Development of a Multi-Study Repository to Support Research on Veteran Health: The VA Cooperative Studies Program Epidemiology Center-Durham (CSPEC-Durham) Data and Specimen Repository
Federal agencies, including the Department of Veterans Affairs (VA), have prioritized improved access to scientific data and results collected through federally funded research. Our VA Cooperative Studies Program Epidemiology Center in Durham, North Carolina (CSPEC-Durham) assembled a repository of...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-02-01
|
| Series: | Frontiers in Public Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2021.612806/full |
| _version_ | 1819051108154212352 |
|---|---|
| author | Meghan C. O'Leary R. Lawrence Whitley Ashlyn Press Dawn Provenzale Dawn Provenzale Christina D. Williams Christina D. Williams Blair Chesnut Blair Chesnut Rodney Jones Rodney Jones Thomas S. Redding Kellie J. Sims |
| author_facet | Meghan C. O'Leary R. Lawrence Whitley Ashlyn Press Dawn Provenzale Dawn Provenzale Christina D. Williams Christina D. Williams Blair Chesnut Blair Chesnut Rodney Jones Rodney Jones Thomas S. Redding Kellie J. Sims |
| author_sort | Meghan C. O'Leary |
| collection | DOAJ |
| description | Federal agencies, including the Department of Veterans Affairs (VA), have prioritized improved access to scientific data and results collected through federally funded research. Our VA Cooperative Studies Program Epidemiology Center in Durham, North Carolina (CSPEC-Durham) assembled a repository of data and specimens collected through multiple studies on Veteran health issues to facilitate future research in these areas. We developed a single protocol, request process that includes scientific and ethical review of all applications, and a database architecture using metadata (common variable descriptors) to securely store and share data across diverse studies. In addition, we created a mechanism to allow data and specimens collected through older studies in which re-use was not addressed in the study protocol or consent forms to be shared if the future research is within the scope of the original consent. Our CSPEC-Durham Data and Specimen Repository currently includes research data, genomic data, and study specimens (e.g., DNA, blood) for three content areas: colorectal cancer, amyotrophic lateral sclerosis, and Gulf War research. The linking of the study specimens and research data can support additional genetic analyses and related research to improve Veterans' health. |
| first_indexed | 2024-12-21T11:58:42Z |
| format | Article |
| id | doaj.art-63ef29efc6b44482b18a2ad831af10aa |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-12-21T11:58:42Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-63ef29efc6b44482b18a2ad831af10aa2022-12-21T19:04:52ZengFrontiers Media S.A.Frontiers in Public Health2296-25652021-02-01910.3389/fpubh.2021.612806612806Development of a Multi-Study Repository to Support Research on Veteran Health: The VA Cooperative Studies Program Epidemiology Center-Durham (CSPEC-Durham) Data and Specimen RepositoryMeghan C. O'Leary0R. Lawrence Whitley1Ashlyn Press2Dawn Provenzale3Dawn Provenzale4Christina D. Williams5Christina D. Williams6Blair Chesnut7Blair Chesnut8Rodney Jones9Rodney Jones10Thomas S. Redding11Kellie J. Sims12Cooperative Studies Program Epidemiology Center-Durham, Durham Veterans Affairs Health Care System, Durham, NC, United StatesRTI International, Research Triangle Park, NC, United StatesCooperative Studies Program Epidemiology Center-Durham, Durham Veterans Affairs Health Care System, Durham, NC, United StatesCooperative Studies Program Epidemiology Center-Durham, Durham Veterans Affairs Health Care System, Durham, NC, United StatesDuke University Medical Center, Durham, NC, United StatesCooperative Studies Program Epidemiology Center-Durham, Durham Veterans Affairs Health Care System, Durham, NC, United StatesDuke University Medical Center, Durham, NC, United StatesCooperative Studies Program Epidemiology Center-Durham, Durham Veterans Affairs Health Care System, Durham, NC, United StatesDuke Molecular Physiology Institute, School of Medicine, Duke University, Durham, NC, United StatesCooperative Studies Program Epidemiology Center-Durham, Durham Veterans Affairs Health Care System, Durham, NC, United StatesDuke Molecular Physiology Institute, School of Medicine, Duke University, Durham, NC, United StatesCooperative Studies Program Epidemiology Center-Durham, Durham Veterans Affairs Health Care System, Durham, NC, United StatesCooperative Studies Program Epidemiology Center-Durham, Durham Veterans Affairs Health Care System, Durham, NC, United StatesFederal agencies, including the Department of Veterans Affairs (VA), have prioritized improved access to scientific data and results collected through federally funded research. Our VA Cooperative Studies Program Epidemiology Center in Durham, North Carolina (CSPEC-Durham) assembled a repository of data and specimens collected through multiple studies on Veteran health issues to facilitate future research in these areas. We developed a single protocol, request process that includes scientific and ethical review of all applications, and a database architecture using metadata (common variable descriptors) to securely store and share data across diverse studies. In addition, we created a mechanism to allow data and specimens collected through older studies in which re-use was not addressed in the study protocol or consent forms to be shared if the future research is within the scope of the original consent. Our CSPEC-Durham Data and Specimen Repository currently includes research data, genomic data, and study specimens (e.g., DNA, blood) for three content areas: colorectal cancer, amyotrophic lateral sclerosis, and Gulf War research. The linking of the study specimens and research data can support additional genetic analyses and related research to improve Veterans' health.https://www.frontiersin.org/articles/10.3389/fpubh.2021.612806/fullrepositorydata sharingveteranbiospecimengenomics |
| spellingShingle | Meghan C. O'Leary R. Lawrence Whitley Ashlyn Press Dawn Provenzale Dawn Provenzale Christina D. Williams Christina D. Williams Blair Chesnut Blair Chesnut Rodney Jones Rodney Jones Thomas S. Redding Kellie J. Sims Development of a Multi-Study Repository to Support Research on Veteran Health: The VA Cooperative Studies Program Epidemiology Center-Durham (CSPEC-Durham) Data and Specimen Repository Frontiers in Public Health repository data sharing veteran biospecimen genomics |
| title | Development of a Multi-Study Repository to Support Research on Veteran Health: The VA Cooperative Studies Program Epidemiology Center-Durham (CSPEC-Durham) Data and Specimen Repository |
| title_full | Development of a Multi-Study Repository to Support Research on Veteran Health: The VA Cooperative Studies Program Epidemiology Center-Durham (CSPEC-Durham) Data and Specimen Repository |
| title_fullStr | Development of a Multi-Study Repository to Support Research on Veteran Health: The VA Cooperative Studies Program Epidemiology Center-Durham (CSPEC-Durham) Data and Specimen Repository |
| title_full_unstemmed | Development of a Multi-Study Repository to Support Research on Veteran Health: The VA Cooperative Studies Program Epidemiology Center-Durham (CSPEC-Durham) Data and Specimen Repository |
| title_short | Development of a Multi-Study Repository to Support Research on Veteran Health: The VA Cooperative Studies Program Epidemiology Center-Durham (CSPEC-Durham) Data and Specimen Repository |
| title_sort | development of a multi study repository to support research on veteran health the va cooperative studies program epidemiology center durham cspec durham data and specimen repository |
| topic | repository data sharing veteran biospecimen genomics |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2021.612806/full |
| work_keys_str_mv | AT meghancoleary developmentofamultistudyrepositorytosupportresearchonveteranhealththevacooperativestudiesprogramepidemiologycenterdurhamcspecdurhamdataandspecimenrepository AT rlawrencewhitley developmentofamultistudyrepositorytosupportresearchonveteranhealththevacooperativestudiesprogramepidemiologycenterdurhamcspecdurhamdataandspecimenrepository AT ashlynpress developmentofamultistudyrepositorytosupportresearchonveteranhealththevacooperativestudiesprogramepidemiologycenterdurhamcspecdurhamdataandspecimenrepository AT dawnprovenzale developmentofamultistudyrepositorytosupportresearchonveteranhealththevacooperativestudiesprogramepidemiologycenterdurhamcspecdurhamdataandspecimenrepository AT dawnprovenzale developmentofamultistudyrepositorytosupportresearchonveteranhealththevacooperativestudiesprogramepidemiologycenterdurhamcspecdurhamdataandspecimenrepository AT christinadwilliams developmentofamultistudyrepositorytosupportresearchonveteranhealththevacooperativestudiesprogramepidemiologycenterdurhamcspecdurhamdataandspecimenrepository AT christinadwilliams developmentofamultistudyrepositorytosupportresearchonveteranhealththevacooperativestudiesprogramepidemiologycenterdurhamcspecdurhamdataandspecimenrepository AT blairchesnut developmentofamultistudyrepositorytosupportresearchonveteranhealththevacooperativestudiesprogramepidemiologycenterdurhamcspecdurhamdataandspecimenrepository AT blairchesnut developmentofamultistudyrepositorytosupportresearchonveteranhealththevacooperativestudiesprogramepidemiologycenterdurhamcspecdurhamdataandspecimenrepository AT rodneyjones developmentofamultistudyrepositorytosupportresearchonveteranhealththevacooperativestudiesprogramepidemiologycenterdurhamcspecdurhamdataandspecimenrepository AT rodneyjones developmentofamultistudyrepositorytosupportresearchonveteranhealththevacooperativestudiesprogramepidemiologycenterdurhamcspecdurhamdataandspecimenrepository AT thomassredding developmentofamultistudyrepositorytosupportresearchonveteranhealththevacooperativestudiesprogramepidemiologycenterdurhamcspecdurhamdataandspecimenrepository AT kelliejsims developmentofamultistudyrepositorytosupportresearchonveteranhealththevacooperativestudiesprogramepidemiologycenterdurhamcspecdurhamdataandspecimenrepository |