Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study
Objective: To assess the prevalence of pDDI involving antimicrobials and other standardized drugs in a large general hospital in the interior of São Paulo. Methods: quantitative study, with cross-sectional design and data collection by documentary analysis of hospital prescriptions from April to Jun...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde
2021-06-01
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| Series: | Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde |
| Online Access: | https://www.rbfhss.org.br/sbrafh/article/view/573 |
| _version_ | 1818902382731329536 |
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| author | Larissa PAVANELLO Fátima G. FARHAT Rafaela P. CARVALHO Hellen T. GREGÓRIO |
| author_facet | Larissa PAVANELLO Fátima G. FARHAT Rafaela P. CARVALHO Hellen T. GREGÓRIO |
| author_sort | Larissa PAVANELLO |
| collection | DOAJ |
| description | Objective: To assess the prevalence of pDDI involving antimicrobials and other standardized drugs in a large general hospital in the interior of São Paulo. Methods: quantitative study, with cross-sectional design and data collection by documentary analysis of hospital prescriptions from April to June 2017. Results: 66 clinically relevant pDDI were found, which corresponded to approximately 7.3% of antimicrobial prescriptions, being 93.9% (62) contraindicated / severe and 6.1% (4) moderate. There was no difference in the prevalence of clinically relevant pDDIs between critical and non-critical inpatient, in addition to all contraindicated interactions (10) having occurred in the clinical and surgical units. The most prevalent pDDI were, with respective degrees of documentation, between vancomycin and amikacin (47% - reasonable), clarithromycin and simvastatin (13.6% - good), and ciprofloxacin and simvastatin (7.6% - good). Conclusion: For the proper prevention of potential drug-related problems, mechanisms to guarantee the quality of prescriptions by trained clinical pharmacists are of fundamental importance, in addition to alert systems and drug interaction information for the health team, then ensuring quality pharmacotherapy and patient safety. |
| first_indexed | 2024-12-19T20:34:46Z |
| format | Article |
| id | doaj.art-63d9deb03b604de8b4e5081ba9a6063d |
| institution | Directory Open Access Journal |
| issn | 2179-5924 2316-7750 |
| language | English |
| last_indexed | 2024-12-19T20:34:46Z |
| publishDate | 2021-06-01 |
| publisher | Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde |
| record_format | Article |
| series | Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde |
| spelling | doaj.art-63d9deb03b604de8b4e5081ba9a6063d2022-12-21T20:06:35ZengSociedade Brasileira de Farmácia Hospitalar e Serviços de SaúdeRevista Brasileira de Farmácia Hospitalar e Serviços de Saúde2179-59242316-77502021-06-0112210.30968/rbfhss.2021.122.0573Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional studyLarissa PAVANELLOFátima G. FARHATRafaela P. CARVALHOHellen T. GREGÓRIOObjective: To assess the prevalence of pDDI involving antimicrobials and other standardized drugs in a large general hospital in the interior of São Paulo. Methods: quantitative study, with cross-sectional design and data collection by documentary analysis of hospital prescriptions from April to June 2017. Results: 66 clinically relevant pDDI were found, which corresponded to approximately 7.3% of antimicrobial prescriptions, being 93.9% (62) contraindicated / severe and 6.1% (4) moderate. There was no difference in the prevalence of clinically relevant pDDIs between critical and non-critical inpatient, in addition to all contraindicated interactions (10) having occurred in the clinical and surgical units. The most prevalent pDDI were, with respective degrees of documentation, between vancomycin and amikacin (47% - reasonable), clarithromycin and simvastatin (13.6% - good), and ciprofloxacin and simvastatin (7.6% - good). Conclusion: For the proper prevention of potential drug-related problems, mechanisms to guarantee the quality of prescriptions by trained clinical pharmacists are of fundamental importance, in addition to alert systems and drug interaction information for the health team, then ensuring quality pharmacotherapy and patient safety.https://www.rbfhss.org.br/sbrafh/article/view/573 |
| spellingShingle | Larissa PAVANELLO Fátima G. FARHAT Rafaela P. CARVALHO Hellen T. GREGÓRIO Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde |
| title | Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study |
| title_full | Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study |
| title_fullStr | Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study |
| title_full_unstemmed | Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study |
| title_short | Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study |
| title_sort | clinically relevant drug interactions involving antimicrobials in a general hospital a cross sectional study |
| url | https://www.rbfhss.org.br/sbrafh/article/view/573 |
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