Synthetic studies towards bottromycin
Thio-Ugi reactions are described as an excellent synthetic tool for the synthesis of sterically highly hindered endothiopeptides. S-Methylation and subsequent amidine formation can be carried out in an inter- as well as in an intramolecular fashion. The intramolecular approach allows the synthesis o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2012-10-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.8.189 |
| _version_ | 1818444823447732224 |
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| author | Stefanie Ackermann Hans-Georg Lerchen Dieter Häbich Angelika Ullrich Uli Kazmaier |
| author_facet | Stefanie Ackermann Hans-Georg Lerchen Dieter Häbich Angelika Ullrich Uli Kazmaier |
| author_sort | Stefanie Ackermann |
| collection | DOAJ |
| description | Thio-Ugi reactions are described as an excellent synthetic tool for the synthesis of sterically highly hindered endothiopeptides. S-Methylation and subsequent amidine formation can be carried out in an inter- as well as in an intramolecular fashion. The intramolecular approach allows the synthesis of the bottromycin ring system in a straightforward manner. |
| first_indexed | 2024-12-14T19:22:03Z |
| format | Article |
| id | doaj.art-63dc55d6a55445839d0ecd21f7cf5cd4 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-14T19:22:03Z |
| publishDate | 2012-10-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-63dc55d6a55445839d0ecd21f7cf5cd42022-12-21T22:50:18ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972012-10-01811652165610.3762/bjoc.8.1891860-5397-8-189Synthetic studies towards bottromycinStefanie Ackermann0Hans-Georg Lerchen1Dieter Häbich2Angelika Ullrich3Uli Kazmaier4Institute of Organic Chemistry, Saarland University, P.O. Box 151150, 66041 Saarbrücken, GermanyBayer Pharma Aktiengesellschaft, Aprather Weg 18a, 42113 Wuppertal, GermanyBayer Pharma Aktiengesellschaft, Aprather Weg 18a, 42113 Wuppertal, GermanyInstitute of Organic Chemistry, Saarland University, P.O. Box 151150, 66041 Saarbrücken, GermanyInstitute of Organic Chemistry, Saarland University, P.O. Box 151150, 66041 Saarbrücken, GermanyThio-Ugi reactions are described as an excellent synthetic tool for the synthesis of sterically highly hindered endothiopeptides. S-Methylation and subsequent amidine formation can be carried out in an inter- as well as in an intramolecular fashion. The intramolecular approach allows the synthesis of the bottromycin ring system in a straightforward manner.https://doi.org/10.3762/bjoc.8.189amidinesantibioticsbottromycinpeptidesthiopeptidesUgi reactions |
| spellingShingle | Stefanie Ackermann Hans-Georg Lerchen Dieter Häbich Angelika Ullrich Uli Kazmaier Synthetic studies towards bottromycin Beilstein Journal of Organic Chemistry amidines antibiotics bottromycin peptides thiopeptides Ugi reactions |
| title | Synthetic studies towards bottromycin |
| title_full | Synthetic studies towards bottromycin |
| title_fullStr | Synthetic studies towards bottromycin |
| title_full_unstemmed | Synthetic studies towards bottromycin |
| title_short | Synthetic studies towards bottromycin |
| title_sort | synthetic studies towards bottromycin |
| topic | amidines antibiotics bottromycin peptides thiopeptides Ugi reactions |
| url | https://doi.org/10.3762/bjoc.8.189 |
| work_keys_str_mv | AT stefanieackermann syntheticstudiestowardsbottromycin AT hansgeorglerchen syntheticstudiestowardsbottromycin AT dieterhabich syntheticstudiestowardsbottromycin AT angelikaullrich syntheticstudiestowardsbottromycin AT ulikazmaier syntheticstudiestowardsbottromycin |