The integrated stress response protects against ER stress but is not required for altered translation and lifespan from dietary restriction in Caenorhabditis elegans

The integrated stress response protects against ER stress but is not required for altered translation and lifespan from dietary restriction in Caenorhabditis elegans

The highly conserved integrated stress response (ISR) reduces and redirects mRNA translation in response to certain forms of stress and nutrient limitation. It is activated when kinases phosphorylate a key residue in the alpha subunit of eukaryotic translation initiation factor 2 (eIF2). General Con...

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Bibliographic Details
Main Authors: Zhengxin Ma, Jordan Horrocks, Dilawar A. Mir, Matthew Cox, Marissa Ruzga, Jarod Rollins, Aric N. Rogers
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
integrated stress response
nonsense mediated decay
aging
dietary restriction
endoplasmic reticulum stress
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1263344/full

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