Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair
Mesenchymal stem cells (MSCs) are prototypical adult stem cells with the capacity for self-renewal and differentiation with a broad tissue distribution. MSCs not only differentiate into types of cells of mesodermal lineage but also into endodermal and ectodermal lineages such as bone, fat, cartilage...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2013-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2013/132642 |
| _version_ | 1798044242136793088 |
|---|---|
| author | Ming Li Susumu Ikehara |
| author_facet | Ming Li Susumu Ikehara |
| author_sort | Ming Li |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) are prototypical adult stem cells with the capacity for self-renewal and differentiation with a broad tissue distribution. MSCs not only differentiate into types of cells of mesodermal lineage but also into endodermal and ectodermal lineages such as bone, fat, cartilage and cardiomyocytes, endothelial cells, lung epithelial cells, hepatocytes, neurons, and pancreatic islets. MSCs have been identified as an adherent, fibroblast-like population and can be isolated from different adult tissues, including bone marrow (BM), umbilical cord, skeletal muscle, and adipose tissue. MSCs secrete factors, including IL-6, M-CSF, IL-10, HGF, and PGE2, that promote tissue repair, stimulate proliferation and differentiation of endogenous tissue progenitors, and decrease inflammatory and immune reactions. In this paper, we focus on the role of BM-derived MSCs in organ repair. |
| first_indexed | 2024-04-11T23:00:40Z |
| format | Article |
| id | doaj.art-63dbf381615743b1a32799969ca00522 |
| institution | Directory Open Access Journal |
| issn | 1687-966X 1687-9678 |
| language | English |
| last_indexed | 2024-04-11T23:00:40Z |
| publishDate | 2013-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj.art-63dbf381615743b1a32799969ca005222022-12-22T03:58:11ZengHindawi LimitedStem Cells International1687-966X1687-96782013-01-01201310.1155/2013/132642132642Bone-Marrow-Derived Mesenchymal Stem Cells for Organ RepairMing Li0Susumu Ikehara1Department of Stem Cell Disorders, Kansai Medical University, Moriguchi, Osaka 570-8506, JapanDepartment of Stem Cell Disorders, Kansai Medical University, Moriguchi, Osaka 570-8506, JapanMesenchymal stem cells (MSCs) are prototypical adult stem cells with the capacity for self-renewal and differentiation with a broad tissue distribution. MSCs not only differentiate into types of cells of mesodermal lineage but also into endodermal and ectodermal lineages such as bone, fat, cartilage and cardiomyocytes, endothelial cells, lung epithelial cells, hepatocytes, neurons, and pancreatic islets. MSCs have been identified as an adherent, fibroblast-like population and can be isolated from different adult tissues, including bone marrow (BM), umbilical cord, skeletal muscle, and adipose tissue. MSCs secrete factors, including IL-6, M-CSF, IL-10, HGF, and PGE2, that promote tissue repair, stimulate proliferation and differentiation of endogenous tissue progenitors, and decrease inflammatory and immune reactions. In this paper, we focus on the role of BM-derived MSCs in organ repair.http://dx.doi.org/10.1155/2013/132642 |
| spellingShingle | Ming Li Susumu Ikehara Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair Stem Cells International |
| title | Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair |
| title_full | Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair |
| title_fullStr | Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair |
| title_full_unstemmed | Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair |
| title_short | Bone-Marrow-Derived Mesenchymal Stem Cells for Organ Repair |
| title_sort | bone marrow derived mesenchymal stem cells for organ repair |
| url | http://dx.doi.org/10.1155/2013/132642 |
| work_keys_str_mv | AT mingli bonemarrowderivedmesenchymalstemcellsfororganrepair AT susumuikehara bonemarrowderivedmesenchymalstemcellsfororganrepair |