Constitutive knockout of interleukin-6 ameliorates memory deficits and entorhinal astrocytosis in the MRL/lpr mouse model of neuropsychiatric lupus

Constitutive knockout of interleukin-6 ameliorates memory deficits and entorhinal astrocytosis in the MRL/lpr mouse model of neuropsychiatric lupus

Abstract Background Neuropsychiatric lupus (NPSLE) describes the cognitive, memory, and affective emotional burdens faced by many lupus patients. While NPSLE’s pathogenesis has not been fully elucidated, clinical imaging studies and cerebrospinal fluid (CSF) findings, namely elevated interleukin-6 (...

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Bibliographic Details
Main Authors: Joshua Reynolds, Michelle Huang, Yaxi Li, Myriam Meineck, Tamara Moeckel, Julia Weinmann-Menke, Chandra Mohan, Andreas Schwarting, Chaim Putterman
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Neuroinflammation
Subjects:
NPSLE
Interleukin-6
Astrocytosis
Entorhinal cortex
Memory deficits
Online Access:https://doi.org/10.1186/s12974-024-03085-9

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