2-Methyl-4-Oxo-4,5-Dihydro-1<i>H</i>-Pyrrole-3-Carboxylic Acid Phenylamide
2-Methyl-4-oxo-4,5-dihydro-1<i>H</i>-pyrrole-3-carboxylic acid phenylamide was obtained as a single product in an experiment on the cyclization modes of a glycine-derived enamino amide. High yield and operational simplicity are the main features of the presented synthetic procedure. Addi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Molbank |
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| Online Access: | https://www.mdpi.com/1422-8599/2024/1/M1778 |
| _version_ | 1827305444734926848 |
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| author | Plamen Angelov Pavel Yanev |
| author_facet | Plamen Angelov Pavel Yanev |
| author_sort | Plamen Angelov |
| collection | DOAJ |
| description | 2-Methyl-4-oxo-4,5-dihydro-1<i>H</i>-pyrrole-3-carboxylic acid phenylamide was obtained as a single product in an experiment on the cyclization modes of a glycine-derived enamino amide. High yield and operational simplicity are the main features of the presented synthetic procedure. Additionally, this result extends our previous observations on the cyclization reactions of similarly functionalized enamines, by revealing the preferred cyclization pathway under Boc-deprotection conditions. |
| first_indexed | 2024-04-24T17:58:17Z |
| format | Article |
| id | doaj.art-63eb3b4a3f7f41cfb1d246ec716910b7 |
| institution | Directory Open Access Journal |
| issn | 1422-8599 |
| language | English |
| last_indexed | 2024-04-24T17:58:17Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj.art-63eb3b4a3f7f41cfb1d246ec716910b72024-03-27T13:56:38ZengMDPI AGMolbank1422-85992024-02-0120241M177810.3390/M17782-Methyl-4-Oxo-4,5-Dihydro-1<i>H</i>-Pyrrole-3-Carboxylic Acid PhenylamidePlamen Angelov0Pavel Yanev1Department of Organic Chemistry, University of Plovdiv Paisii Hilendarski, 24 Tsar Asen Str., 4000 Plovdiv, BulgariaDepartment of Organic Chemistry, University of Plovdiv Paisii Hilendarski, 24 Tsar Asen Str., 4000 Plovdiv, Bulgaria2-Methyl-4-oxo-4,5-dihydro-1<i>H</i>-pyrrole-3-carboxylic acid phenylamide was obtained as a single product in an experiment on the cyclization modes of a glycine-derived enamino amide. High yield and operational simplicity are the main features of the presented synthetic procedure. Additionally, this result extends our previous observations on the cyclization reactions of similarly functionalized enamines, by revealing the preferred cyclization pathway under Boc-deprotection conditions.https://www.mdpi.com/1422-8599/2024/1/M1778pyrrole-3-carboxylic acidpyrrolin-4-oneβ-enaminoneamide |
| spellingShingle | Plamen Angelov Pavel Yanev 2-Methyl-4-Oxo-4,5-Dihydro-1<i>H</i>-Pyrrole-3-Carboxylic Acid Phenylamide Molbank pyrrole-3-carboxylic acid pyrrolin-4-one β-enaminone amide |
| title | 2-Methyl-4-Oxo-4,5-Dihydro-1<i>H</i>-Pyrrole-3-Carboxylic Acid Phenylamide |
| title_full | 2-Methyl-4-Oxo-4,5-Dihydro-1<i>H</i>-Pyrrole-3-Carboxylic Acid Phenylamide |
| title_fullStr | 2-Methyl-4-Oxo-4,5-Dihydro-1<i>H</i>-Pyrrole-3-Carboxylic Acid Phenylamide |
| title_full_unstemmed | 2-Methyl-4-Oxo-4,5-Dihydro-1<i>H</i>-Pyrrole-3-Carboxylic Acid Phenylamide |
| title_short | 2-Methyl-4-Oxo-4,5-Dihydro-1<i>H</i>-Pyrrole-3-Carboxylic Acid Phenylamide |
| title_sort | 2 methyl 4 oxo 4 5 dihydro 1 i h i pyrrole 3 carboxylic acid phenylamide |
| topic | pyrrole-3-carboxylic acid pyrrolin-4-one β-enaminone amide |
| url | https://www.mdpi.com/1422-8599/2024/1/M1778 |
| work_keys_str_mv | AT plamenangelov 2methyl4oxo45dihydro1ihipyrrole3carboxylicacidphenylamide AT pavelyanev 2methyl4oxo45dihydro1ihipyrrole3carboxylicacidphenylamide |