Bioengineering lantibiotics for therapeutic success
Several examples of highly modified antimicrobial peptides have been described. While many such peptides are non-ribosomally synthesized, ribosomally synthesised equivalents are being discovered with increased frequency. Of the latter group, the lantibiotics continue to attract most attention. In th...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2015-11-01
|
Series: | Frontiers in Microbiology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01363/full |
_version_ | 1819128487189938176 |
---|---|
author | Des eField Paul David Cotter Paul David Cotter Colin eHill Colin eHill R Paul Ross R Paul Ross |
author_facet | Des eField Paul David Cotter Paul David Cotter Colin eHill Colin eHill R Paul Ross R Paul Ross |
author_sort | Des eField |
collection | DOAJ |
description | Several examples of highly modified antimicrobial peptides have been described. While many such peptides are non-ribosomally synthesized, ribosomally synthesised equivalents are being discovered with increased frequency. Of the latter group, the lantibiotics continue to attract most attention. In the present review, we discuss the implementation of in vivo and in vitro engineering systems to alter, and even enhance, the antimicrobial activity, antibacterial spectrum and physico-chemical properties, including heat stability, solubility, diffusion and protease resistance, of these compounds. Additionally, we discuss the potential applications of these lantibiotics for use as therapeutics. |
first_indexed | 2024-12-22T08:28:36Z |
format | Article |
id | doaj.art-63de050de7c044249dbdbf4d73071c79 |
institution | Directory Open Access Journal |
issn | 1664-302X |
language | English |
last_indexed | 2024-12-22T08:28:36Z |
publishDate | 2015-11-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Microbiology |
spelling | doaj.art-63de050de7c044249dbdbf4d73071c792022-12-21T18:32:33ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2015-11-01610.3389/fmicb.2015.01363170560Bioengineering lantibiotics for therapeutic successDes eField0Paul David Cotter1Paul David Cotter2Colin eHill3Colin eHill4R Paul Ross5R Paul Ross6School of MicrobiologyTeagasc Food Research CentreAPC Microbiome InstituteSchool of MicrobiologyAPC Microbiome InstituteTeagasc Food Research CentreAPC Microbiome InstituteSeveral examples of highly modified antimicrobial peptides have been described. While many such peptides are non-ribosomally synthesized, ribosomally synthesised equivalents are being discovered with increased frequency. Of the latter group, the lantibiotics continue to attract most attention. In the present review, we discuss the implementation of in vivo and in vitro engineering systems to alter, and even enhance, the antimicrobial activity, antibacterial spectrum and physico-chemical properties, including heat stability, solubility, diffusion and protease resistance, of these compounds. Additionally, we discuss the potential applications of these lantibiotics for use as therapeutics.http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01363/fullBacteriocinsBioengineeringMutagenesisNisinantimicrobial peptideslantibiotics |
spellingShingle | Des eField Paul David Cotter Paul David Cotter Colin eHill Colin eHill R Paul Ross R Paul Ross Bioengineering lantibiotics for therapeutic success Frontiers in Microbiology Bacteriocins Bioengineering Mutagenesis Nisin antimicrobial peptides lantibiotics |
title | Bioengineering lantibiotics for therapeutic success |
title_full | Bioengineering lantibiotics for therapeutic success |
title_fullStr | Bioengineering lantibiotics for therapeutic success |
title_full_unstemmed | Bioengineering lantibiotics for therapeutic success |
title_short | Bioengineering lantibiotics for therapeutic success |
title_sort | bioengineering lantibiotics for therapeutic success |
topic | Bacteriocins Bioengineering Mutagenesis Nisin antimicrobial peptides lantibiotics |
url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01363/full |
work_keys_str_mv | AT desefield bioengineeringlantibioticsfortherapeuticsuccess AT pauldavidcotter bioengineeringlantibioticsfortherapeuticsuccess AT pauldavidcotter bioengineeringlantibioticsfortherapeuticsuccess AT colinehill bioengineeringlantibioticsfortherapeuticsuccess AT colinehill bioengineeringlantibioticsfortherapeuticsuccess AT rpaulross bioengineeringlantibioticsfortherapeuticsuccess AT rpaulross bioengineeringlantibioticsfortherapeuticsuccess |