Current Knowledge on the Multifactorial Regulation of Corpora Lutea Lifespan: The Rabbit Model
Our research group studied the biological regulatory mechanisms of the corpora lutea (CL), paying particular attention to the pseudopregnant rabbit model, which has the advantage that the relative luteal age following ovulation is induced by the gonadotrophin-releasing hormone (GnRH). CL are tempora...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/11/2/296 |
| _version_ | 1797407833166184448 |
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| author | Massimo Zerani Angela Polisca Cristiano Boiti Margherita Maranesi |
| author_facet | Massimo Zerani Angela Polisca Cristiano Boiti Margherita Maranesi |
| author_sort | Massimo Zerani |
| collection | DOAJ |
| description | Our research group studied the biological regulatory mechanisms of the corpora lutea (CL), paying particular attention to the pseudopregnant rabbit model, which has the advantage that the relative luteal age following ovulation is induced by the gonadotrophin-releasing hormone (GnRH). CL are temporary endocrine structures that secrete progesterone, which is essential for maintaining a healthy pregnancy. It is now clear that, besides the classical regulatory mechanism exerted by prostaglandin E2 (luteotropic) and prostaglandin F2 (luteolytic), a considerable number of other effectors assist in the regulation of CL. The aim of this paper is to summarize our current knowledge of the multifactorial mechanisms regulating CL lifespan in rabbits. Given the essential role of CL in reproductive success, a deeper understanding of the regulatory mechanisms will provide us with valuable insights on various reproductive issues that hinder fertility in this and other mammalian species, allowing to overcome the challenges for new and more efficient breeding strategies. |
| first_indexed | 2024-03-09T03:47:22Z |
| format | Article |
| id | doaj.art-63f539b55b464e79a546e0639bff26ed |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T03:47:22Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-63f539b55b464e79a546e0639bff26ed2023-12-03T14:32:05ZengMDPI AGAnimals2076-26152021-01-0111229610.3390/ani11020296Current Knowledge on the Multifactorial Regulation of Corpora Lutea Lifespan: The Rabbit ModelMassimo Zerani0Angela Polisca1Cristiano Boiti2Margherita Maranesi3Dipartimento di Medicina veterinaria, Università di Perugia, via San Costanzo 4, 06126 Perugia, ItalyDipartimento di Medicina veterinaria, Università di Perugia, via San Costanzo 4, 06126 Perugia, ItalyDipartimento di Medicina veterinaria, Università di Perugia, via San Costanzo 4, 06126 Perugia, ItalyDipartimento di Medicina veterinaria, Università di Perugia, via San Costanzo 4, 06126 Perugia, ItalyOur research group studied the biological regulatory mechanisms of the corpora lutea (CL), paying particular attention to the pseudopregnant rabbit model, which has the advantage that the relative luteal age following ovulation is induced by the gonadotrophin-releasing hormone (GnRH). CL are temporary endocrine structures that secrete progesterone, which is essential for maintaining a healthy pregnancy. It is now clear that, besides the classical regulatory mechanism exerted by prostaglandin E2 (luteotropic) and prostaglandin F2 (luteolytic), a considerable number of other effectors assist in the regulation of CL. The aim of this paper is to summarize our current knowledge of the multifactorial mechanisms regulating CL lifespan in rabbits. Given the essential role of CL in reproductive success, a deeper understanding of the regulatory mechanisms will provide us with valuable insights on various reproductive issues that hinder fertility in this and other mammalian species, allowing to overcome the challenges for new and more efficient breeding strategies.https://www.mdpi.com/2076-2615/11/2/296rabbitcorpus luteumreproduction |
| spellingShingle | Massimo Zerani Angela Polisca Cristiano Boiti Margherita Maranesi Current Knowledge on the Multifactorial Regulation of Corpora Lutea Lifespan: The Rabbit Model Animals rabbit corpus luteum reproduction |
| title | Current Knowledge on the Multifactorial Regulation of Corpora Lutea Lifespan: The Rabbit Model |
| title_full | Current Knowledge on the Multifactorial Regulation of Corpora Lutea Lifespan: The Rabbit Model |
| title_fullStr | Current Knowledge on the Multifactorial Regulation of Corpora Lutea Lifespan: The Rabbit Model |
| title_full_unstemmed | Current Knowledge on the Multifactorial Regulation of Corpora Lutea Lifespan: The Rabbit Model |
| title_short | Current Knowledge on the Multifactorial Regulation of Corpora Lutea Lifespan: The Rabbit Model |
| title_sort | current knowledge on the multifactorial regulation of corpora lutea lifespan the rabbit model |
| topic | rabbit corpus luteum reproduction |
| url | https://www.mdpi.com/2076-2615/11/2/296 |
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