Deciphering Complex Interactions in Bioactive Lipid Signaling
Lipids are usually viewed as metabolic fuel and structural membrane components. Yet, in recent years, different families of lipids able to act as authentic messengers between cells and/or intracellularly have been discovered. Such lipid signals have been shown to exert their biological activity via...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/6/2622 |
| _version_ | 1797609917352247296 |
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| author | Mauro Maccarrone |
| author_facet | Mauro Maccarrone |
| author_sort | Mauro Maccarrone |
| collection | DOAJ |
| description | Lipids are usually viewed as metabolic fuel and structural membrane components. Yet, in recent years, different families of lipids able to act as authentic messengers between cells and/or intracellularly have been discovered. Such lipid signals have been shown to exert their biological activity via specific receptors that, by triggering distinct signal transduction pathways, regulate manifold pathophysiological processes in our body. Here, endogenous bioactive lipids produced from arachidonic acid (AA) and other poly-unsaturated fatty acids will be presented, in order to put into better perspective the relevance of their mutual interactions for health and disease conditions. To this end, metabolism and signal transduction pathways of classical eicosanoids, endocannabinoids and specialized pro-resolving mediators will be described, and the intersections and commonalities of their metabolic enzymes and binding receptors will be discussed. Moreover, the interactions of AA-derived signals with other bioactive lipids such as shingosine-1-phosphate and steroid hormones will be addressed. |
| first_indexed | 2024-03-11T06:07:19Z |
| format | Article |
| id | doaj.art-63f6a5a9a5ae46c3b933f0eecc9eb7b5 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T06:07:19Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-63f6a5a9a5ae46c3b933f0eecc9eb7b52023-11-17T12:52:53ZengMDPI AGMolecules1420-30492023-03-01286262210.3390/molecules28062622Deciphering Complex Interactions in Bioactive Lipid SignalingMauro Maccarrone0Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, ItalyLipids are usually viewed as metabolic fuel and structural membrane components. Yet, in recent years, different families of lipids able to act as authentic messengers between cells and/or intracellularly have been discovered. Such lipid signals have been shown to exert their biological activity via specific receptors that, by triggering distinct signal transduction pathways, regulate manifold pathophysiological processes in our body. Here, endogenous bioactive lipids produced from arachidonic acid (AA) and other poly-unsaturated fatty acids will be presented, in order to put into better perspective the relevance of their mutual interactions for health and disease conditions. To this end, metabolism and signal transduction pathways of classical eicosanoids, endocannabinoids and specialized pro-resolving mediators will be described, and the intersections and commonalities of their metabolic enzymes and binding receptors will be discussed. Moreover, the interactions of AA-derived signals with other bioactive lipids such as shingosine-1-phosphate and steroid hormones will be addressed.https://www.mdpi.com/1420-3049/28/6/2622biased signalingeicosanoidendocannabinoidmetabolismsignal transductionspecialized pro-resolving mediator |
| spellingShingle | Mauro Maccarrone Deciphering Complex Interactions in Bioactive Lipid Signaling Molecules biased signaling eicosanoid endocannabinoid metabolism signal transduction specialized pro-resolving mediator |
| title | Deciphering Complex Interactions in Bioactive Lipid Signaling |
| title_full | Deciphering Complex Interactions in Bioactive Lipid Signaling |
| title_fullStr | Deciphering Complex Interactions in Bioactive Lipid Signaling |
| title_full_unstemmed | Deciphering Complex Interactions in Bioactive Lipid Signaling |
| title_short | Deciphering Complex Interactions in Bioactive Lipid Signaling |
| title_sort | deciphering complex interactions in bioactive lipid signaling |
| topic | biased signaling eicosanoid endocannabinoid metabolism signal transduction specialized pro-resolving mediator |
| url | https://www.mdpi.com/1420-3049/28/6/2622 |
| work_keys_str_mv | AT mauromaccarrone decipheringcomplexinteractionsinbioactivelipidsignaling |