The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes
Cancer: A regulator of cell cycle gene expression An RNA-binding protein contributes to cancer by boosting the protein-making potential of various genes involved in the cell cycle and cell division. Researchers in Taiwan led by Liang-Yi Hung from the National Cheng Kung University in Tainan, Taiwan,...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-06-01
|
| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-018-0101-6 |
| _version_ | 1829520006597050368 |
|---|---|
| author | Yu-Chu Wang Kung-Chao Chang Bo-Wen Lin Jenq-Chang Lee Chien-Hsien Lai Li-Jyuan Lin Yun Yen Chang-Shen Lin Shiang-Jie Yang Peng-Chan Lin Chung-Ta Lee Liang-Yi Hung |
| author_facet | Yu-Chu Wang Kung-Chao Chang Bo-Wen Lin Jenq-Chang Lee Chien-Hsien Lai Li-Jyuan Lin Yun Yen Chang-Shen Lin Shiang-Jie Yang Peng-Chan Lin Chung-Ta Lee Liang-Yi Hung |
| author_sort | Yu-Chu Wang |
| collection | DOAJ |
| description | Cancer: A regulator of cell cycle gene expression An RNA-binding protein contributes to cancer by boosting the protein-making potential of various genes involved in the cell cycle and cell division. Researchers in Taiwan led by Liang-Yi Hung from the National Cheng Kung University in Tainan, Taiwan, previously showed that a cancer-causing protein implicated in tumors of the colon and elsewhere gets induced by both an RNA-binding protein called hnRNP Q1 and a growth factor called EGF. Now, they have demonstrated that these two molecules work in concert to boost the efficiency by which the RNA encoding the cancer-causing protein gets translated into the protein. They also showed that hnRNP Q1 serves a similar RNA-modulating function for several genes involved in spindle checkpoint during cell division. Together, the findings point to hnRNP Q1 as a potential target for future anti-cancer drugs. |
| first_indexed | 2024-12-16T14:49:46Z |
| format | Article |
| id | doaj.art-63e2601a32054929a16cc5bee24072f1 |
| institution | Directory Open Access Journal |
| issn | 1226-3613 2092-6413 |
| language | English |
| last_indexed | 2024-12-16T14:49:46Z |
| publishDate | 2018-06-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-63e2601a32054929a16cc5bee24072f12022-12-21T22:27:38ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132018-06-0150611410.1038/s12276-018-0101-6The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genesYu-Chu Wang0Kung-Chao Chang1Bo-Wen Lin2Jenq-Chang Lee3Chien-Hsien Lai4Li-Jyuan Lin5Yun Yen6Chang-Shen Lin7Shiang-Jie Yang8Peng-Chan Lin9Chung-Ta Lee10Liang-Yi Hung11Department of Biotechnology and Bioindustry Sciences, National Cheng-Kung UniversityDepartment of Pathology, National Cheng Kung University HospitalDepartment of Surgery, National Cheng Kung University HospitalDepartment of Surgery, National Cheng Kung University HospitalDepartment of Biotechnology and Bioindustry Sciences, National Cheng-Kung UniversityInstitute of Bioinformatics and Biosignal Transduction, College of Bioscience and Biotechnology, National Cheng-Kung UniversityPh.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical UniversityGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical UniversityInstitute of Basic Medical Sciences, National Cheng Kung UniversityDepartment of Internal Medicine, College of Medicine, , National Cheng Kung University HospitalDepartment of Pathology, National Cheng Kung University HospitalDepartment of Biotechnology and Bioindustry Sciences, National Cheng-Kung UniversityCancer: A regulator of cell cycle gene expression An RNA-binding protein contributes to cancer by boosting the protein-making potential of various genes involved in the cell cycle and cell division. Researchers in Taiwan led by Liang-Yi Hung from the National Cheng Kung University in Tainan, Taiwan, previously showed that a cancer-causing protein implicated in tumors of the colon and elsewhere gets induced by both an RNA-binding protein called hnRNP Q1 and a growth factor called EGF. Now, they have demonstrated that these two molecules work in concert to boost the efficiency by which the RNA encoding the cancer-causing protein gets translated into the protein. They also showed that hnRNP Q1 serves a similar RNA-modulating function for several genes involved in spindle checkpoint during cell division. Together, the findings point to hnRNP Q1 as a potential target for future anti-cancer drugs.https://doi.org/10.1038/s12276-018-0101-6 |
| spellingShingle | Yu-Chu Wang Kung-Chao Chang Bo-Wen Lin Jenq-Chang Lee Chien-Hsien Lai Li-Jyuan Lin Yun Yen Chang-Shen Lin Shiang-Jie Yang Peng-Chan Lin Chung-Ta Lee Liang-Yi Hung The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes Experimental and Molecular Medicine |
| title | The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes |
| title_full | The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes |
| title_fullStr | The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes |
| title_full_unstemmed | The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes |
| title_short | The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes |
| title_sort | egf hnrnp q1 axis is involved in tumorigenesis via the regulation of cell cycle related genes |
| url | https://doi.org/10.1038/s12276-018-0101-6 |
| work_keys_str_mv | AT yuchuwang theegfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT kungchaochang theegfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT bowenlin theegfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT jenqchanglee theegfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT chienhsienlai theegfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT lijyuanlin theegfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT yunyen theegfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT changshenlin theegfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT shiangjieyang theegfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT pengchanlin theegfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT chungtalee theegfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT liangyihung theegfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT yuchuwang egfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT kungchaochang egfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT bowenlin egfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT jenqchanglee egfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT chienhsienlai egfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT lijyuanlin egfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT yunyen egfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT changshenlin egfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT shiangjieyang egfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT pengchanlin egfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT chungtalee egfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes AT liangyihung egfhnrnpq1axisisinvolvedintumorigenesisviatheregulationofcellcyclerelatedgenes |