PFKFB3: A Potential Key to Ocular Angiogenesis

PFKFB3: A Potential Key to Ocular Angiogenesis

The current treatment for ocular pathological angiogenesis mainly focuses on anti-VEGF signals. This treatment has been confirmed as effective despite the unfavorable side effects and unsatisfactory efficiency. Recently, endothelial cell metabolism, especially glycolysis, has been attracting attenti...

Full description

Bibliographic Details
Main Authors:	Zi-Yi Zhou, Lin Wang, Yu-Sheng Wang, Guo-Rui Dou
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-03-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	ocular angiogenesis PFKFB3 endothelial metabolism glycolysis endothelial cell
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2021.628317/full

Similar Items

PFKFB3 in neovascular eye disease: unraveling mechanisms and exploring therapeutic strategies
by: Peiyu Liu, et al.
Published: (2024-02-01)

The PFKFB3 Inhibitor AZ67 Inhibits Angiogenesis Independently of Glycolysis Inhibition
by: Besa Emini Veseli, et al.
Published: (2021-05-01)

MALAT1 sponges miR-26a and miR-26b to regulate endothelial cell angiogenesis via PFKFB3-driven glycolysis in early-onset preeclampsia
by: Qi Li, et al.
Published: (2021-03-01)

Role of PFKFB3-driven glycolysis in sepsis
by: Min Xiao, et al.
Published: (2023-12-01)

PFKFB3-mediated glycometabolism reprogramming modulates endothelial differentiation and angiogenic capacity of placenta-derived mesenchymal stem cells
by: Yang Zhang, et al.
Published: (2022-08-01)

Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis
by: Xin Tracy Liu, et al.
Published: (2024-01-01)

Placenta-Targeted Nanoparticles Loaded with PFKFB3 Overexpression Plasmids Enhance Angiogenesis and Placental Function
by: Qi Li, et al.
Published: (2022-11-01)

Identification of PFKFB2 as a key gene for the transition from acute to old myocardial infarction in peripheral blood
by: Xiangyu Yang, et al.
Published: (2022-12-01)

Deficiency of Myeloid Pfkfb3 Protects Mice From Lung Edema and Cardiac Dysfunction in LPS-Induced Endotoxemia
by: Jiean Xu, et al.
Published: (2021-09-01)

Myeloid PFKFB3-mediated glycolysis promotes kidney fibrosis
by: Qiuhua Yang, et al.
Published: (2023-11-01)

Canonical and Non-Canonical Roles of PFKFB3 in Brain Tumors
by: Reinier Alvarez, et al.
Published: (2021-10-01)

Endothelial Cell Glucose Metabolism and Angiogenesis
by: Wa Du, et al.
Published: (2021-02-01)

HSF1 promotes endometriosis development and glycolysis by up-regulating PFKFB3 expression
by: Yixin Wang, et al.
Published: (2021-06-01)

Angiogenesis revisited from a metabolic perspective: role and therapeutic implications of endothelial cell metabolism
by: Nihed Draoui, et al.
Published: (2017-01-01)

PFKFB4 Drives the Oncogenicity in TP53-Mutated Hepatocellular Carcinoma in a Phosphatase-Dependent MannerSummary
by: Charles Shing Kam, et al.
Published: (2023-01-01)

PFKFB3-Mediated Glycolysis Boosts Fibroblast Activation and Subsequent Kidney Fibrosis
by: Qiuhua Yang, et al.
Published: (2023-08-01)

Anlotinib Inhibits PFKFB3-Driven Glycolysis in Myofibroblasts to Reverse Pulmonary Fibrosis
by: Weimou Chen, et al.
Published: (2021-09-01)

Inhibition of AMPK/PFKFB3 mediated glycolysis synergizes with penfluridol to suppress gallbladder cancer growth
by: Jiahao Hu, et al.
Published: (2022-07-01)

Positive regulation of PFKFB3 by PIM2 promotes glycolysis and paclitaxel resistance in breast cancer
by: Chao Lu, et al.
Published: (2021-04-01)

Increased stromal PFKFB3-mediated glycolysis in inflammatory bowel disease contributes to intestinal inflammation
by: Zhou Zhou, et al.
Published: (2022-11-01)

KDM3A-mediated SP1 activates PFKFB4 transcription to promote aerobic glycolysis in osteosarcoma and augment tumor development
by: Wei Wang, et al.
Published: (2022-05-01)

Overexpression of PFKFB3 promotes cell glycolysis and proliferation in renal cell carcinoma
by: Jun Li, et al.
Published: (2022-01-01)

Recent advances in ocular drug delivery systems and targeting VEGF receptors for management of ocular angiogenesis: A comprehensive review
by: Soumya Narayana, et al.
Published: (2021-09-01)

TRAF7 inhibits glycolysis to potentiate growth inhibition and apoptosis of myeloid leukemia cells via regulating the KLF2-PFKFB3 axis
by: Lin Zou, et al.
Published: (2023-06-01)

Partial Inhibition of the 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase-3 (PFKFB3) Enzyme in Myeloid Cells Does Not Affect Atherosclerosis
by: Renée J. H. A. Tillie, et al.
Published: (2021-08-01)

RORα inhibits gastric cancer proliferation through attenuating G6PD and PFKFB3 induced glycolytic activity
by: Xiaoshan Wang, et al.
Published: (2024-01-01)

The metabolic role of PFKFB4 in androgen-independent growth in vitro and PFKFB4 expression in human prostate cancer tissue
by: Ximing Li, et al.
Published: (2020-06-01)

Therapeutic targeting of PFKFB3 and PFKFB4 in multiple myeloma cells under hypoxic conditions
by: Seiichi Okabe, et al.
Published: (2022-05-01)

Endothelial GABBR2 Regulates Post-ischemic Angiogenesis by Inhibiting the Glycolysis Pathway
by: Hongze Zhang, et al.
Published: (2021-08-01)

Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo
by: Tiago De Oliveira, et al.
Published: (2021-02-01)

Long noncoding RNA LINC00930 promotes PFKFB3-mediated tumor glycolysis and cell proliferation in nasopharyngeal carcinoma
by: Baoyu He, et al.
Published: (2022-02-01)

Role of PFKFB3 and PFKFB4 in Cancer: Genetic Basis, Impact on Disease Development/Progression, and Potential as Therapeutic Targets
by: Krzysztof Kotowski, et al.
Published: (2021-02-01)

Advances in endothelial cell lipid metabolism and tumor angiogenesis
by: Shi-feng Yan, et al.
Published: (2024-01-01)

KDM2A Targets PFKFB3 for Ubiquitylation to Inhibit the Proliferation and Angiogenesis of Multiple Myeloma Cells
by: Xinling Liu, et al.
Published: (2021-05-01)

Carbonic Anhydrase IX Promotes Human Cervical Cancer Cell Motility by Regulating PFKFB4 Expression
by: Min-Chieh Hsin, et al.
Published: (2021-03-01)

PFKFB3 downregulation aggravates Angiotensin II-induced podocyte detachment
by: Xiaoxiao Huang, et al.
Published: (2023-12-01)

Effect of PFKFB4 on the Prognosis and Immune Regulation of NSCLC and Its Mechanism
by: Zhou Y, et al.
Published: (2022-08-01)

Mitogen-Inducible Gene 6 Inhibits Angiogenesis by Binding to SHC1 and Suppressing Its Phosphorylation
by: Lixian Liu, et al.
Published: (2021-02-01)

The Immunomodulator Dimethyl Itaconate Inhibits Several Key Steps of Angiogenesis in Cultured Endothelial Cells
by: Isabel Vidal, et al.
Published: (2022-12-01)

COCO/DAND5 inhibits developmental and pathological ocular angiogenesis
by: Natalija Popovic, et al.
Published: (2021-03-01)