Mesenchymal Stem Cells in Sepsis: From Basic Research to Clinical Application
Abstract Sepsis is a life-threatening organ dysfunction caused by a deregulated host response to infection, and is the most common cause of death in the intensive care unit. Although the pathogenesis of sepsis has made substantial progress, the current clinical treatment of sepsis is basically sympt...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Springer
2021-06-01
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| Series: | Intensive Care Research |
| Subjects: | |
| Online Access: | https://doi.org/10.2991/icres.k.210622.001 |
| _version_ | 1797274444113117184 |
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| author | Junyi Sun Xianfei Ding Tongwen Sun |
| author_facet | Junyi Sun Xianfei Ding Tongwen Sun |
| author_sort | Junyi Sun |
| collection | DOAJ |
| description | Abstract Sepsis is a life-threatening organ dysfunction caused by a deregulated host response to infection, and is the most common cause of death in the intensive care unit. Although the pathogenesis of sepsis has made substantial progress, the current clinical treatment of sepsis is basically symptomatic treatment, including the infusion of antibiotics and catecholamine, and no effective conventional treatment has been found. The focus of research is Mesenchymal Stem Cells (MSCs). It can be a novel therapeutic tool to treat sepsis. MSCs have the characteristics of anti-inflammatory, antibacterial, anti-apoptosis, regulating immunity, and tissue and organ repair. The pre-clinical research and a few clinical phase I studies are reviewed to review the current cell therapy for sepsis. Using the characteristics of MSCs provides new ideas for the treatment of sepsis. |
| first_indexed | 2024-03-07T14:59:24Z |
| format | Article |
| id | doaj.art-63f33e579b134b3d97e5cc034c4b9ba1 |
| institution | Directory Open Access Journal |
| issn | 2666-9862 |
| language | English |
| last_indexed | 2024-03-07T14:59:24Z |
| publishDate | 2021-06-01 |
| publisher | Springer |
| record_format | Article |
| series | Intensive Care Research |
| spelling | doaj.art-63f33e579b134b3d97e5cc034c4b9ba12024-03-05T19:15:08ZengSpringerIntensive Care Research2666-98622021-06-0111-221010.2991/icres.k.210622.001Mesenchymal Stem Cells in Sepsis: From Basic Research to Clinical ApplicationJunyi Sun0Xianfei Ding1Tongwen Sun2General ICU, The First Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Critical Care Medicine, Zhengzhou Key Laboratory of Sepsis, Henan Engineering Research Center for Critical Care MedicineGeneral ICU, The First Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Critical Care Medicine, Zhengzhou Key Laboratory of Sepsis, Henan Engineering Research Center for Critical Care MedicineGeneral ICU, The First Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Critical Care Medicine, Zhengzhou Key Laboratory of Sepsis, Henan Engineering Research Center for Critical Care MedicineAbstract Sepsis is a life-threatening organ dysfunction caused by a deregulated host response to infection, and is the most common cause of death in the intensive care unit. Although the pathogenesis of sepsis has made substantial progress, the current clinical treatment of sepsis is basically symptomatic treatment, including the infusion of antibiotics and catecholamine, and no effective conventional treatment has been found. The focus of research is Mesenchymal Stem Cells (MSCs). It can be a novel therapeutic tool to treat sepsis. MSCs have the characteristics of anti-inflammatory, antibacterial, anti-apoptosis, regulating immunity, and tissue and organ repair. The pre-clinical research and a few clinical phase I studies are reviewed to review the current cell therapy for sepsis. Using the characteristics of MSCs provides new ideas for the treatment of sepsis.https://doi.org/10.2991/icres.k.210622.001Mesenchymal stem cellstherapysepsis |
| spellingShingle | Junyi Sun Xianfei Ding Tongwen Sun Mesenchymal Stem Cells in Sepsis: From Basic Research to Clinical Application Intensive Care Research Mesenchymal stem cells therapy sepsis |
| title | Mesenchymal Stem Cells in Sepsis: From Basic Research to Clinical Application |
| title_full | Mesenchymal Stem Cells in Sepsis: From Basic Research to Clinical Application |
| title_fullStr | Mesenchymal Stem Cells in Sepsis: From Basic Research to Clinical Application |
| title_full_unstemmed | Mesenchymal Stem Cells in Sepsis: From Basic Research to Clinical Application |
| title_short | Mesenchymal Stem Cells in Sepsis: From Basic Research to Clinical Application |
| title_sort | mesenchymal stem cells in sepsis from basic research to clinical application |
| topic | Mesenchymal stem cells therapy sepsis |
| url | https://doi.org/10.2991/icres.k.210622.001 |
| work_keys_str_mv | AT junyisun mesenchymalstemcellsinsepsisfrombasicresearchtoclinicalapplication AT xianfeiding mesenchymalstemcellsinsepsisfrombasicresearchtoclinicalapplication AT tongwensun mesenchymalstemcellsinsepsisfrombasicresearchtoclinicalapplication |