Epipregnanolone as a Positive Modulator of GABA<sub>A</sub> Receptor in Rat Cerebellar and Hippocampus Neurons

Epipregnanolone as a Positive Modulator of GABA<sub>A</sub> Receptor in Rat Cerebellar and Hippocampus Neurons

Epipregnanolone (3β-hydroxy-5β-pregnan-20-one, Epi) is an endogenous steroid with important physiological effects and high affinity for GABA<sub>A</sub> receptors. The effect of Epi on GABA-induced chloride current (<i>I</i><sub>GABA</sub>) in native neurons has h...

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Bibliographic Details
Main Authors: Julia Bukanova, Elena Solntseva, Rodion Kondratenko, Eva Kudova
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Biomolecules
Subjects:
GABA receptor
epipregnanolone
allopregnanolone
isopregnanolone
flumazenil patch clamp
Online Access:https://www.mdpi.com/2218-273X/11/6/791

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