Prediction of Patient Hepatic Encephalopathy Risk with Freiburg Index of Post-TIPS Survival Score Following Transjugular Intrahepatic Portosystemic Shunts: A Retrospective Study
Weimin Cai,1 Beishi Zheng,2 Xinran Lin,1 Wei Wu,1 Chao Chen1 1Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China; 2Department of Internal Medicine, Woodhull Medical Center, Brooklyn, NY, 11206, USACo...
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Dove Medical Press
2022-04-01
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| Series: | International Journal of General Medicine |
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| Online Access: | https://www.dovepress.com/prediction-of-patient-hepatic-encephalopathy-risk-with-freiburg-index--peer-reviewed-fulltext-article-IJGM |
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| author | Cai W Zheng B Lin X Wu W Chen C |
| author_facet | Cai W Zheng B Lin X Wu W Chen C |
| author_sort | Cai W |
| collection | DOAJ |
| description | Weimin Cai,1 Beishi Zheng,2 Xinran Lin,1 Wei Wu,1 Chao Chen1 1Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China; 2Department of Internal Medicine, Woodhull Medical Center, Brooklyn, NY, 11206, USACorrespondence: Chao Chen, Department of Gastroenterology and Hepatology, the First Affiliated Hospital of Wenzhou Medical University, No. 2, Fuxue Lane, Wenzhou, 325000, People’s Republic of China, Tel +86 18857838243, Fax +86 576 87755312, Email chenchao210213@163.comBackground: Hepatic encephalopathy is a complication of portal hypertension. The Freiburg index of transjugular portosystemic shunt (TIPS) and patient outcomes have recently been described. This retrospective study was conducted at a single center in China and included 241 patients with portal hypertension who underwent TIPS implantation to evaluate the Freiburg index of post-TIPS survival score (FIPS) to predict hepatic encephalopathy.Methods: A single-center retrospective study including 241 patients who underwent TIPS operation between April 2015 and July 2019 was conducted. Clinical demographics and relevant clinical parameters within 24h after admission were collected. The prediction performances of FIPS, Child–Pugh and the model for end-stage liver disease (MELD) scores were compared by decision curve analysis and receiver operating characteristic (ROC) curve analysis. In addition, multivariate analyses were performed to identify independent predictors.Results: Eighty-three out of 241 patients (34.4%) finally developed post-TIPS hepatic encephalopathy. The area under the ROC curve of FIPS was 0.744 (95% confidence interval: 0.684– 0.798). FIPS was identified as an independent risk factor for post-TIPS hepatic encephalopathy (hazard ratio: 2.23, 95% confidence interval: 1.71– 2.90, p< 0.001). Moreover, we further grouped the FIPS scores into two categories (FIPS ≤-0.97, low-risk; FIPS >-0.97, high risk) to improve its applicability. Patients with high FIPS scores had a significantly higher incidence of hepatic encephalopathy than patients with low FIPS scores (P< 0.05).Conclusion: This study showed that FIPS could be used to evaluate the risk of hepatic encephalopathy in this patient group with improved predictive performance when compared with the Child–Pugh and MELD scores.Keywords: transjugular intrahepatic portosystemic shunts, hepatic encephalopathy, Freiburg index of post-TIPS survival, model for end-stage liver disease |
| first_indexed | 2024-04-14T05:15:26Z |
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| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-04-14T05:15:26Z |
| publishDate | 2022-04-01 |
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| spelling | doaj.art-63f0bb8da9ac409a935636caaeed981b2022-12-22T02:10:23ZengDove Medical PressInternational Journal of General Medicine1178-70742022-04-01Volume 154007401674489Prediction of Patient Hepatic Encephalopathy Risk with Freiburg Index of Post-TIPS Survival Score Following Transjugular Intrahepatic Portosystemic Shunts: A Retrospective StudyCai WZheng BLin XWu WChen CWeimin Cai,1 Beishi Zheng,2 Xinran Lin,1 Wei Wu,1 Chao Chen1 1Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China; 2Department of Internal Medicine, Woodhull Medical Center, Brooklyn, NY, 11206, USACorrespondence: Chao Chen, Department of Gastroenterology and Hepatology, the First Affiliated Hospital of Wenzhou Medical University, No. 2, Fuxue Lane, Wenzhou, 325000, People’s Republic of China, Tel +86 18857838243, Fax +86 576 87755312, Email chenchao210213@163.comBackground: Hepatic encephalopathy is a complication of portal hypertension. The Freiburg index of transjugular portosystemic shunt (TIPS) and patient outcomes have recently been described. This retrospective study was conducted at a single center in China and included 241 patients with portal hypertension who underwent TIPS implantation to evaluate the Freiburg index of post-TIPS survival score (FIPS) to predict hepatic encephalopathy.Methods: A single-center retrospective study including 241 patients who underwent TIPS operation between April 2015 and July 2019 was conducted. Clinical demographics and relevant clinical parameters within 24h after admission were collected. The prediction performances of FIPS, Child–Pugh and the model for end-stage liver disease (MELD) scores were compared by decision curve analysis and receiver operating characteristic (ROC) curve analysis. In addition, multivariate analyses were performed to identify independent predictors.Results: Eighty-three out of 241 patients (34.4%) finally developed post-TIPS hepatic encephalopathy. The area under the ROC curve of FIPS was 0.744 (95% confidence interval: 0.684– 0.798). FIPS was identified as an independent risk factor for post-TIPS hepatic encephalopathy (hazard ratio: 2.23, 95% confidence interval: 1.71– 2.90, p< 0.001). Moreover, we further grouped the FIPS scores into two categories (FIPS ≤-0.97, low-risk; FIPS >-0.97, high risk) to improve its applicability. Patients with high FIPS scores had a significantly higher incidence of hepatic encephalopathy than patients with low FIPS scores (P< 0.05).Conclusion: This study showed that FIPS could be used to evaluate the risk of hepatic encephalopathy in this patient group with improved predictive performance when compared with the Child–Pugh and MELD scores.Keywords: transjugular intrahepatic portosystemic shunts, hepatic encephalopathy, Freiburg index of post-TIPS survival, model for end-stage liver diseasehttps://www.dovepress.com/prediction-of-patient-hepatic-encephalopathy-risk-with-freiburg-index--peer-reviewed-fulltext-article-IJGMtransjugular intrahepatic portosystemic shuntshepatic encephalopathyfreiburg index of post-tips survivalmodel for end-stage liver disease. |
| spellingShingle | Cai W Zheng B Lin X Wu W Chen C Prediction of Patient Hepatic Encephalopathy Risk with Freiburg Index of Post-TIPS Survival Score Following Transjugular Intrahepatic Portosystemic Shunts: A Retrospective Study International Journal of General Medicine transjugular intrahepatic portosystemic shunts hepatic encephalopathy freiburg index of post-tips survival model for end-stage liver disease. |
| title | Prediction of Patient Hepatic Encephalopathy Risk with Freiburg Index of Post-TIPS Survival Score Following Transjugular Intrahepatic Portosystemic Shunts: A Retrospective Study |
| title_full | Prediction of Patient Hepatic Encephalopathy Risk with Freiburg Index of Post-TIPS Survival Score Following Transjugular Intrahepatic Portosystemic Shunts: A Retrospective Study |
| title_fullStr | Prediction of Patient Hepatic Encephalopathy Risk with Freiburg Index of Post-TIPS Survival Score Following Transjugular Intrahepatic Portosystemic Shunts: A Retrospective Study |
| title_full_unstemmed | Prediction of Patient Hepatic Encephalopathy Risk with Freiburg Index of Post-TIPS Survival Score Following Transjugular Intrahepatic Portosystemic Shunts: A Retrospective Study |
| title_short | Prediction of Patient Hepatic Encephalopathy Risk with Freiburg Index of Post-TIPS Survival Score Following Transjugular Intrahepatic Portosystemic Shunts: A Retrospective Study |
| title_sort | prediction of patient hepatic encephalopathy risk with freiburg index of post tips survival score following transjugular intrahepatic portosystemic shunts a retrospective study |
| topic | transjugular intrahepatic portosystemic shunts hepatic encephalopathy freiburg index of post-tips survival model for end-stage liver disease. |
| url | https://www.dovepress.com/prediction-of-patient-hepatic-encephalopathy-risk-with-freiburg-index--peer-reviewed-fulltext-article-IJGM |
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