Early Diagnosis in Acute Kidney Failure: Neutrophil Gelatinase Associated Lipocain (NGAL), Kidney Injury Molecule-1 (KIM-1), Interleukine-18 (IL-18), Cystatin C
Objective: We aimed to evaluate the effectiveness of renal biomarkers (NGAL, KIM-1, IL-18, and Cystatin-C) for the diagnosis of acute kidney injury (AKI) in patients in intensive care unit (ICU). Material and Method: We conducted our study in İstanbul University İstanbul Medical Faculty Intensive C...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2014-12-01
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| Series: | Türk Yoğun Bakim Derneği Dergisi |
| Subjects: | |
| Online Access: | http://www.yogunbakimderg.com/article_8669/Early-Diagnosis-In-Acute-Kidney-Failure-Neutrophil-Gelatinase-Associated-Lipocain-ngal-Kidney-Injury-Molecule-1-kim-1-Interleukine-18-il-18-Cystatin-C |
| _version_ | 1828031694935949312 |
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| author | Mehmet İlke Büget Elif Özkilitçi Canan Küçükgergin Şule Seçkin Süleyman Küçükay Yılmaz Yenigün Günseli Orhun İbrahim Özkan Özakıncı Perihan Ergin Özcan |
| author_facet | Mehmet İlke Büget Elif Özkilitçi Canan Küçükgergin Şule Seçkin Süleyman Küçükay Yılmaz Yenigün Günseli Orhun İbrahim Özkan Özakıncı Perihan Ergin Özcan |
| author_sort | Mehmet İlke Büget |
| collection | DOAJ |
| description | Objective: We aimed to evaluate the effectiveness of renal biomarkers (NGAL, KIM-1, IL-18, and Cystatin-C) for the diagnosis of acute kidney injury (AKI) in patients in intensive care unit (ICU).
Material and Method: We conducted our study in İstanbul University İstanbul Medical Faculty Intensive Care Unit. The duration of the study was planned to be one month, during this period, we included all consecutive patients who were older than 18 years of age and who stayed longer than 48 hours in our ICU. Twenty-four patients were included and 144 measurements were performed in these patients. Patients who had AKI at the admission, patients who had AKI during ICU stay and patients who never had AKI, were included to the study. Patients were divided into two groups; the first group was consisted of patients who never had AKI during ICU stay and it was considered as control group, the second group was consisted of patients who had AKI during ICU stay or patients who had AKI prior to ICU admission. NGAL, KIM-1, IL-18 and cystatin C levels were measured every day.
Results: KIM-1 (p<0.01), NGAL (p<0.01), IL-18 (p<0.05) and Cystatin-C (p<0.01) levels were found significantly higher than their control groups for patients with AKI.
Conclusion: Serum NGAL, IL-18, KIM-1 and Cystatin C were determined as valuable biomarkers to diagnose AKI for hospitalized ICU patients. |
| first_indexed | 2024-04-10T14:52:10Z |
| format | Article |
| id | doaj.art-63e66a600e244fae8c1e42db874e7300 |
| institution | Directory Open Access Journal |
| issn | 2146-6416 2147-267X |
| language | English |
| last_indexed | 2024-04-10T14:52:10Z |
| publishDate | 2014-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Yoğun Bakim Derneği Dergisi |
| spelling | doaj.art-63e66a600e244fae8c1e42db874e73002023-02-15T16:07:34ZengGalenos YayineviTürk Yoğun Bakim Derneği Dergisi2146-64162147-267X2014-12-011239410010.4274/tybdd.29494 Early Diagnosis in Acute Kidney Failure: Neutrophil Gelatinase Associated Lipocain (NGAL), Kidney Injury Molecule-1 (KIM-1), Interleukine-18 (IL-18), Cystatin CMehmet İlke Büget0Elif Özkilitçi1Canan Küçükgergin2Şule Seçkin3Süleyman Küçükay4Yılmaz Yenigün5Günseli Orhun6İbrahim Özkan Özakıncı7Perihan Ergin Özcan8İstanbul Üniversitesi İstanbul Tıp Fakültesi, Anesteziyoloji Anabilim Dalı, İstanbul, Türkiyeİstanbul Üniversitesi İstanbul Tıp Fakültesi, Anesteziyoloji Anabilim Dalı, İstanbul, Türkiyeİstanbul Üniversitesi İstanbul Tıp Fakültesi, Biyokimya Anabilim Dalı, İstanbul, Türkiyeİstanbul Üniversitesi İstanbul Tıp Fakültesi, Biyokimya Anabilim Dalı, İstanbul, Türkiyeİstanbul Üniversitesi İstanbul Tıp Fakültesi, Anesteziyoloji Anabilim Dalı, İstanbul, Türkiyeİstanbul Üniversitesi İstanbul Tıp Fakültesi, Anesteziyoloji Anabilim Dalı, İstanbul, Türkiyeİstanbul Üniversitesi İstanbul Tıp Fakültesi, Anesteziyoloji Anabilim Dalı, İstanbul, Türkiyeİstanbul Üniversitesi İstanbul Tıp Fakültesi, Anesteziyoloji Anabilim Dalı, İstanbul, Türkiyeİstanbul Üniversitesi İstanbul Tıp Fakültesi, Anesteziyoloji Anabilim Dalı, İstanbul, TürkiyeObjective: We aimed to evaluate the effectiveness of renal biomarkers (NGAL, KIM-1, IL-18, and Cystatin-C) for the diagnosis of acute kidney injury (AKI) in patients in intensive care unit (ICU). Material and Method: We conducted our study in İstanbul University İstanbul Medical Faculty Intensive Care Unit. The duration of the study was planned to be one month, during this period, we included all consecutive patients who were older than 18 years of age and who stayed longer than 48 hours in our ICU. Twenty-four patients were included and 144 measurements were performed in these patients. Patients who had AKI at the admission, patients who had AKI during ICU stay and patients who never had AKI, were included to the study. Patients were divided into two groups; the first group was consisted of patients who never had AKI during ICU stay and it was considered as control group, the second group was consisted of patients who had AKI during ICU stay or patients who had AKI prior to ICU admission. NGAL, KIM-1, IL-18 and cystatin C levels were measured every day. Results: KIM-1 (p<0.01), NGAL (p<0.01), IL-18 (p<0.05) and Cystatin-C (p<0.01) levels were found significantly higher than their control groups for patients with AKI. Conclusion: Serum NGAL, IL-18, KIM-1 and Cystatin C were determined as valuable biomarkers to diagnose AKI for hospitalized ICU patients.http://www.yogunbakimderg.com/article_8669/Early-Diagnosis-In-Acute-Kidney-Failure-Neutrophil-Gelatinase-Associated-Lipocain-ngal-Kidney-Injury-Molecule-1-kim-1-Interleukine-18-il-18-Cystatin-CNGALIL-18Cystatin CKIM-1acute kidney injury |
| spellingShingle | Mehmet İlke Büget Elif Özkilitçi Canan Küçükgergin Şule Seçkin Süleyman Küçükay Yılmaz Yenigün Günseli Orhun İbrahim Özkan Özakıncı Perihan Ergin Özcan Early Diagnosis in Acute Kidney Failure: Neutrophil Gelatinase Associated Lipocain (NGAL), Kidney Injury Molecule-1 (KIM-1), Interleukine-18 (IL-18), Cystatin C Türk Yoğun Bakim Derneği Dergisi NGAL IL-18 Cystatin C KIM-1 acute kidney injury |
| title | Early Diagnosis in Acute Kidney Failure: Neutrophil Gelatinase Associated Lipocain (NGAL), Kidney Injury Molecule-1 (KIM-1), Interleukine-18 (IL-18), Cystatin C |
| title_full | Early Diagnosis in Acute Kidney Failure: Neutrophil Gelatinase Associated Lipocain (NGAL), Kidney Injury Molecule-1 (KIM-1), Interleukine-18 (IL-18), Cystatin C |
| title_fullStr | Early Diagnosis in Acute Kidney Failure: Neutrophil Gelatinase Associated Lipocain (NGAL), Kidney Injury Molecule-1 (KIM-1), Interleukine-18 (IL-18), Cystatin C |
| title_full_unstemmed | Early Diagnosis in Acute Kidney Failure: Neutrophil Gelatinase Associated Lipocain (NGAL), Kidney Injury Molecule-1 (KIM-1), Interleukine-18 (IL-18), Cystatin C |
| title_short | Early Diagnosis in Acute Kidney Failure: Neutrophil Gelatinase Associated Lipocain (NGAL), Kidney Injury Molecule-1 (KIM-1), Interleukine-18 (IL-18), Cystatin C |
| title_sort | early diagnosis in acute kidney failure neutrophil gelatinase associated lipocain ngal kidney injury molecule 1 kim 1 interleukine 18 il 18 cystatin c |
| topic | NGAL IL-18 Cystatin C KIM-1 acute kidney injury |
| url | http://www.yogunbakimderg.com/article_8669/Early-Diagnosis-In-Acute-Kidney-Failure-Neutrophil-Gelatinase-Associated-Lipocain-ngal-Kidney-Injury-Molecule-1-kim-1-Interleukine-18-il-18-Cystatin-C |
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