PFKFB3: A Potential Key to Ocular Angiogenesis
The current treatment for ocular pathological angiogenesis mainly focuses on anti-VEGF signals. This treatment has been confirmed as effective despite the unfavorable side effects and unsatisfactory efficiency. Recently, endothelial cell metabolism, especially glycolysis, has been attracting attenti...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.628317/full |
| _version_ | 1819159952716988416 |
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| author | Zi-Yi Zhou Lin Wang Yu-Sheng Wang Guo-Rui Dou |
| author_facet | Zi-Yi Zhou Lin Wang Yu-Sheng Wang Guo-Rui Dou |
| author_sort | Zi-Yi Zhou |
| collection | DOAJ |
| description | The current treatment for ocular pathological angiogenesis mainly focuses on anti-VEGF signals. This treatment has been confirmed as effective despite the unfavorable side effects and unsatisfactory efficiency. Recently, endothelial cell metabolism, especially glycolysis, has been attracting attention as a potential treatment by an increasing number of researchers. Emerging evidence has shown that regulation of endothelial glycolysis can influence vessel sprouting. This new evidence has raised the potential for novel treatment targets that have been overlooked for a long time. In this review, we discuss the process of endothelial glycolysis as a promising target and consider regulation of the enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as treatment for ocular pathological angiogenesis. |
| first_indexed | 2024-12-22T16:48:44Z |
| format | Article |
| id | doaj.art-63ee33999faa4f968b0cac7f04499662 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-22T16:48:44Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-63ee33999faa4f968b0cac7f044996622022-12-21T18:19:39ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-03-01910.3389/fcell.2021.628317628317PFKFB3: A Potential Key to Ocular AngiogenesisZi-Yi Zhou0Lin Wang1Yu-Sheng Wang2Guo-Rui Dou3Department of Ophthalmology, Xijing Hospital, Eye Institute of Chinese PLA, Fourth Military Medical University, Xi’an, ChinaDepartment of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, ChinaDepartment of Ophthalmology, Xijing Hospital, Eye Institute of Chinese PLA, Fourth Military Medical University, Xi’an, ChinaDepartment of Ophthalmology, Xijing Hospital, Eye Institute of Chinese PLA, Fourth Military Medical University, Xi’an, ChinaThe current treatment for ocular pathological angiogenesis mainly focuses on anti-VEGF signals. This treatment has been confirmed as effective despite the unfavorable side effects and unsatisfactory efficiency. Recently, endothelial cell metabolism, especially glycolysis, has been attracting attention as a potential treatment by an increasing number of researchers. Emerging evidence has shown that regulation of endothelial glycolysis can influence vessel sprouting. This new evidence has raised the potential for novel treatment targets that have been overlooked for a long time. In this review, we discuss the process of endothelial glycolysis as a promising target and consider regulation of the enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as treatment for ocular pathological angiogenesis.https://www.frontiersin.org/articles/10.3389/fcell.2021.628317/fullocular angiogenesisPFKFB3endothelial metabolismglycolysisendothelial cell |
| spellingShingle | Zi-Yi Zhou Lin Wang Yu-Sheng Wang Guo-Rui Dou PFKFB3: A Potential Key to Ocular Angiogenesis Frontiers in Cell and Developmental Biology ocular angiogenesis PFKFB3 endothelial metabolism glycolysis endothelial cell |
| title | PFKFB3: A Potential Key to Ocular Angiogenesis |
| title_full | PFKFB3: A Potential Key to Ocular Angiogenesis |
| title_fullStr | PFKFB3: A Potential Key to Ocular Angiogenesis |
| title_full_unstemmed | PFKFB3: A Potential Key to Ocular Angiogenesis |
| title_short | PFKFB3: A Potential Key to Ocular Angiogenesis |
| title_sort | pfkfb3 a potential key to ocular angiogenesis |
| topic | ocular angiogenesis PFKFB3 endothelial metabolism glycolysis endothelial cell |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.628317/full |
| work_keys_str_mv | AT ziyizhou pfkfb3apotentialkeytoocularangiogenesis AT linwang pfkfb3apotentialkeytoocularangiogenesis AT yushengwang pfkfb3apotentialkeytoocularangiogenesis AT guoruidou pfkfb3apotentialkeytoocularangiogenesis |