Green Propolis Compounds (Baccharin and p-Coumaric Acid) Show Beneficial Effects in Mice for Melanoma Induced by B16f10
<b>Background:</b> Cutaneous melanoma is the most aggressive form of skin cancer, with the worst prognosis, and it affects a younger population than most cancers. The high metastatic index, in more advanced stages, and the high aggressiveness decrease the effectiveness of currently used...
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MDPI AG
2021-04-01
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| Series: | Medicines |
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| Online Access: | https://www.mdpi.com/2305-6320/8/5/20 |
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| author | Gabriel H. Gastaldello Ana Caroline V. Cazeloto Juliana C. Ferreira Débora Munhoz Rodrigues Jairo Kennup Bastos Vanessa L. Campo Karina F. Zoccal Cristiane Tefé-Silva |
| author_facet | Gabriel H. Gastaldello Ana Caroline V. Cazeloto Juliana C. Ferreira Débora Munhoz Rodrigues Jairo Kennup Bastos Vanessa L. Campo Karina F. Zoccal Cristiane Tefé-Silva |
| author_sort | Gabriel H. Gastaldello |
| collection | DOAJ |
| description | <b>Background:</b> Cutaneous melanoma is the most aggressive form of skin cancer, with the worst prognosis, and it affects a younger population than most cancers. The high metastatic index, in more advanced stages, and the high aggressiveness decrease the effectiveness of currently used therapies, such as surgical removal, radiotherapy, cryotherapy, and chemotherapy, used alone or in combination. Based on these disadvantages, research focused on alternative medicine offers great potential for therapeutic innovation. Medicinal plants represent a remarkable source of compounds for the treatment of various diseases. <b>Methods:</b> In this study, we investigated the tumoral behavior of melanoma under treatment with the compounds baccharin and p-coumaric acid, extracted from green propolis, in mice inoculated with B16F10 cells for 26 days. <b>Results:</b> A significant modulation in the number of inflammatory cells recruited to the tumor region and blood in the groups treated with the compounds was observed. In addition, a significant reduction in the amount of blood vessels and mitosis in the neoplastic area was noticed. <b>Conclusions:</b> Through our research, we confirmed that baccharin and coumaric acid, isolated substances from Brazilian green propolis, have a promising anticarcinogenic potential to be explored for the development of new antitumor agents, adhering to the trend of drugs with greater tolerance and biological effectiveness. |
| first_indexed | 2024-03-10T11:48:09Z |
| format | Article |
| id | doaj.art-63e349198ed947d1a8876f1dd0829e3d |
| institution | Directory Open Access Journal |
| issn | 2305-6320 |
| language | English |
| last_indexed | 2024-03-10T11:48:09Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicines |
| spelling | doaj.art-63e349198ed947d1a8876f1dd0829e3d2023-11-21T17:53:30ZengMDPI AGMedicines2305-63202021-04-01852010.3390/medicines8050020Green Propolis Compounds (Baccharin and p-Coumaric Acid) Show Beneficial Effects in Mice for Melanoma Induced by B16f10Gabriel H. Gastaldello0Ana Caroline V. Cazeloto1Juliana C. Ferreira2Débora Munhoz Rodrigues3Jairo Kennup Bastos4Vanessa L. Campo5Karina F. Zoccal6Cristiane Tefé-Silva7Centro Universitário Barão de Mauá (CBM), Rua Ramos de Azevedo, n 423, Ribeirão Preto, SP 14090-180, BrazilCentro Universitário Barão de Mauá (CBM), Rua Ramos de Azevedo, n 423, Ribeirão Preto, SP 14090-180, BrazilCentro Universitário Barão de Mauá (CBM), Rua Ramos de Azevedo, n 423, Ribeirão Preto, SP 14090-180, BrazilDepartamento de Ciências Farmacêuticas. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café, s/n, Ribeirão Preto, SP 14040-903, BrazilDepartamento de Ciências Farmacêuticas. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café, s/n, Ribeirão Preto, SP 14040-903, BrazilCentro Universitário Barão de Mauá (CBM), Rua Ramos de Azevedo, n 423, Ribeirão Preto, SP 14090-180, BrazilCentro Universitário Barão de Mauá (CBM), Rua Ramos de Azevedo, n 423, Ribeirão Preto, SP 14090-180, BrazilCentro Universitário Barão de Mauá (CBM), Rua Ramos de Azevedo, n 423, Ribeirão Preto, SP 14090-180, Brazil<b>Background:</b> Cutaneous melanoma is the most aggressive form of skin cancer, with the worst prognosis, and it affects a younger population than most cancers. The high metastatic index, in more advanced stages, and the high aggressiveness decrease the effectiveness of currently used therapies, such as surgical removal, radiotherapy, cryotherapy, and chemotherapy, used alone or in combination. Based on these disadvantages, research focused on alternative medicine offers great potential for therapeutic innovation. Medicinal plants represent a remarkable source of compounds for the treatment of various diseases. <b>Methods:</b> In this study, we investigated the tumoral behavior of melanoma under treatment with the compounds baccharin and p-coumaric acid, extracted from green propolis, in mice inoculated with B16F10 cells for 26 days. <b>Results:</b> A significant modulation in the number of inflammatory cells recruited to the tumor region and blood in the groups treated with the compounds was observed. In addition, a significant reduction in the amount of blood vessels and mitosis in the neoplastic area was noticed. <b>Conclusions:</b> Through our research, we confirmed that baccharin and coumaric acid, isolated substances from Brazilian green propolis, have a promising anticarcinogenic potential to be explored for the development of new antitumor agents, adhering to the trend of drugs with greater tolerance and biological effectiveness.https://www.mdpi.com/2305-6320/8/5/20melanomaskin cancerbaccharincoumaric acidcancer therapy |
| spellingShingle | Gabriel H. Gastaldello Ana Caroline V. Cazeloto Juliana C. Ferreira Débora Munhoz Rodrigues Jairo Kennup Bastos Vanessa L. Campo Karina F. Zoccal Cristiane Tefé-Silva Green Propolis Compounds (Baccharin and p-Coumaric Acid) Show Beneficial Effects in Mice for Melanoma Induced by B16f10 Medicines melanoma skin cancer baccharin coumaric acid cancer therapy |
| title | Green Propolis Compounds (Baccharin and p-Coumaric Acid) Show Beneficial Effects in Mice for Melanoma Induced by B16f10 |
| title_full | Green Propolis Compounds (Baccharin and p-Coumaric Acid) Show Beneficial Effects in Mice for Melanoma Induced by B16f10 |
| title_fullStr | Green Propolis Compounds (Baccharin and p-Coumaric Acid) Show Beneficial Effects in Mice for Melanoma Induced by B16f10 |
| title_full_unstemmed | Green Propolis Compounds (Baccharin and p-Coumaric Acid) Show Beneficial Effects in Mice for Melanoma Induced by B16f10 |
| title_short | Green Propolis Compounds (Baccharin and p-Coumaric Acid) Show Beneficial Effects in Mice for Melanoma Induced by B16f10 |
| title_sort | green propolis compounds baccharin and p coumaric acid show beneficial effects in mice for melanoma induced by b16f10 |
| topic | melanoma skin cancer baccharin coumaric acid cancer therapy |
| url | https://www.mdpi.com/2305-6320/8/5/20 |
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