Noninvasive imaging biomarkers for liver fibrosis in nonalcoholic fatty liver disease: current and future
Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent worldwide and becoming a major cause of liver disease-related morbidity and mortality. The presence of liver fibrosis in patients with NAFLD is closely related to prognosis, including the development of hepatocellular carcinoma and o...
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of the Liver
2023-02-01
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| Series: | Clinical and Molecular Hepatology |
| Subjects: | |
| Online Access: | http://e-cmh.org/upload/pdf/cmh-2022-0436.pdf |
| _version_ | 1797871509956460544 |
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| author | Jung Hwan Yu Han Ah Lee Seung Up Kim |
| author_facet | Jung Hwan Yu Han Ah Lee Seung Up Kim |
| author_sort | Jung Hwan Yu |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent worldwide and becoming a major cause of liver disease-related morbidity and mortality. The presence of liver fibrosis in patients with NAFLD is closely related to prognosis, including the development of hepatocellular carcinoma and other complications of cirrhosis. Therefore, assessment of the presence of significant or advanced liver fibrosis is crucial. Although liver biopsy has been considered the “gold standard” method for evaluating the degree of liver fibrosis, it is not suitable for extensive use in all patients with NAFLD owing to its invasiveness and high cost. Therefore, noninvasive biochemical and imaging biomarkers have been developed to overcome the limitations of liver biopsy. Imaging biomarkers for the stratification of liver fibrosis have been evaluated in patients with NAFLD using different imaging techniques, such as transient elastography, shear wave elastography, and magnetic resonance elastography. Furthermore, artificial intelligence and deep learning methods are increasingly being applied to improve the diagnostic accuracy of imaging techniques and overcome the pitfalls of existing imaging biomarkers. In this review, we describe the usefulness and future prospects of noninvasive imaging biomarkers that have been studied and used to evaluate the degree of liver fibrosis in patients with NAFLD. |
| first_indexed | 2024-04-10T00:45:00Z |
| format | Article |
| id | doaj.art-63f56be295084525aa0d7e32886aaecd |
| institution | Directory Open Access Journal |
| issn | 2287-2728 2287-285X |
| language | English |
| last_indexed | 2024-04-10T00:45:00Z |
| publishDate | 2023-02-01 |
| publisher | Korean Association for the Study of the Liver |
| record_format | Article |
| series | Clinical and Molecular Hepatology |
| spelling | doaj.art-63f56be295084525aa0d7e32886aaecd2023-03-14T01:46:51ZengKorean Association for the Study of the LiverClinical and Molecular Hepatology2287-27282287-285X2023-02-0129SupplS136S14910.3350/cmh.2022.04361744Noninvasive imaging biomarkers for liver fibrosis in nonalcoholic fatty liver disease: current and futureJung Hwan Yu0Han Ah Lee1Seung Up Kim2 Department of Internal Medicine, Inha University Hospital and School of Medicine, Incheon, Korea Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea Department of Internal Medicine, Yonsei University College of Medicine, Seoul, KoreaNonalcoholic fatty liver disease (NAFLD) is increasingly prevalent worldwide and becoming a major cause of liver disease-related morbidity and mortality. The presence of liver fibrosis in patients with NAFLD is closely related to prognosis, including the development of hepatocellular carcinoma and other complications of cirrhosis. Therefore, assessment of the presence of significant or advanced liver fibrosis is crucial. Although liver biopsy has been considered the “gold standard” method for evaluating the degree of liver fibrosis, it is not suitable for extensive use in all patients with NAFLD owing to its invasiveness and high cost. Therefore, noninvasive biochemical and imaging biomarkers have been developed to overcome the limitations of liver biopsy. Imaging biomarkers for the stratification of liver fibrosis have been evaluated in patients with NAFLD using different imaging techniques, such as transient elastography, shear wave elastography, and magnetic resonance elastography. Furthermore, artificial intelligence and deep learning methods are increasingly being applied to improve the diagnostic accuracy of imaging techniques and overcome the pitfalls of existing imaging biomarkers. In this review, we describe the usefulness and future prospects of noninvasive imaging biomarkers that have been studied and used to evaluate the degree of liver fibrosis in patients with NAFLD.http://e-cmh.org/upload/pdf/cmh-2022-0436.pdfdiagnostic imagingbiomarkersliver fibrosisnonalcoholic fatty liver disease |
| spellingShingle | Jung Hwan Yu Han Ah Lee Seung Up Kim Noninvasive imaging biomarkers for liver fibrosis in nonalcoholic fatty liver disease: current and future Clinical and Molecular Hepatology diagnostic imaging biomarkers liver fibrosis nonalcoholic fatty liver disease |
| title | Noninvasive imaging biomarkers for liver fibrosis in nonalcoholic fatty liver disease: current and future |
| title_full | Noninvasive imaging biomarkers for liver fibrosis in nonalcoholic fatty liver disease: current and future |
| title_fullStr | Noninvasive imaging biomarkers for liver fibrosis in nonalcoholic fatty liver disease: current and future |
| title_full_unstemmed | Noninvasive imaging biomarkers for liver fibrosis in nonalcoholic fatty liver disease: current and future |
| title_short | Noninvasive imaging biomarkers for liver fibrosis in nonalcoholic fatty liver disease: current and future |
| title_sort | noninvasive imaging biomarkers for liver fibrosis in nonalcoholic fatty liver disease current and future |
| topic | diagnostic imaging biomarkers liver fibrosis nonalcoholic fatty liver disease |
| url | http://e-cmh.org/upload/pdf/cmh-2022-0436.pdf |
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