Viral Membrane Fusion and the Transmembrane Domain
Initiation of host cell infection by an enveloped virus requires a viral-to-host cell membrane fusion event. This event is mediated by at least one viral transmembrane glycoprotein, termed the fusion protein, which is a key therapeutic target. Viral fusion proteins have been studied for decades, and...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/12/7/693 |
| _version_ | 1797564013117177856 |
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| author | Chelsea T. Barrett Rebecca Ellis Dutch |
| author_facet | Chelsea T. Barrett Rebecca Ellis Dutch |
| author_sort | Chelsea T. Barrett |
| collection | DOAJ |
| description | Initiation of host cell infection by an enveloped virus requires a viral-to-host cell membrane fusion event. This event is mediated by at least one viral transmembrane glycoprotein, termed the fusion protein, which is a key therapeutic target. Viral fusion proteins have been studied for decades, and numerous critical insights into their function have been elucidated. However, the transmembrane region remains one of the most poorly understood facets of these proteins. In the past ten years, the field has made significant advances in understanding the role of the membrane-spanning region of viral fusion proteins. We summarize developments made in the past decade that have contributed to the understanding of the transmembrane region of viral fusion proteins, highlighting not only their critical role in the membrane fusion process, but further demonstrating their involvement in several aspects of the viral lifecycle. |
| first_indexed | 2024-03-10T18:51:20Z |
| format | Article |
| id | doaj.art-63ee3baa86cf46289f2cf51ce54cb8f5 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T18:51:20Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-63ee3baa86cf46289f2cf51ce54cb8f52023-11-20T05:06:22ZengMDPI AGViruses1999-49152020-06-0112769310.3390/v12070693Viral Membrane Fusion and the Transmembrane DomainChelsea T. Barrett0Rebecca Ellis Dutch1Department of Molecular and Cellular Biochemistry, University of Kentucky, 741 South Limestone Street, Lexington, KY 40536, USADepartment of Molecular and Cellular Biochemistry, University of Kentucky, 741 South Limestone Street, Lexington, KY 40536, USAInitiation of host cell infection by an enveloped virus requires a viral-to-host cell membrane fusion event. This event is mediated by at least one viral transmembrane glycoprotein, termed the fusion protein, which is a key therapeutic target. Viral fusion proteins have been studied for decades, and numerous critical insights into their function have been elucidated. However, the transmembrane region remains one of the most poorly understood facets of these proteins. In the past ten years, the field has made significant advances in understanding the role of the membrane-spanning region of viral fusion proteins. We summarize developments made in the past decade that have contributed to the understanding of the transmembrane region of viral fusion proteins, highlighting not only their critical role in the membrane fusion process, but further demonstrating their involvement in several aspects of the viral lifecycle.https://www.mdpi.com/1999-4915/12/7/693viral fusion proteintransmembrane domain |
| spellingShingle | Chelsea T. Barrett Rebecca Ellis Dutch Viral Membrane Fusion and the Transmembrane Domain Viruses viral fusion protein transmembrane domain |
| title | Viral Membrane Fusion and the Transmembrane Domain |
| title_full | Viral Membrane Fusion and the Transmembrane Domain |
| title_fullStr | Viral Membrane Fusion and the Transmembrane Domain |
| title_full_unstemmed | Viral Membrane Fusion and the Transmembrane Domain |
| title_short | Viral Membrane Fusion and the Transmembrane Domain |
| title_sort | viral membrane fusion and the transmembrane domain |
| topic | viral fusion protein transmembrane domain |
| url | https://www.mdpi.com/1999-4915/12/7/693 |
| work_keys_str_mv | AT chelseatbarrett viralmembranefusionandthetransmembranedomain AT rebeccaellisdutch viralmembranefusionandthetransmembranedomain |