Antibodies

Antigen-binding fragments of antibodies specific to the tumor-associated ganglioside GD2 are well poised to play a substantial role in modern GD2-targeted cancer therapies, however, rapid elimination from the body and reduced affinity compared to full-length antibodies limit their therapeutic potent...

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Bibliographic Details
Main Authors: Irina V. Kholodenko, Daniel V. Kalinovsky, Elena V. Svirshchevskaya, Igor I. Doronin, Maria V. Konovalova, Alexey V. Kibardin, Tatyana V. Shamanskaya, Sergey S. Larin, Sergey M. Deyev, Roman V. Kholodenko
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Molecules
Subjects:
antibody fragments
pegylation
multimerization
ganglioside gd2
immunotherapy
cancer
neuroblastoma
Online Access:https://www.mdpi.com/1420-3049/24/21/3835

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