Systematic Review and Meta-Analysis of Statin Use and Mortality, Intensive Care Unit Admission and Requirement for Mechanical Ventilation in COVID-19 Patients
There is mounting evidence that statin use is beneficial for COVID-19 outcomes. We performed a systematic review and meta-analysis to evaluate the association between statin use and mortality, intensive care unit (ICU) admission and mechanical ventilation in COVID-19 patients, on studies which provi...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-09-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/18/5454 |
| _version_ | 1797486569808986112 |
|---|---|
| author | Ut-Sam Lao Chak-Fun Law Daniel T. Baptista-Hon Brian Tomlinson |
| author_facet | Ut-Sam Lao Chak-Fun Law Daniel T. Baptista-Hon Brian Tomlinson |
| author_sort | Ut-Sam Lao |
| collection | DOAJ |
| description | There is mounting evidence that statin use is beneficial for COVID-19 outcomes. We performed a systematic review and meta-analysis to evaluate the association between statin use and mortality, intensive care unit (ICU) admission and mechanical ventilation in COVID-19 patients, on studies which provided covariate adjusted effect estimates, or performed propensity score matching. We searched PubMed, Embase, Web of Science and Scopus for studies and extracted odds or hazard ratios for specified outcome measures. Data synthesis was performed using a random-effects inverse variance method. Risk of bias, heterogeneity and publication bias were analyzed using standard methods. Our results show that statin use was associated with significant reductions in mortality (OR = 0.72, 95% CI: 0.67–0.77; HR = 0.74, 95% CI: 0.69, 0.79), ICU admission (OR = 0.94, 95% CI: 0.89–0.99; HR = 0.76, 95% CI: 0.60–0.96) and mechanical ventilation (OR = 0.84, 95% CI: 0.78–0.92; HR = 0.67, 95% CI: 0.47–0.97). Nevertheless, current retrospective studies are based on the antecedent use of statins prior to infection and/or continued use of statin after hospital admission. The results may not apply to the de novo commencement of statin treatment after developing COVID-19 infection. Prospective studies are lacking and necessary. |
| first_indexed | 2024-03-09T23:36:01Z |
| format | Article |
| id | doaj.art-63dd5c5cc3884168a245511fd868b3cc |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T23:36:01Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-63dd5c5cc3884168a245511fd868b3cc2023-11-23T17:01:02ZengMDPI AGJournal of Clinical Medicine2077-03832022-09-011118545410.3390/jcm11185454Systematic Review and Meta-Analysis of Statin Use and Mortality, Intensive Care Unit Admission and Requirement for Mechanical Ventilation in COVID-19 PatientsUt-Sam Lao0Chak-Fun Law1Daniel T. Baptista-Hon2Brian Tomlinson3Center for Biomedicine and Innovations, Faculty of Medicine, Macau University Science and Technology, Taipa, Macau SAR 999078, ChinaCenter for Biomedicine and Innovations, Faculty of Medicine, Macau University Science and Technology, Taipa, Macau SAR 999078, ChinaCenter for Biomedicine and Innovations, Faculty of Medicine, Macau University Science and Technology, Taipa, Macau SAR 999078, ChinaCenter for Biomedicine and Innovations, Faculty of Medicine, Macau University Science and Technology, Taipa, Macau SAR 999078, ChinaThere is mounting evidence that statin use is beneficial for COVID-19 outcomes. We performed a systematic review and meta-analysis to evaluate the association between statin use and mortality, intensive care unit (ICU) admission and mechanical ventilation in COVID-19 patients, on studies which provided covariate adjusted effect estimates, or performed propensity score matching. We searched PubMed, Embase, Web of Science and Scopus for studies and extracted odds or hazard ratios for specified outcome measures. Data synthesis was performed using a random-effects inverse variance method. Risk of bias, heterogeneity and publication bias were analyzed using standard methods. Our results show that statin use was associated with significant reductions in mortality (OR = 0.72, 95% CI: 0.67–0.77; HR = 0.74, 95% CI: 0.69, 0.79), ICU admission (OR = 0.94, 95% CI: 0.89–0.99; HR = 0.76, 95% CI: 0.60–0.96) and mechanical ventilation (OR = 0.84, 95% CI: 0.78–0.92; HR = 0.67, 95% CI: 0.47–0.97). Nevertheless, current retrospective studies are based on the antecedent use of statins prior to infection and/or continued use of statin after hospital admission. The results may not apply to the de novo commencement of statin treatment after developing COVID-19 infection. Prospective studies are lacking and necessary.https://www.mdpi.com/2077-0383/11/18/5454COVID-19intensive care unitmechanical ventilationmeta-analysismortalitystatin |
| spellingShingle | Ut-Sam Lao Chak-Fun Law Daniel T. Baptista-Hon Brian Tomlinson Systematic Review and Meta-Analysis of Statin Use and Mortality, Intensive Care Unit Admission and Requirement for Mechanical Ventilation in COVID-19 Patients Journal of Clinical Medicine COVID-19 intensive care unit mechanical ventilation meta-analysis mortality statin |
| title | Systematic Review and Meta-Analysis of Statin Use and Mortality, Intensive Care Unit Admission and Requirement for Mechanical Ventilation in COVID-19 Patients |
| title_full | Systematic Review and Meta-Analysis of Statin Use and Mortality, Intensive Care Unit Admission and Requirement for Mechanical Ventilation in COVID-19 Patients |
| title_fullStr | Systematic Review and Meta-Analysis of Statin Use and Mortality, Intensive Care Unit Admission and Requirement for Mechanical Ventilation in COVID-19 Patients |
| title_full_unstemmed | Systematic Review and Meta-Analysis of Statin Use and Mortality, Intensive Care Unit Admission and Requirement for Mechanical Ventilation in COVID-19 Patients |
| title_short | Systematic Review and Meta-Analysis of Statin Use and Mortality, Intensive Care Unit Admission and Requirement for Mechanical Ventilation in COVID-19 Patients |
| title_sort | systematic review and meta analysis of statin use and mortality intensive care unit admission and requirement for mechanical ventilation in covid 19 patients |
| topic | COVID-19 intensive care unit mechanical ventilation meta-analysis mortality statin |
| url | https://www.mdpi.com/2077-0383/11/18/5454 |
| work_keys_str_mv | AT utsamlao systematicreviewandmetaanalysisofstatinuseandmortalityintensivecareunitadmissionandrequirementformechanicalventilationincovid19patients AT chakfunlaw systematicreviewandmetaanalysisofstatinuseandmortalityintensivecareunitadmissionandrequirementformechanicalventilationincovid19patients AT danieltbaptistahon systematicreviewandmetaanalysisofstatinuseandmortalityintensivecareunitadmissionandrequirementformechanicalventilationincovid19patients AT briantomlinson systematicreviewandmetaanalysisofstatinuseandmortalityintensivecareunitadmissionandrequirementformechanicalventilationincovid19patients |