Differential effects of a computerized cognitive stimulation program on older adults with mild cognitive impairment according to the severity of white matter hyperintensities
Leila Djabelkhir-Jemmi,1,2 Ya-Huei Wu,1,2 Marouane Boubaya,3 Fabienne Marlats,1,2 Manon Lewis,1 Jean-Sébastien Vidal,1,2 Hermine Lenoir,1,2 Benoit Charlieux,1 Baptiste Isabet,1 Anne-Sophie Rigaud1,2 1Department of Clinical Gerontology, Broca Hospital-APHP, Paris, France; 2Research Team...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-08-01
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| Series: | Clinical Interventions in Aging |
| Subjects: | |
| Online Access: | https://www.dovepress.com/differential-effects-of-a-computerized-cognitive-stimulation-program-o-peer-reviewed-article-CIA |
| _version_ | 1819015780138745856 |
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| author | Djabelkhir-Jemmi L Wu YH Boubaya M Marlats F Lewis M Vidal JS Lenoir H Charlieux B Isabet B Rigaud AS |
| author_facet | Djabelkhir-Jemmi L Wu YH Boubaya M Marlats F Lewis M Vidal JS Lenoir H Charlieux B Isabet B Rigaud AS |
| author_sort | Djabelkhir-Jemmi L |
| collection | DOAJ |
| description | Leila Djabelkhir-Jemmi,1,2 Ya-Huei Wu,1,2 Marouane Boubaya,3 Fabienne Marlats,1,2 Manon Lewis,1 Jean-Sébastien Vidal,1,2 Hermine Lenoir,1,2 Benoit Charlieux,1 Baptiste Isabet,1 Anne-Sophie Rigaud1,2 1Department of Clinical Gerontology, Broca Hospital-APHP, Paris, France; 2Research Team EA 4468, Alzheimer’s Disease, Vascular Risk Factors and Diagnostic Markers, Care and Support for Patients and Families, Institute of Psychology of Paris Descartes University, Paris, France; 3Clinical Research Unit, Avicenne Hospital, Bobigny, France Objective: This study aimed to explore whether a computerized cognitive stimulation program (CCS) induced differential effects in older adults with mild cognitive impairment (MCI) according to the severity of white matter hyperintensities (WMH), which are associated with cognitive impairment and increased risk of progression to Alzheimer’s disease because of the damage they cause to cortical and subcortical networks.Patients and methods: Twenty-nine MCI patients with no or little WMH (MCI-non-WMH) and 22 MCI patients with moderate or severe WMH (MCI-WMH) attended a 24-session CCS program (two sessions per week for a duration of 3 months) focused on executive functions, attention, and processing speed. Cognitive and psychosocial assessments were performed at baseline, postintervention, and 3 months after the intervention.Results: Both groups improved on several cognitive measures after the intervention. However, the MCI-non-WMH group improved on a higher number of cognitive measures than the MCI-WMH group. At postintervention assessment, CCS had a more beneficial effect on the MCI-non-WMH group than on the MCI-WMH group with regard to improving categorical fluency (4.6±6.8 vs 0.4±6.4; effect size=0.37; p=0.002). During the 3-month follow-up assessment, significantly higher score improvements were observed in the MCI-non-WMH group for the paired-associate learning test (6.4±3 vs 4.7±3.5 points; effect size=0.43; p=0.005) as well as categorical fluency (3.8±7.8 vs -0.7±6 points; effect size=0.55; p=0.0003).Conclusions: These findings suggest that WMH severity was related to cognitive improvement induced by a CCS program and highlight the importance of considering WMH in interventional studies on subjects with MCI. Keywords: white matter hyperintensities, mild cognitive impairment, computerized cognitive interventions, brain lesions, Alzheimer’s disease |
| first_indexed | 2024-12-21T02:37:10Z |
| format | Article |
| id | doaj.art-63dbc97851ed4679b03acd3354779d6c |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-12-21T02:37:10Z |
| publishDate | 2018-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-63dbc97851ed4679b03acd3354779d6c2022-12-21T19:18:46ZengDove Medical PressClinical Interventions in Aging1178-19982018-08-01Volume 131543155440204Differential effects of a computerized cognitive stimulation program on older adults with mild cognitive impairment according to the severity of white matter hyperintensitiesDjabelkhir-Jemmi LWu YHBoubaya MMarlats FLewis MVidal JSLenoir HCharlieux BIsabet BRigaud ASLeila Djabelkhir-Jemmi,1,2 Ya-Huei Wu,1,2 Marouane Boubaya,3 Fabienne Marlats,1,2 Manon Lewis,1 Jean-Sébastien Vidal,1,2 Hermine Lenoir,1,2 Benoit Charlieux,1 Baptiste Isabet,1 Anne-Sophie Rigaud1,2 1Department of Clinical Gerontology, Broca Hospital-APHP, Paris, France; 2Research Team EA 4468, Alzheimer’s Disease, Vascular Risk Factors and Diagnostic Markers, Care and Support for Patients and Families, Institute of Psychology of Paris Descartes University, Paris, France; 3Clinical Research Unit, Avicenne Hospital, Bobigny, France Objective: This study aimed to explore whether a computerized cognitive stimulation program (CCS) induced differential effects in older adults with mild cognitive impairment (MCI) according to the severity of white matter hyperintensities (WMH), which are associated with cognitive impairment and increased risk of progression to Alzheimer’s disease because of the damage they cause to cortical and subcortical networks.Patients and methods: Twenty-nine MCI patients with no or little WMH (MCI-non-WMH) and 22 MCI patients with moderate or severe WMH (MCI-WMH) attended a 24-session CCS program (two sessions per week for a duration of 3 months) focused on executive functions, attention, and processing speed. Cognitive and psychosocial assessments were performed at baseline, postintervention, and 3 months after the intervention.Results: Both groups improved on several cognitive measures after the intervention. However, the MCI-non-WMH group improved on a higher number of cognitive measures than the MCI-WMH group. At postintervention assessment, CCS had a more beneficial effect on the MCI-non-WMH group than on the MCI-WMH group with regard to improving categorical fluency (4.6±6.8 vs 0.4±6.4; effect size=0.37; p=0.002). During the 3-month follow-up assessment, significantly higher score improvements were observed in the MCI-non-WMH group for the paired-associate learning test (6.4±3 vs 4.7±3.5 points; effect size=0.43; p=0.005) as well as categorical fluency (3.8±7.8 vs -0.7±6 points; effect size=0.55; p=0.0003).Conclusions: These findings suggest that WMH severity was related to cognitive improvement induced by a CCS program and highlight the importance of considering WMH in interventional studies on subjects with MCI. Keywords: white matter hyperintensities, mild cognitive impairment, computerized cognitive interventions, brain lesions, Alzheimer’s diseasehttps://www.dovepress.com/differential-effects-of-a-computerized-cognitive-stimulation-program-o-peer-reviewed-article-CIAwhite matter hyperintensitiesMild Cognitive Impairmentcomputerized cognitive interventions |
| spellingShingle | Djabelkhir-Jemmi L Wu YH Boubaya M Marlats F Lewis M Vidal JS Lenoir H Charlieux B Isabet B Rigaud AS Differential effects of a computerized cognitive stimulation program on older adults with mild cognitive impairment according to the severity of white matter hyperintensities Clinical Interventions in Aging white matter hyperintensities Mild Cognitive Impairment computerized cognitive interventions |
| title | Differential effects of a computerized cognitive stimulation program on older adults with mild cognitive impairment according to the severity of white matter hyperintensities |
| title_full | Differential effects of a computerized cognitive stimulation program on older adults with mild cognitive impairment according to the severity of white matter hyperintensities |
| title_fullStr | Differential effects of a computerized cognitive stimulation program on older adults with mild cognitive impairment according to the severity of white matter hyperintensities |
| title_full_unstemmed | Differential effects of a computerized cognitive stimulation program on older adults with mild cognitive impairment according to the severity of white matter hyperintensities |
| title_short | Differential effects of a computerized cognitive stimulation program on older adults with mild cognitive impairment according to the severity of white matter hyperintensities |
| title_sort | differential effects of a computerized cognitive stimulation program on older adults with mild cognitive impairment according to the severity of white matter hyperintensities |
| topic | white matter hyperintensities Mild Cognitive Impairment computerized cognitive interventions |
| url | https://www.dovepress.com/differential-effects-of-a-computerized-cognitive-stimulation-program-o-peer-reviewed-article-CIA |
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