Downregulation of miR-760 Causes Human Intervertebral Disc Degeneration by Targeting the MyD88/Nuclear Factor-Kappa B Signaling Pathway

Downregulation of miR-760 Causes Human Intervertebral Disc Degeneration by Targeting the MyD88/Nuclear Factor-Kappa B Signaling Pathway

Dysregulation of microRNAs (miRNAs) plays a critical role in the development of intervertebral disc degeneration (IDD). In this study, we present evidence from in vitro and in vivo research to elucidate the mechanism underlying the role of miR-760 in IDD. miRNA microarray and quantitative reverse tr...

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Bibliographic Details
Main Authors: Xueliang Cui, Yanan Li, Junping Bao, Kun Wang, Xiaotao Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
miR-760
intervertebral disc degeneration
MyD88
nucleus pulposus cells
NF-κB signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.813070/full

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