Bioengineering lantibiotics for therapeutic success

Several examples of highly modified antimicrobial peptides have been described. While many such peptides are non-ribosomally synthesized, ribosomally synthesised equivalents are being discovered with increased frequency. Of the latter group, the lantibiotics continue to attract most attention. In th...

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Main Authors: Des eField, Paul David Cotter, Colin eHill, R Paul Ross
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Microbiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01363/full
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author Des eField
Paul David Cotter
Paul David Cotter
Colin eHill
Colin eHill
R Paul Ross
R Paul Ross
author_facet Des eField
Paul David Cotter
Paul David Cotter
Colin eHill
Colin eHill
R Paul Ross
R Paul Ross
author_sort Des eField
collection DOAJ
description Several examples of highly modified antimicrobial peptides have been described. While many such peptides are non-ribosomally synthesized, ribosomally synthesised equivalents are being discovered with increased frequency. Of the latter group, the lantibiotics continue to attract most attention. In the present review, we discuss the implementation of in vivo and in vitro engineering systems to alter, and even enhance, the antimicrobial activity, antibacterial spectrum and physico-chemical properties, including heat stability, solubility, diffusion and protease resistance, of these compounds. Additionally, we discuss the potential applications of these lantibiotics for use as therapeutics.
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spelling doaj.art-63de050de7c044249dbdbf4d73071c792022-12-21T18:32:33ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2015-11-01610.3389/fmicb.2015.01363170560Bioengineering lantibiotics for therapeutic successDes eField0Paul David Cotter1Paul David Cotter2Colin eHill3Colin eHill4R Paul Ross5R Paul Ross6School of MicrobiologyTeagasc Food Research CentreAPC Microbiome InstituteSchool of MicrobiologyAPC Microbiome InstituteTeagasc Food Research CentreAPC Microbiome InstituteSeveral examples of highly modified antimicrobial peptides have been described. While many such peptides are non-ribosomally synthesized, ribosomally synthesised equivalents are being discovered with increased frequency. Of the latter group, the lantibiotics continue to attract most attention. In the present review, we discuss the implementation of in vivo and in vitro engineering systems to alter, and even enhance, the antimicrobial activity, antibacterial spectrum and physico-chemical properties, including heat stability, solubility, diffusion and protease resistance, of these compounds. Additionally, we discuss the potential applications of these lantibiotics for use as therapeutics.http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01363/fullBacteriocinsBioengineeringMutagenesisNisinantimicrobial peptideslantibiotics
spellingShingle Des eField
Paul David Cotter
Paul David Cotter
Colin eHill
Colin eHill
R Paul Ross
R Paul Ross
Bioengineering lantibiotics for therapeutic success
Frontiers in Microbiology
Bacteriocins
Bioengineering
Mutagenesis
Nisin
antimicrobial peptides
lantibiotics
title Bioengineering lantibiotics for therapeutic success
title_full Bioengineering lantibiotics for therapeutic success
title_fullStr Bioengineering lantibiotics for therapeutic success
title_full_unstemmed Bioengineering lantibiotics for therapeutic success
title_short Bioengineering lantibiotics for therapeutic success
title_sort bioengineering lantibiotics for therapeutic success
topic Bacteriocins
Bioengineering
Mutagenesis
Nisin
antimicrobial peptides
lantibiotics
url http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01363/full
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AT colinehill bioengineeringlantibioticsfortherapeuticsuccess
AT rpaulross bioengineeringlantibioticsfortherapeuticsuccess
AT rpaulross bioengineeringlantibioticsfortherapeuticsuccess