Prevention of malaria in pregnancy: The threat of sulfadoxine-pyrimethamine resistance
Malaria infection in pregnancy can lead to adverse outcomes for both the pregnant person and fetus. The administration of intermittent preventative therapy (IPTp) with sulfadoxine-pyrimethamine (SP) during pregnancy (IPTp-SP) improves outcomes, including severe maternal anemia, placental malaria inf...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.966402/full |
| _version_ | 1811214721453391872 |
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| author | Sesh A. Sundararaman Audrey R. Odom John |
| author_facet | Sesh A. Sundararaman Audrey R. Odom John |
| author_sort | Sesh A. Sundararaman |
| collection | DOAJ |
| description | Malaria infection in pregnancy can lead to adverse outcomes for both the pregnant person and fetus. The administration of intermittent preventative therapy (IPTp) with sulfadoxine-pyrimethamine (SP) during pregnancy (IPTp-SP) improves outcomes, including severe maternal anemia, placental malaria infection, and low infant birth weight. The WHO recommends IPTp-SP for pregnant individuals living in areas of moderate or high malaria transmission in Africa. The current regimen consists of two or more doses of SP starting as early as possible in the second trimester, at least 1 month apart. Unfortunately, rising Plasmodium falciparum SP resistance throughout Africa threatens to erode the benefits of SP. Recent studies have shown a decrease in IPTp-SP efficacy in areas with high SP resistance. Thus, there is an urgent need to identify new drug regimens that can be used for intermittent preventative therapy in pregnancy. In this review, we discuss recent data on P. falciparum SP resistance in Africa, the effect of resistance on IPTp-SP, and studies of alternative IPTp regimens. Finally, we present a framework for the ideal pharmacokinetic and pharmacodynamic properties for future IPTp regimens. |
| first_indexed | 2024-04-12T06:08:14Z |
| format | Article |
| id | doaj.art-63d8fc72dc3d467caa6180deff61a492 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-12T06:08:14Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-63d8fc72dc3d467caa6180deff61a4922022-12-22T03:44:46ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-08-011010.3389/fped.2022.966402966402Prevention of malaria in pregnancy: The threat of sulfadoxine-pyrimethamine resistanceSesh A. SundararamanAudrey R. Odom JohnMalaria infection in pregnancy can lead to adverse outcomes for both the pregnant person and fetus. The administration of intermittent preventative therapy (IPTp) with sulfadoxine-pyrimethamine (SP) during pregnancy (IPTp-SP) improves outcomes, including severe maternal anemia, placental malaria infection, and low infant birth weight. The WHO recommends IPTp-SP for pregnant individuals living in areas of moderate or high malaria transmission in Africa. The current regimen consists of two or more doses of SP starting as early as possible in the second trimester, at least 1 month apart. Unfortunately, rising Plasmodium falciparum SP resistance throughout Africa threatens to erode the benefits of SP. Recent studies have shown a decrease in IPTp-SP efficacy in areas with high SP resistance. Thus, there is an urgent need to identify new drug regimens that can be used for intermittent preventative therapy in pregnancy. In this review, we discuss recent data on P. falciparum SP resistance in Africa, the effect of resistance on IPTp-SP, and studies of alternative IPTp regimens. Finally, we present a framework for the ideal pharmacokinetic and pharmacodynamic properties for future IPTp regimens.https://www.frontiersin.org/articles/10.3389/fped.2022.966402/fullmalariadrug resistancelow birth weightantimalarialIPTp |
| spellingShingle | Sesh A. Sundararaman Audrey R. Odom John Prevention of malaria in pregnancy: The threat of sulfadoxine-pyrimethamine resistance Frontiers in Pediatrics malaria drug resistance low birth weight antimalarial IPTp |
| title | Prevention of malaria in pregnancy: The threat of sulfadoxine-pyrimethamine resistance |
| title_full | Prevention of malaria in pregnancy: The threat of sulfadoxine-pyrimethamine resistance |
| title_fullStr | Prevention of malaria in pregnancy: The threat of sulfadoxine-pyrimethamine resistance |
| title_full_unstemmed | Prevention of malaria in pregnancy: The threat of sulfadoxine-pyrimethamine resistance |
| title_short | Prevention of malaria in pregnancy: The threat of sulfadoxine-pyrimethamine resistance |
| title_sort | prevention of malaria in pregnancy the threat of sulfadoxine pyrimethamine resistance |
| topic | malaria drug resistance low birth weight antimalarial IPTp |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.966402/full |
| work_keys_str_mv | AT seshasundararaman preventionofmalariainpregnancythethreatofsulfadoxinepyrimethamineresistance AT audreyrodomjohn preventionofmalariainpregnancythethreatofsulfadoxinepyrimethamineresistance |