Development of the Gut Microbiome in Children, and Lifetime Implications for Obesity and Cardiometabolic Disease
Emerging evidence suggests that microbiome composition and function is associated with development of obesity and metabolic disease. Microbial colonization expands rapidly following birth, and microbiome composition is particularly variable during infancy. Factors that influence the formation of the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-11-01
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| Series: | Children |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9067/5/12/160 |
| _version_ | 1818664404719239168 |
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| author | Anica I. Mohammadkhah Eoin B. Simpson Stephanie G. Patterson Jane F. Ferguson |
| author_facet | Anica I. Mohammadkhah Eoin B. Simpson Stephanie G. Patterson Jane F. Ferguson |
| author_sort | Anica I. Mohammadkhah |
| collection | DOAJ |
| description | Emerging evidence suggests that microbiome composition and function is associated with development of obesity and metabolic disease. Microbial colonization expands rapidly following birth, and microbiome composition is particularly variable during infancy. Factors that influence the formation of the gut microbiome during infancy and childhood may have a significant impact on development of obesity and metabolic dysfunction, with life-long consequences. In this review, we examine the determinants of gut microbiome composition during infancy and childhood, and evaluate the potential impact on obesity and cardiometabolic risk. |
| first_indexed | 2024-12-17T05:32:12Z |
| format | Article |
| id | doaj.art-63e5b05839354aa899a535e4477a0c84 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-12-17T05:32:12Z |
| publishDate | 2018-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-63e5b05839354aa899a535e4477a0c842022-12-21T22:01:42ZengMDPI AGChildren2227-90672018-11-0151216010.3390/children5120160children5120160Development of the Gut Microbiome in Children, and Lifetime Implications for Obesity and Cardiometabolic DiseaseAnica I. Mohammadkhah0Eoin B. Simpson1Stephanie G. Patterson2Jane F. Ferguson3Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USADivision of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USADivision of Critical Care Medicine, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USADivision of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USAEmerging evidence suggests that microbiome composition and function is associated with development of obesity and metabolic disease. Microbial colonization expands rapidly following birth, and microbiome composition is particularly variable during infancy. Factors that influence the formation of the gut microbiome during infancy and childhood may have a significant impact on development of obesity and metabolic dysfunction, with life-long consequences. In this review, we examine the determinants of gut microbiome composition during infancy and childhood, and evaluate the potential impact on obesity and cardiometabolic risk.https://www.mdpi.com/2227-9067/5/12/160microbiomeobesitycardiometabolic disease |
| spellingShingle | Anica I. Mohammadkhah Eoin B. Simpson Stephanie G. Patterson Jane F. Ferguson Development of the Gut Microbiome in Children, and Lifetime Implications for Obesity and Cardiometabolic Disease Children microbiome obesity cardiometabolic disease |
| title | Development of the Gut Microbiome in Children, and Lifetime Implications for Obesity and Cardiometabolic Disease |
| title_full | Development of the Gut Microbiome in Children, and Lifetime Implications for Obesity and Cardiometabolic Disease |
| title_fullStr | Development of the Gut Microbiome in Children, and Lifetime Implications for Obesity and Cardiometabolic Disease |
| title_full_unstemmed | Development of the Gut Microbiome in Children, and Lifetime Implications for Obesity and Cardiometabolic Disease |
| title_short | Development of the Gut Microbiome in Children, and Lifetime Implications for Obesity and Cardiometabolic Disease |
| title_sort | development of the gut microbiome in children and lifetime implications for obesity and cardiometabolic disease |
| topic | microbiome obesity cardiometabolic disease |
| url | https://www.mdpi.com/2227-9067/5/12/160 |
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