New Insights into Potential Prevention and Management Options for Chemotherapy-Induced Peripheral Neuropathy
Objective: Neurological complications such as chemotherapy-induced peripheral neuropathy (CIPN) and neuropathic pain are frequent side effects of neurotoxic chemotherapy agents. An increasing survival rate and frequent administration of adjuvant chemotherapy treatments involving neurotoxic agents ma...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-01-01
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| Series: | Asia-Pacific Journal of Oncology Nursing |
| Subjects: | |
| Online Access: | http://www.apjon.org/article.asp?issn=2347-5625;year=2016;volume=3;issue=1;spage=73;epage=85;aulast=Schloss |
| _version_ | 1797713011160383488 |
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| author | Janet Schloss Maree Colosimo Luis Vitetta |
| author_facet | Janet Schloss Maree Colosimo Luis Vitetta |
| author_sort | Janet Schloss |
| collection | DOAJ |
| description | Objective: Neurological complications such as chemotherapy-induced peripheral neuropathy (CIPN) and neuropathic pain are frequent side effects of neurotoxic chemotherapy agents. An increasing survival rate and frequent administration of adjuvant chemotherapy treatments involving neurotoxic agents makes it imperative that accurate diagnosis, prevention, and treatment of these neurological complications be implemented. Methods: A consideration was undertaken of the current options regarding protective and treatment interventions for patients undergoing chemotherapy with neurotoxic chemotherapy agent or experience with CIPN. Current knowledge on the mechanism of action has also been identified. The following databases PubMed, the Cochrane Library, Science Direct, Scopus, EMBASE, MEDLINE, CINAHL, CNKI, and Google Scholar were searched for relevant article retrieval. Results: A range of pharmaceutical, nutraceutical, and herbal medicine treatments were identified that either showed efficacy or had some evidence of efficacy. Duloxetine was the most effective pharmaceutical agent for the treatment of CIPN. Vitamin E demonstrated potential for the prevention of cisplatin-IPN. Intravenous glutathione for oxaliplatin, Vitamin B6 for both oxaliplatin and cisplatin, and omega 3 fatty acids for paclitaxel have shown protection for CIPN. Acetyl-L-carnitine may provide some relief as a treatment option. Acupuncture may be of benefit for some patients and Gosha-jinki-gan may be of benefit for protection from adverse effects of oxaliplatin induced peripheral neuropathy. Conclusions: Clinicians and researchers acknowledge that there are numerous challenges involved in understanding, preventing, and treating peripheral neuropathy caused by chemotherapeutic agents. New insights into mechanisms of action from chemotherapy agents may facilitate the development of novel preventative and treatment options, thereby enabling medical staff to better support patients by reducing this debilitating side effect. |
| first_indexed | 2024-03-12T07:30:13Z |
| format | Article |
| id | doaj.art-63e2ad4cea44460abb19717b69b1b0e1 |
| institution | Directory Open Access Journal |
| issn | 2347-5625 2349-6673 |
| language | English |
| last_indexed | 2024-03-12T07:30:13Z |
| publishDate | 2016-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asia-Pacific Journal of Oncology Nursing |
| spelling | doaj.art-63e2ad4cea44460abb19717b69b1b0e12023-09-02T21:52:50ZengElsevierAsia-Pacific Journal of Oncology Nursing2347-56252349-66732016-01-0131738510.4103/2347-5625.170977New Insights into Potential Prevention and Management Options for Chemotherapy-Induced Peripheral NeuropathyJanet SchlossMaree ColosimoLuis VitettaObjective: Neurological complications such as chemotherapy-induced peripheral neuropathy (CIPN) and neuropathic pain are frequent side effects of neurotoxic chemotherapy agents. An increasing survival rate and frequent administration of adjuvant chemotherapy treatments involving neurotoxic agents makes it imperative that accurate diagnosis, prevention, and treatment of these neurological complications be implemented. Methods: A consideration was undertaken of the current options regarding protective and treatment interventions for patients undergoing chemotherapy with neurotoxic chemotherapy agent or experience with CIPN. Current knowledge on the mechanism of action has also been identified. The following databases PubMed, the Cochrane Library, Science Direct, Scopus, EMBASE, MEDLINE, CINAHL, CNKI, and Google Scholar were searched for relevant article retrieval. Results: A range of pharmaceutical, nutraceutical, and herbal medicine treatments were identified that either showed efficacy or had some evidence of efficacy. Duloxetine was the most effective pharmaceutical agent for the treatment of CIPN. Vitamin E demonstrated potential for the prevention of cisplatin-IPN. Intravenous glutathione for oxaliplatin, Vitamin B6 for both oxaliplatin and cisplatin, and omega 3 fatty acids for paclitaxel have shown protection for CIPN. Acetyl-L-carnitine may provide some relief as a treatment option. Acupuncture may be of benefit for some patients and Gosha-jinki-gan may be of benefit for protection from adverse effects of oxaliplatin induced peripheral neuropathy. Conclusions: Clinicians and researchers acknowledge that there are numerous challenges involved in understanding, preventing, and treating peripheral neuropathy caused by chemotherapeutic agents. New insights into mechanisms of action from chemotherapy agents may facilitate the development of novel preventative and treatment options, thereby enabling medical staff to better support patients by reducing this debilitating side effect.http://www.apjon.org/article.asp?issn=2347-5625;year=2016;volume=3;issue=1;spage=73;epage=85;aulast=SchlossBortezomibchemotherapy-induced peripheral neuropathycisplatinmanagementneuropathic painpreventiontaxanetreatmentvincristine |
| spellingShingle | Janet Schloss Maree Colosimo Luis Vitetta New Insights into Potential Prevention and Management Options for Chemotherapy-Induced Peripheral Neuropathy Asia-Pacific Journal of Oncology Nursing Bortezomib chemotherapy-induced peripheral neuropathy cisplatin management neuropathic pain prevention taxane treatment vincristine |
| title | New Insights into Potential Prevention and Management Options for Chemotherapy-Induced Peripheral Neuropathy |
| title_full | New Insights into Potential Prevention and Management Options for Chemotherapy-Induced Peripheral Neuropathy |
| title_fullStr | New Insights into Potential Prevention and Management Options for Chemotherapy-Induced Peripheral Neuropathy |
| title_full_unstemmed | New Insights into Potential Prevention and Management Options for Chemotherapy-Induced Peripheral Neuropathy |
| title_short | New Insights into Potential Prevention and Management Options for Chemotherapy-Induced Peripheral Neuropathy |
| title_sort | new insights into potential prevention and management options for chemotherapy induced peripheral neuropathy |
| topic | Bortezomib chemotherapy-induced peripheral neuropathy cisplatin management neuropathic pain prevention taxane treatment vincristine |
| url | http://www.apjon.org/article.asp?issn=2347-5625;year=2016;volume=3;issue=1;spage=73;epage=85;aulast=Schloss |
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