Screening of Bioactive Ingredients in Ligusticum Chuanxiong Hort for Protection against Myocardial Ischemia
Background/Aims: To study the spectrum-effect relationship and effective components of Ligusticum Chuanxiong Hort. (LCH) on the protection of canine myocardial ischemia. Methods: Fingerprint spectrum of LCH extracts was developed using high performance liquid chromatography (HPLC), and a canine mode...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cell Physiol Biochem Press GmbH & Co KG
2016-12-01
|
| Series: | Cellular Physiology and Biochemistry |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/453137 |
| _version_ | 1811228056304484352 |
|---|---|
| author | Xu Liu Xiuzhong Li Songgang Ji Xiaobo Cui Mingchun Li |
| author_facet | Xu Liu Xiuzhong Li Songgang Ji Xiaobo Cui Mingchun Li |
| author_sort | Xu Liu |
| collection | DOAJ |
| description | Background/Aims: To study the spectrum-effect relationship and effective components of Ligusticum Chuanxiong Hort. (LCH) on the protection of canine myocardial ischemia. Methods: Fingerprint spectrum of LCH extracts was developed using high performance liquid chromatography (HPLC), and a canine model of acute myocardial ischemia was established by ligating the coronary artery. Bivariate correlation analysis and multivariate regression analysis were used to correlate the pharmacodynamics of LCH extract and its common peaks in HPLC. Results: The bioactive components of LCH were ligustrazine, ferulic acid, cnidilide and ligustilide. Ligustrazine and ferulic acid could significantly reduce serum lactic acid in canine model of acute myocardial ischemia, while ligustilide could significantly reduce the elevation of serum free fatty acid. Conclusions: The spectrum-effect relationship study shows that the effective components of LCH are ligustrazine, ferulic acid, cnidilide and ligustilide, which have protective effect on myocardial ischemia. |
| first_indexed | 2024-04-12T09:52:05Z |
| format | Article |
| id | doaj.art-63f07021325f4f45aa8a8fd9d2881448 |
| institution | Directory Open Access Journal |
| issn | 1015-8987 1421-9778 |
| language | English |
| last_indexed | 2024-04-12T09:52:05Z |
| publishDate | 2016-12-01 |
| publisher | Cell Physiol Biochem Press GmbH & Co KG |
| record_format | Article |
| series | Cellular Physiology and Biochemistry |
| spelling | doaj.art-63f07021325f4f45aa8a8fd9d28814482022-12-22T03:37:48ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782016-12-01403-477078010.1159/000453137453137Screening of Bioactive Ingredients in Ligusticum Chuanxiong Hort for Protection against Myocardial IschemiaXu LiuXiuzhong LiSonggang JiXiaobo CuiMingchun LiBackground/Aims: To study the spectrum-effect relationship and effective components of Ligusticum Chuanxiong Hort. (LCH) on the protection of canine myocardial ischemia. Methods: Fingerprint spectrum of LCH extracts was developed using high performance liquid chromatography (HPLC), and a canine model of acute myocardial ischemia was established by ligating the coronary artery. Bivariate correlation analysis and multivariate regression analysis were used to correlate the pharmacodynamics of LCH extract and its common peaks in HPLC. Results: The bioactive components of LCH were ligustrazine, ferulic acid, cnidilide and ligustilide. Ligustrazine and ferulic acid could significantly reduce serum lactic acid in canine model of acute myocardial ischemia, while ligustilide could significantly reduce the elevation of serum free fatty acid. Conclusions: The spectrum-effect relationship study shows that the effective components of LCH are ligustrazine, ferulic acid, cnidilide and ligustilide, which have protective effect on myocardial ischemia.http://www.karger.com/Article/FullText/453137Ligusticum Chuanxiong HortMyocardial ischemia, spectrum-effect relationship |
| spellingShingle | Xu Liu Xiuzhong Li Songgang Ji Xiaobo Cui Mingchun Li Screening of Bioactive Ingredients in Ligusticum Chuanxiong Hort for Protection against Myocardial Ischemia Cellular Physiology and Biochemistry Ligusticum Chuanxiong Hort Myocardial ischemia, spectrum-effect relationship |
| title | Screening of Bioactive Ingredients in Ligusticum Chuanxiong Hort for Protection against Myocardial Ischemia |
| title_full | Screening of Bioactive Ingredients in Ligusticum Chuanxiong Hort for Protection against Myocardial Ischemia |
| title_fullStr | Screening of Bioactive Ingredients in Ligusticum Chuanxiong Hort for Protection against Myocardial Ischemia |
| title_full_unstemmed | Screening of Bioactive Ingredients in Ligusticum Chuanxiong Hort for Protection against Myocardial Ischemia |
| title_short | Screening of Bioactive Ingredients in Ligusticum Chuanxiong Hort for Protection against Myocardial Ischemia |
| title_sort | screening of bioactive ingredients in ligusticum chuanxiong hort for protection against myocardial ischemia |
| topic | Ligusticum Chuanxiong Hort Myocardial ischemia, spectrum-effect relationship |
| url | http://www.karger.com/Article/FullText/453137 |
| work_keys_str_mv | AT xuliu screeningofbioactiveingredientsinligusticumchuanxionghortforprotectionagainstmyocardialischemia AT xiuzhongli screeningofbioactiveingredientsinligusticumchuanxionghortforprotectionagainstmyocardialischemia AT songgangji screeningofbioactiveingredientsinligusticumchuanxionghortforprotectionagainstmyocardialischemia AT xiaobocui screeningofbioactiveingredientsinligusticumchuanxionghortforprotectionagainstmyocardialischemia AT mingchunli screeningofbioactiveingredientsinligusticumchuanxionghortforprotectionagainstmyocardialischemia |