Systematic Elucidation of the Aneuploidy Landscape and Identification of Aneuploidy Driver Genes in Prostate Cancer
Aneuploidy is widely identified as a remarkable feature of malignancy genomes. Increasing evidences suggested aneuploidy was involved in the progression and metastasis of prostate cancer (PCa). Nevertheless, no comprehensive analysis was conducted in PCa about the effects of aneuploidy on different...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-01-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.723466/full |
| _version_ | 1818332529764073472 |
|---|---|
| author | Yun Peng Yuxuan Song Haitao Wang |
| author_facet | Yun Peng Yuxuan Song Haitao Wang |
| author_sort | Yun Peng |
| collection | DOAJ |
| description | Aneuploidy is widely identified as a remarkable feature of malignancy genomes. Increasing evidences suggested aneuploidy was involved in the progression and metastasis of prostate cancer (PCa). Nevertheless, no comprehensive analysis was conducted in PCa about the effects of aneuploidy on different omics and, especially, about the driver genes of aneuploidy. Here, we validated the association of aneuploidy with the progression and prognosis of PCa and performed a systematic analysis in mutation profile, methylation profile, and gene expression profile, which detailed the molecular process aneuploidy implicated. By multi-omics analysis, we managed to identify 11 potential aneuploidy driver genes (GSTM2, HAAO, C2orf88, CYP27A1, FAXDC2, HFE, C8orf88, GSTP1, EFS, HIF3A, and WFDC2), all of which were related to the development and metastasis of PCa. Meanwhile, we also found aneuploidy and its driver genes were correlated with the immune microenvironment of PCa. Our findings could shed light on the tumorigenesis of PCa and provide a better understanding of the development and metastasis of PCa; additionally, the driver genes could be promising and actionable therapeutic targets pointing to aneuploidy. |
| first_indexed | 2024-12-13T13:37:12Z |
| format | Article |
| id | doaj.art-63d8bb753b9d4148bfc2b0946e9984a8 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-13T13:37:12Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-63d8bb753b9d4148bfc2b0946e9984a82022-12-21T23:43:43ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-01-01910.3389/fcell.2021.723466723466Systematic Elucidation of the Aneuploidy Landscape and Identification of Aneuploidy Driver Genes in Prostate CancerYun Peng0Yuxuan Song1Haitao Wang2Tianjin Institute of Urology, the 2nd Hospital of Tianjin Medical University, Tianjin, ChinaDepartment of Urology, Peking University People’s Hospital, Beijing, ChinaDepartment of Oncology, the 2nd Hospital of Tianjin Medical University, Tianjin, ChinaAneuploidy is widely identified as a remarkable feature of malignancy genomes. Increasing evidences suggested aneuploidy was involved in the progression and metastasis of prostate cancer (PCa). Nevertheless, no comprehensive analysis was conducted in PCa about the effects of aneuploidy on different omics and, especially, about the driver genes of aneuploidy. Here, we validated the association of aneuploidy with the progression and prognosis of PCa and performed a systematic analysis in mutation profile, methylation profile, and gene expression profile, which detailed the molecular process aneuploidy implicated. By multi-omics analysis, we managed to identify 11 potential aneuploidy driver genes (GSTM2, HAAO, C2orf88, CYP27A1, FAXDC2, HFE, C8orf88, GSTP1, EFS, HIF3A, and WFDC2), all of which were related to the development and metastasis of PCa. Meanwhile, we also found aneuploidy and its driver genes were correlated with the immune microenvironment of PCa. Our findings could shed light on the tumorigenesis of PCa and provide a better understanding of the development and metastasis of PCa; additionally, the driver genes could be promising and actionable therapeutic targets pointing to aneuploidy.https://www.frontiersin.org/articles/10.3389/fcell.2021.723466/fullprostate canceraneuploidydriver genebiomarkerprognosis (carcinoma)tumor development and progression |
| spellingShingle | Yun Peng Yuxuan Song Haitao Wang Systematic Elucidation of the Aneuploidy Landscape and Identification of Aneuploidy Driver Genes in Prostate Cancer Frontiers in Cell and Developmental Biology prostate cancer aneuploidy driver gene biomarker prognosis (carcinoma) tumor development and progression |
| title | Systematic Elucidation of the Aneuploidy Landscape and Identification of Aneuploidy Driver Genes in Prostate Cancer |
| title_full | Systematic Elucidation of the Aneuploidy Landscape and Identification of Aneuploidy Driver Genes in Prostate Cancer |
| title_fullStr | Systematic Elucidation of the Aneuploidy Landscape and Identification of Aneuploidy Driver Genes in Prostate Cancer |
| title_full_unstemmed | Systematic Elucidation of the Aneuploidy Landscape and Identification of Aneuploidy Driver Genes in Prostate Cancer |
| title_short | Systematic Elucidation of the Aneuploidy Landscape and Identification of Aneuploidy Driver Genes in Prostate Cancer |
| title_sort | systematic elucidation of the aneuploidy landscape and identification of aneuploidy driver genes in prostate cancer |
| topic | prostate cancer aneuploidy driver gene biomarker prognosis (carcinoma) tumor development and progression |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.723466/full |
| work_keys_str_mv | AT yunpeng systematicelucidationoftheaneuploidylandscapeandidentificationofaneuploidydrivergenesinprostatecancer AT yuxuansong systematicelucidationoftheaneuploidylandscapeandidentificationofaneuploidydrivergenesinprostatecancer AT haitaowang systematicelucidationoftheaneuploidylandscapeandidentificationofaneuploidydrivergenesinprostatecancer |