Impact of COVID-19 Pandemic in Antibiotic Consumption in Navarre (Spain): An Interrupted Time Series Analysis
On 11 March 2020, the World Health Organization declared coronavirus disease 19 (COVID-19) a global pandemic. This exceptional situation changed the world not only in terms of mortality and morbidity, but also in terms of epidemiology and health system resources consumption. The objective of this wo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/12/2/318 |
| _version_ | 1797622773661564928 |
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| author | Natalia Alzueta Amaya Echeverría Patricia García Lorea Sanz Alberto Gil-Setas Xabier Beristain Pablo Aldaz Javier Garjón |
| author_facet | Natalia Alzueta Amaya Echeverría Patricia García Lorea Sanz Alberto Gil-Setas Xabier Beristain Pablo Aldaz Javier Garjón |
| author_sort | Natalia Alzueta |
| collection | DOAJ |
| description | On 11 March 2020, the World Health Organization declared coronavirus disease 19 (COVID-19) a global pandemic. This exceptional situation changed the world not only in terms of mortality and morbidity, but also in terms of epidemiology and health system resources consumption. The objective of this work was to analyze the consumption of antibiotics during the period around the pandemic in our region. A drug utilization study was performed comparing the antibiotic consumption in the community during the years 2018, 2019, 2020, and 2021. Quarterly antibiotic use (defined daily doses (DDD) per 1000 inhabitants per day (DID)) and number of patients treated were the outcomes. Interrupted time series regression analysis was performed to estimate the statistical significance of the change in level of consumption before and after the COVID-19 pandemic. The drop of global antibiotic consumption was statistically significant, both in number of patients and in DID when analyzing pre-pandemic period versus pandemic period. The use of strategic antibiotics for respiratory infections such as amoxicillin, amoxicillin-clavulanic acid, and levofloxacin also decreased significantly. Seasonal pattern of use of antibiotics disappeared due to the global measures imposed over the world to work against COVID-19. |
| first_indexed | 2024-03-11T09:15:02Z |
| format | Article |
| id | doaj.art-63da51cdcc4446629bd3f9777934903e |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T09:15:02Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-63da51cdcc4446629bd3f9777934903e2023-11-16T18:43:18ZengMDPI AGAntibiotics2079-63822023-02-0112231810.3390/antibiotics12020318Impact of COVID-19 Pandemic in Antibiotic Consumption in Navarre (Spain): An Interrupted Time Series AnalysisNatalia Alzueta0Amaya Echeverría1Patricia García2Lorea Sanz3Alberto Gil-Setas4Xabier Beristain5Pablo Aldaz6Javier Garjón7Hospital Reina Sofía, Navarre Health Service, 31500 Tudela, SpainIdiSNA, Health Research Institute of Navarre, 31008 Pamplona, SpainIdiSNA, Health Research Institute of Navarre, 31008 Pamplona, SpainIdiSNA, Health Research Institute of Navarre, 31008 Pamplona, SpainIdiSNA, Health Research Institute of Navarre, 31008 Pamplona, SpainIdiSNA, Health Research Institute of Navarre, 31008 Pamplona, SpainIdiSNA, Health Research Institute of Navarre, 31008 Pamplona, SpainIdiSNA, Health Research Institute of Navarre, 31008 Pamplona, SpainOn 11 March 2020, the World Health Organization declared coronavirus disease 19 (COVID-19) a global pandemic. This exceptional situation changed the world not only in terms of mortality and morbidity, but also in terms of epidemiology and health system resources consumption. The objective of this work was to analyze the consumption of antibiotics during the period around the pandemic in our region. A drug utilization study was performed comparing the antibiotic consumption in the community during the years 2018, 2019, 2020, and 2021. Quarterly antibiotic use (defined daily doses (DDD) per 1000 inhabitants per day (DID)) and number of patients treated were the outcomes. Interrupted time series regression analysis was performed to estimate the statistical significance of the change in level of consumption before and after the COVID-19 pandemic. The drop of global antibiotic consumption was statistically significant, both in number of patients and in DID when analyzing pre-pandemic period versus pandemic period. The use of strategic antibiotics for respiratory infections such as amoxicillin, amoxicillin-clavulanic acid, and levofloxacin also decreased significantly. Seasonal pattern of use of antibiotics disappeared due to the global measures imposed over the world to work against COVID-19.https://www.mdpi.com/2079-6382/12/2/318antibioticCOVID-19primary care |
| spellingShingle | Natalia Alzueta Amaya Echeverría Patricia García Lorea Sanz Alberto Gil-Setas Xabier Beristain Pablo Aldaz Javier Garjón Impact of COVID-19 Pandemic in Antibiotic Consumption in Navarre (Spain): An Interrupted Time Series Analysis Antibiotics antibiotic COVID-19 primary care |
| title | Impact of COVID-19 Pandemic in Antibiotic Consumption in Navarre (Spain): An Interrupted Time Series Analysis |
| title_full | Impact of COVID-19 Pandemic in Antibiotic Consumption in Navarre (Spain): An Interrupted Time Series Analysis |
| title_fullStr | Impact of COVID-19 Pandemic in Antibiotic Consumption in Navarre (Spain): An Interrupted Time Series Analysis |
| title_full_unstemmed | Impact of COVID-19 Pandemic in Antibiotic Consumption in Navarre (Spain): An Interrupted Time Series Analysis |
| title_short | Impact of COVID-19 Pandemic in Antibiotic Consumption in Navarre (Spain): An Interrupted Time Series Analysis |
| title_sort | impact of covid 19 pandemic in antibiotic consumption in navarre spain an interrupted time series analysis |
| topic | antibiotic COVID-19 primary care |
| url | https://www.mdpi.com/2079-6382/12/2/318 |
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