N-acetylcysteine and allopurinol confer synergy in attenuating myocardial ischemia injury via restoring HIF-1α/HO-1 signaling in diabetic rats.

N-acetylcysteine and allopurinol confer synergy in attenuating myocardial ischemia injury via restoring HIF-1α/HO-1 signaling in diabetic rats.

To determine whether or not the antioxidants N-acetylcysteine (NAC) and allopurinol (ALP) confer synergistic cardioprotection against myocardial ischemia/reperfusion (MI/R) injury by stabilizing hypoxia inducible factor 1α (HIF-1α)/heme oxygenase 1 (HO-1) signaling in diabetic myocardium.Control or...

Full description

Bibliographic Details
Main Authors:	Xiaowen Mao, Tingting Wang, Yanan Liu, Michael G Irwin, Jing-song Ou, Xiao-long Liao, Xia Gao, Yuan Xu, Kwok F J Ng, Paul M Vanhoutte, Zhengyuan Xia
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3715528?pdf=render

Similar Items

N-acetylcysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic rats.
by: Tingting Wang, et al.
Published: (2011-01-01)

The role of HIF-1α/HO-1 pathway in hippocampal neuronal ferroptosis in epilepsy
by: Zhen Liang, et al.
Published: (2023-11-01)

Transient hypofibrinogenemia due to allopurinol
by: Yin ZQ, et al.
Published: (2014-09-01)

Allopurinol
by: 982 SIRIM

Allopurinol Protective Effect of Renal Ischemia by Downregulating TNF-α, IL-1β, and IL-6 Response
by: Beatriz Prieto-Moure, et al.
Published: (2017-05-01)

Allopurinol preconditioning attenuates renal ischemia/reperfusion injury by inhibiting HMGB1 expression in a rat model
by: Jiang-qiao Zhou, et al.
Published: (2016-03-01)

Sirtuin4 alleviates severe acute pancreatitis by regulating HIF-1α/HO-1 mediated ferroptosis
by: Yanna Liu, et al.
Published: (2023-10-01)

Protection Against Post-resuscitation Acute Kidney Injury by N-Acetylcysteine via Activation of the Nrf2/HO-1 Pathway
by: Shiwei Wang, et al.
Published: (2022-05-01)

Single Dose of N-Acetylcysteine in Local Anesthesia Increases Expression of HIF1α, MAPK1, TGFβ1 and Growth Factors in Rat Wound Healing
by: Wiktor Paskal, et al.
Published: (2021-08-01)

Allopurinol: Sorrow to the marrow
by: U R Raaju, et al.
Published: (2020-01-01)

Combined intervention with N-acetylcysteine and desipramine alleviated silicosis development by regulating the Nrf2/HO-1 and ASMase/ceramide signaling pathways
by: Meng Tang, et al.
Published: (2022-09-01)

S-nitroso-N-acetylcysteine ameliorates ischemia-reperfusion injury in the steatotic liver
by: Wellington Andraus, et al.
Published: (2010-01-01)

Amelioration of myocardial ischemia/reperfusion injury in diabetes: A narrative review of the mechanisms and clinical applications of dexmedetomidine
by: Meng Sun, et al.
Published: (2022-08-01)

A thermosensitive hydrogel-copper meta-organic framework composite improves hindlimb ischemia therapy through synergistically enhancing HIF-1α production and inhibiting HIF-1α degradation
by: Jinmei Cheng, et al.
Published: (2024-02-01)

Mitophagy mediated by HIF-1α/FUNDC1 signaling in tubular cells protects against renal ischemia/reperfusion injury
by: Wenjun Zhang, et al.
Published: (2024-12-01)

The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo.
by: Jaclyn Sceneay, et al.
Published: (2013-01-01)

Ceftriaxone- and N-acetylcysteine-induced brain tolerance to ischemia: Influence on glutamate levels in focal cerebral ischemia.
by: Weronika Krzyżanowska, et al.
Published: (2017-01-01)

HIF-1α signaling activation by post-ischemia treatment with astragaloside IV attenuates myocardial ischemia-reperfusion injury.
by: Jingwen Si, et al.
Published: (2014-01-01)

Combination Therapy of Allopurinol and Dantrolene and Its Role In The Prevention of Experimental Ischemia Reperfusion Injury Of The Small Intestine
by: Beatriz Prieto-Moure, et al.
Published: (2021-08-01)

Deciphering the Role of Heme Oxygenase-1 (HO-1) Expressing Macrophages in Renal Ischemia-Reperfusion Injury
by: Maxime Rossi, et al.
Published: (2021-03-01)

Renoprotective effect of N-acetylcysteine depends upon the severity of the ischemia reperfusion injury
by: M. Watanabe, et al.
Published: (2021-09-01)

Association of HIF-1α and NDRG2 expression with EMT in gastric cancer tissues
by: Wang Ren-Xiang, et al.
Published: (2019-07-01)

Deferoxamine Treatment Combined With Sevoflurane Postconditioning Attenuates Myocardial Ischemia-Reperfusion Injury by Restoring HIF-1/BNIP3-Mediated Mitochondrial Autophagy in GK Rats
by: Long Yang, et al.
Published: (2020-02-01)

Correction: Ecstasy induces reactive oxygen species, kidney water absorption and rhabdomyolysis in normal rats. Effect of N-acetylcysteine and Allopurinol in oxidative stress and muscle fiber damage.
by: Ana C de Bragança, et al.
Published: (2018-01-01)

Data case Allopurinol Allergy
by: Hardyanto Soebono, Hardyanto
Published: (2022)

Protective Effects of N-acetylcysteine and a Prostaglandin E1 Analog, Alprostadil, Against Hepatic Ischemia: Reperfusion Injury in Rats
by: Cheng-Chu Hsieh, et al.
Published: (2014-01-01)

Expression and significance of HIF-1α and Pax6 in pterygium
by: Xiu-Xia Yin, et al.
Published: (2014-11-01)

Effects of Ascorbic Acid, Alpha-Tocopherol and Allopurinol on Ischemia-Reperfusion Injury in Rabbit Skeletal Muscle: An Experimental Study
by: Bilgehan Erkut, et al.
Published: (2007-01-01)

Effects of Ascorbic Acid, Alpha-Tocopherol and Allopurinol on Ischemia-Reperfusion Injury in Rabbit Skeletal Muscle: An Experimental Study
by: Bilgehan Erkut, et al.
Published: (2007-01-01)

Characterization and functional analysis of hypoxia-inducible factor HIF1α and its inhibitor HIF1αn in tilapia.
by: Hong Lian Li, et al.
Published: (2017-01-01)

The protective role of IL-1Ra on intestinal ischemia reperfusion injury by anti-oxidative stress via Nrf2/HO-1 pathway in rat
by: Chen Jin, et al.
Published: (2019-02-01)

NFAT5 and HIF-1α Coordinate to Regulate NKCC1 Expression in Hippocampal Neurons After Hypoxia-Ischemia
by: Xing-Liang Yang, et al.
Published: (2019-12-01)

Itaconate Suppresses Formation of Neutrophil Extracellular Traps (NETs): Involvement of Hypoxia-Inducible Factor 1α (Hif-1α) and Heme Oxygenase (HO-1)
by: Gabriela Burczyk, et al.
Published: (2022-06-01)

An Evaluation of the Effectiveness of Melatonin and n-Acetylcysteine in Cerebral Ischemia-Reperfusion Injury in Adult Rats
by: Hilal Aydin, et al.
Published: (2023-11-01)

<em>N</em>-Acetylcysteine Reduced Ischemia and Reperfusion Damage Associated with Steatohepatitis in Mice
by: Natalie Chaves Cayuela, et al.
Published: (2020-06-01)

IMPACT OF SEVOFLURANE AND ACETYLCYSTEINE ON ISCHEMIA-REPERFUSION INJURY OF THE LIVER FROM BRAIN-DEAD DONOR
by: A. E. Shcherba, et al.
Published: (2013-03-01)

N-acetylcysteine prevents kidney and lung disturbances in renal ischemia/reperfusion injury in rat
by: Fariba Azarkish, et al.
Published: (2013-01-01)

Cerebral vasculitis following allopurinol treatment.
by: Rothwell, P, et al.
Published: (1996)

Agranulocytosis: an adverse effect of allopurinol treatment
by: Elisa Mari, et al.
Published: (2013-03-01)

Heart failure, oxidative stress and allopurinol
by: Paolo Biagi, et al.
Published: (2005-03-01)