αAu2S nanoparticles: Fungal-mediated synthesis, structural characterization and bioassay
Luminescent nanoparticles synthesized via bio-based protocols that generate nanoparticles having different chemical compositions along with other functionalities (size and morphology) have received huge attention. We have focused our research on gold sulfide nanoparticles (Au2S NPs) and have biosynt...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-01-01
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| Series: | Green Chemistry Letters and Reviews |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/17518253.2021.1999509 |
| _version_ | 1818965864290975744 |
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| author | Asad Syed Marzouq H. Al Saedi Ali H. Bahkali Abdallah M. Elgorgan Mahesh Kharat Kalpana Pai John Pichtel Absar Ahmad |
| author_facet | Asad Syed Marzouq H. Al Saedi Ali H. Bahkali Abdallah M. Elgorgan Mahesh Kharat Kalpana Pai John Pichtel Absar Ahmad |
| author_sort | Asad Syed |
| collection | DOAJ |
| description | Luminescent nanoparticles synthesized via bio-based protocols that generate nanoparticles having different chemical compositions along with other functionalities (size and morphology) have received huge attention. We have focused our research on gold sulfide nanoparticles (Au2S NPs) and have biosynthesized these NPs using the fungus Humicola sp. The nanoparticles were characterized by Transmission Electron Microscopy, which showed spherical morphology of Au2S. UV–Visible-NIR spectrophotometry, luminescence spectrophotometry, Selected Area Electron Diffraction, Energy Dispersive Analysis of X-rays, and X-ray diffraction were performed. FTIR confirmed that the fungal metabolites including biomolecules secreted in the reaction medium are primarily responsible for nanoparticle synthesis and stabilization. The fungus reduced the precursor solution (HAuCl4 and Na2SO3) and at the same time capped them with secreted biomolecules. The anti-leishmanial activity of Au2S NPs was determined against L. donovani promastigote (Ag83 strain). Au2S NPs displayed less cytotoxicity towards both normal and cancer (Daudi, ZR-75-1) cell lines. Hemocompatibility was determined via hemolysis assays. This novel fungal-based system demonstrates an economical and environmentally benign process for biosynthesis of Au2S nanoparticles which may find application in bioimaging and labeling studies. |
| first_indexed | 2024-12-20T13:23:47Z |
| format | Article |
| id | doaj.art-63e4ae983bd04de7a81f0bb64e38cb4a |
| institution | Directory Open Access Journal |
| issn | 1751-8253 1751-7192 |
| language | English |
| last_indexed | 2024-12-20T13:23:47Z |
| publishDate | 2022-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Green Chemistry Letters and Reviews |
| spelling | doaj.art-63e4ae983bd04de7a81f0bb64e38cb4a2022-12-21T19:39:19ZengTaylor & Francis GroupGreen Chemistry Letters and Reviews1751-82531751-71922022-01-01151596810.1080/17518253.2021.19995091999509αAu2S nanoparticles: Fungal-mediated synthesis, structural characterization and bioassayAsad Syed0Marzouq H. Al Saedi1Ali H. Bahkali2Abdallah M. Elgorgan3Mahesh Kharat4Kalpana Pai5John Pichtel6Absar Ahmad7King Saud UniversityKing Saud UniversityKing Saud UniversityKing Saud UniversitySavitribhai Phule Pune UniversitySavitribhai Phule Pune UniversityBall State UniversityAligarh Muslim UniversityLuminescent nanoparticles synthesized via bio-based protocols that generate nanoparticles having different chemical compositions along with other functionalities (size and morphology) have received huge attention. We have focused our research on gold sulfide nanoparticles (Au2S NPs) and have biosynthesized these NPs using the fungus Humicola sp. The nanoparticles were characterized by Transmission Electron Microscopy, which showed spherical morphology of Au2S. UV–Visible-NIR spectrophotometry, luminescence spectrophotometry, Selected Area Electron Diffraction, Energy Dispersive Analysis of X-rays, and X-ray diffraction were performed. FTIR confirmed that the fungal metabolites including biomolecules secreted in the reaction medium are primarily responsible for nanoparticle synthesis and stabilization. The fungus reduced the precursor solution (HAuCl4 and Na2SO3) and at the same time capped them with secreted biomolecules. The anti-leishmanial activity of Au2S NPs was determined against L. donovani promastigote (Ag83 strain). Au2S NPs displayed less cytotoxicity towards both normal and cancer (Daudi, ZR-75-1) cell lines. Hemocompatibility was determined via hemolysis assays. This novel fungal-based system demonstrates an economical and environmentally benign process for biosynthesis of Au2S nanoparticles which may find application in bioimaging and labeling studies.http://dx.doi.org/10.1080/17518253.2021.1999509gold sulfidebiosynthesishumicola sppromastigotecytotoxicityhemolysis |
| spellingShingle | Asad Syed Marzouq H. Al Saedi Ali H. Bahkali Abdallah M. Elgorgan Mahesh Kharat Kalpana Pai John Pichtel Absar Ahmad αAu2S nanoparticles: Fungal-mediated synthesis, structural characterization and bioassay Green Chemistry Letters and Reviews gold sulfide biosynthesis humicola sp promastigote cytotoxicity hemolysis |
| title | αAu2S nanoparticles: Fungal-mediated synthesis, structural characterization and bioassay |
| title_full | αAu2S nanoparticles: Fungal-mediated synthesis, structural characterization and bioassay |
| title_fullStr | αAu2S nanoparticles: Fungal-mediated synthesis, structural characterization and bioassay |
| title_full_unstemmed | αAu2S nanoparticles: Fungal-mediated synthesis, structural characterization and bioassay |
| title_short | αAu2S nanoparticles: Fungal-mediated synthesis, structural characterization and bioassay |
| title_sort | αau2s nanoparticles fungal mediated synthesis structural characterization and bioassay |
| topic | gold sulfide biosynthesis humicola sp promastigote cytotoxicity hemolysis |
| url | http://dx.doi.org/10.1080/17518253.2021.1999509 |
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