Efficacy of single intravitreal injection of Ranibizumab for diabetic macular edema
AIM: To observe the efficacy of single time intravitreal injection of ranibizumab(IVR)in patients with diabetic macular edema(DME).<p>METHODS: Twenty-nine cases of DME patients who complied with diagnostic criteria for clinically significant macular edema were enrolled in this retrospective st...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2017-03-01
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| Series: | Guoji Yanke Zazhi |
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| Online Access: | http://ies.ijo.cn/cn_publish/2017/3/201703029.pdf |
| _version_ | 1818135973570019328 |
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| author | Yu-Dong Fu Xu-Xia Meng Da-Bo Wang Zhao-Dong Du Hai-Tao Wang |
| author_facet | Yu-Dong Fu Xu-Xia Meng Da-Bo Wang Zhao-Dong Du Hai-Tao Wang |
| author_sort | Yu-Dong Fu |
| collection | DOAJ |
| description | AIM: To observe the efficacy of single time intravitreal injection of ranibizumab(IVR)in patients with diabetic macular edema(DME).<p>METHODS: Twenty-nine cases of DME patients who complied with diagnostic criteria for clinically significant macular edema were enrolled in this retrospective study. All the patients receive single dose IVR(0.05mL, 10mg/mL), and no other eye treatments were performed before this operation. All data were recorded before and after injection of 4, 8, and 16wk. Best corrected visual acuity(BCVA), central foveal thickness(CFT), the integrity of the foveal photoreceptor layer on optical coherence tomography were analyzed. The data of photoreceptor integrity and photoreceptor defect group also were recorded and analyzed.<p>RESULTS: BCVA was significantly improved at 4 and 8wk after IVR(<i>P</i>=0.009,0.003), macular edema was relieved, and CFT was significantly lower in the same time(<i>P</i><0.01,<i>P</i>=0.001). But the drug action was weakened in 16wk, BCVA was poorer than that in 4 and 8wk(<i>P</i>=0.043,0.019), macular edema recurred CFT increased(<i>P</i><0.01,<i>P</i>=0.005). BCVA and CFT value were not statistically significant different between 4 and 8wk(<i>P</i>=0.074,0.420). There was no significant change in BCVA before and after surgery in photoreceptor complete group(<i>P</i>=0.076), but CFT was lower obviously(<i>P</i>=0.001). BCVA and CFT value were better in photoreceptor defect group after IVR in 4wk(<i>P</i><0.01,<i>P</i><0.01). There was significant correlation between visual acuity and photoreceptor integrity before and after treatment in 4wk(<i>P</i>=0.015, 0.024).<p> CONCLUSION: Patients with DME treated with ranibizumab obtained great improvements in vision and macular edema in the short term. Macular photoreceptor integrity was closely related to the vision. IVR may also repair the macular photoreceptor damage. |
| first_indexed | 2024-12-11T09:33:01Z |
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| id | doaj.art-63e319042ff64d15811cd2193e687f8a |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-11T09:33:01Z |
| publishDate | 2017-03-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
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| series | Guoji Yanke Zazhi |
| spelling | doaj.art-63e319042ff64d15811cd2193e687f8a2022-12-22T01:12:57ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232017-03-0117350450710.3980/j.issn.1672-5123.2017.3.29Efficacy of single intravitreal injection of Ranibizumab for diabetic macular edemaYu-Dong Fu0Xu-Xia Meng1Da-Bo Wang2Zhao-Dong Du3Hai-Tao Wang4Department of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, ChinaDepartment of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, ChinaDepartment of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, ChinaDepartment of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, ChinaDepartment of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, ChinaAIM: To observe the efficacy of single time intravitreal injection of ranibizumab(IVR)in patients with diabetic macular edema(DME).<p>METHODS: Twenty-nine cases of DME patients who complied with diagnostic criteria for clinically significant macular edema were enrolled in this retrospective study. All the patients receive single dose IVR(0.05mL, 10mg/mL), and no other eye treatments were performed before this operation. All data were recorded before and after injection of 4, 8, and 16wk. Best corrected visual acuity(BCVA), central foveal thickness(CFT), the integrity of the foveal photoreceptor layer on optical coherence tomography were analyzed. The data of photoreceptor integrity and photoreceptor defect group also were recorded and analyzed.<p>RESULTS: BCVA was significantly improved at 4 and 8wk after IVR(<i>P</i>=0.009,0.003), macular edema was relieved, and CFT was significantly lower in the same time(<i>P</i><0.01,<i>P</i>=0.001). But the drug action was weakened in 16wk, BCVA was poorer than that in 4 and 8wk(<i>P</i>=0.043,0.019), macular edema recurred CFT increased(<i>P</i><0.01,<i>P</i>=0.005). BCVA and CFT value were not statistically significant different between 4 and 8wk(<i>P</i>=0.074,0.420). There was no significant change in BCVA before and after surgery in photoreceptor complete group(<i>P</i>=0.076), but CFT was lower obviously(<i>P</i>=0.001). BCVA and CFT value were better in photoreceptor defect group after IVR in 4wk(<i>P</i><0.01,<i>P</i><0.01). There was significant correlation between visual acuity and photoreceptor integrity before and after treatment in 4wk(<i>P</i>=0.015, 0.024).<p> CONCLUSION: Patients with DME treated with ranibizumab obtained great improvements in vision and macular edema in the short term. Macular photoreceptor integrity was closely related to the vision. IVR may also repair the macular photoreceptor damage.http://ies.ijo.cn/cn_publish/2017/3/201703029.pdfdiabetic macular edemaranibizumaboptical coherence tomographyphotoreceptorphotoreceptor |
| spellingShingle | Yu-Dong Fu Xu-Xia Meng Da-Bo Wang Zhao-Dong Du Hai-Tao Wang Efficacy of single intravitreal injection of Ranibizumab for diabetic macular edema Guoji Yanke Zazhi diabetic macular edema ranibizumab optical coherence tomography photoreceptor photoreceptor |
| title | Efficacy of single intravitreal injection of Ranibizumab for diabetic macular edema |
| title_full | Efficacy of single intravitreal injection of Ranibizumab for diabetic macular edema |
| title_fullStr | Efficacy of single intravitreal injection of Ranibizumab for diabetic macular edema |
| title_full_unstemmed | Efficacy of single intravitreal injection of Ranibizumab for diabetic macular edema |
| title_short | Efficacy of single intravitreal injection of Ranibizumab for diabetic macular edema |
| title_sort | efficacy of single intravitreal injection of ranibizumab for diabetic macular edema |
| topic | diabetic macular edema ranibizumab optical coherence tomography photoreceptor photoreceptor |
| url | http://ies.ijo.cn/cn_publish/2017/3/201703029.pdf |
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